Výsledky vyhledávání - "Jean-Yves Valnot"

Synthesis, separation and structure determination of atropisomeric ketimines: precursors of new potential chiral ligands and phase-transfer catalysts

Autor: Marc Runghen, Jacques Maddaluno, Said Gmouh, Jean-Yves Valnot, Abdelaziz Retmane, Jamal Jamal Eddine, Hassan Oulyadi, Loïc Toupet

Publikováno v: Tetrahedron: Asymmetry. 19:1523-1531

Sterically crowded chiral biaryl ketimines have been prepared via nucleophilic addition onto a substituted benzonitrile or 8-cyanoquinoline and subsequent treatment of the resulting methylenimines either with methyl iodide, or with a chiral primary a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e43f974f449c24d173f6c27567c28f44
https://doi.org/10.1016/j.tetasy.2008.06.024

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Origin of the Detrimental Effect of Lithium Halides on an Enantioselective Nucleophilic Alkylation of Aldehydes

Autor: Anne Harrison-Marchand, Jacques Maddaluno, Franck Paté, Hassan Oulyadi, Marie-Claire Lasne, Catherine Fressigné, Jean-Yves Valnot, Nicolas Duguet

Publikováno v: Journal of Organic Chemistry
Journal of Organic Chemistry, American Chemical Society, 2007, 72 (18), pp.6982-6991. ⟨10.1021/jo071160x⟩

The effect of lithium halides on the enantioselectivity of the addition of methyllithium on o-tolualdehyde, in the presence of chiral lithium amides derived from chiral 3-aminopyrrolidines (3APLi), has been investigated. The enantiomeric excess of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc96054eadf2df37ada9b4b87058fdc4
https://doi.org/10.1021/jo071160x

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Second-generation synthesis of protected phosphonothiodifluoromethylene analogues of nucleoside-3′-phosphates

Autor: Jean-Yves Valnot, Arnaud Gautier, Serge R. Piettre, Irina Kalinina, Carmen Salcedo

Publikováno v: Tetrahedron. 60:4895-4900

A practical, eight-step synthesis of the key intermediate 14 in 19% overall yield from α- d -xylose is described. The preparation can be carried out on multi-gram scale and involves the use of the organomagnesium reagent 2d . The capability of deriv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8052c60b2ef32c356b75d5057c446b84
https://doi.org/10.1016/j.tet.2004.03.082

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Structure-Selectivity Relationship in Alkyllithium−Aldehyde Condensations Using 3-Aminopyrrolidine Lithium Amides as Chiral Auxiliaries

Autor: Aline Corruble, Jean-Yves Valnot, Pierre Duhamel, Jacques Maddaluno

Publikováno v: The Journal of Organic Chemistry. 63:8266-8275

A nonracemizing route to a set of chiral 3-aminopyrrolidines, based on 4-hydroxy-(l)-proline, is described. The induction potential of the lithium amides derived from these diamines has then been investigated in the asymmetric addition of alkyllithiu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::204639367b143772823b840d0d58d34d
https://doi.org/10.1021/jo9810260

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Multinuclear NMR characterisation of the complexes between chiral 3-aminopyrrolidine lithium amides and n-butyllithium

Autor: Aline Corruble, Yann Prigent, Jacques Maddaluno, Pierre Duhamel, Daniel Davoust, Jean-Yves Valnot

Publikováno v: Scopus-Elsevier

L'etude du transfert de chiralite, dans la reaction de condensation du n-butyllithium sur les aldehydes aromatiques en presence d'amidures de lithium derives d'une serie de 3-aminopyrrolidines optiquement actives, est abordee via la determination de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d7193c3591d216ad439f4e9406255fb
https://doi.org/10.1051/jcp:1998151

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Probing the Origins of Asymmetric Induction by 3-Aminopyrrolidine Lithium Amides Complexes: A 6Li/1H/13C NMR Study

Autor: Yann Prigent, Pierre Duhamel, Daniel Davoust, Aline Corruble, Jean-Yves Valnot, Jacques Maddaluno

Publikováno v: Journal of the American Chemical Society. 119:10042-10048

The structure of two chiral N,N‘-disubstituted-3-aminopyrrolidine lithium amides 3 and 4 in solution in THF-d8 has been studied at low temperatures by high-field 1H, 13C, and 6Li NMR spectroscopy. Despite their structural analogy, these two compoun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f0626db99f36ba0461cc75e7e0c968bb
https://doi.org/10.1021/ja9710464

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3-Aminopyrrolidine lithium amide in enantioselective addition of organolithium compounds onto aromatic aldehydes

Autor: Aline Corruble, Jean-Yves Valnot, Pierre Duhamel, Jacques Maddaluno

Publikováno v: Tetrahedron: Asymmetry. 8:1519-1523

New N,N′-disubstituted-3-aminopyrrolidines lithium amides have been used as chiral auxiliaries in the asymmetric condensation of n-butyllithium onto aromatic aldehydes, leading to e.e.s up to 73%.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c515351fe6eab2399d4d9015cddc7537
https://doi.org/10.1016/s0957-4166(97)00114-6

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Asymmetric Synthesis of 2-chloro- and 2-bromo-alkanoic acids by halogenation of α-D-glucofuranose-derived silyl ketene acetals

Autor: Gérard Plé, J. L. Chaumette, Pierre Duhamel, J. R. Desmurs, Jean-Yves Valnot, Lucette Duhamel, Patrick Angibaud

Publikováno v: Tetrahedron: Asymmetry. 6:1919-1932

Optically active (S)-2-bromo- and 2-chloro-alkanoic acids 6 and 7 have been obtained via the diastereoselective halogenation of chiral silyl ketene acetals 3a-f , and subsequent saponification of the resulting crude esters. Examples characterized by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0f9f755d690baecbd82b6ee2e01cd60
https://doi.org/10.1016/0957-4166(95)00251-j

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