Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jean-Yves Legendre"'
Effect of Polyoxyl 35 Castor Oil and Polysorbate 80 on the Intestinal Absorption of Digoxin in vitro
Autor:
Gilles Cornaire, Alix Cloarec, John F. Woodley, Jean-Yves Legendre, Georges Houin, Sylvie Saivin, Sylvie Decourt
Publikováno v:
Arzneimittelforschung. 50:576-579
Surfactants are classically used to improve the solubilization of lipophilic drugs such as digoxin. Polysorbate 80 and Cremophor EL (polyoxyl 35 castor oil) are such surfactants but they may also modulate the action of P-glycoprotein, an energy-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7056e5f7647d490784b2a7c2a6a7eba1
https://doi.org/10.1055/s-0031-1300252
https://doi.org/10.1055/s-0031-1300252
Publikováno v:
Journal of Liposome Research. 8:347-366
Gene delivery and expression in mammalian cells can be facilitated by a complex composed of the cyclic amphipathic peptides, gramicidin S or tyro-cidine, dioleoylphosphatidylethanolamine (Dope) and DNA. We have characterized physical features of comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2331271d1e46156ed5734d0f05682409
https://doi.org/10.3109/08982109809035539
https://doi.org/10.3109/08982109809035539
Autor:
Toon Stegmann, Jean-Yves Legendre
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1325:71-79
Complexes of DNA with cationic lipids are used to transfect eukaryotic cells. The mechanism of transfection is unknown, but it has been suggested that the complexes are taken up into the cell by endocytosis, after which fusion of the cationic lipids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d428d6960b4e6e12afffd181cf3ddb0e
https://doi.org/10.1016/s0005-2736(96)00241-6
https://doi.org/10.1016/s0005-2736(96)00241-6
Publikováno v:
Pharmaceutical Research. 14:619-624
Purpose. This study investigates the structure/activity relationship of a series of N-acyl-peptides (lipopeptides) for the transfection of mammalian cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1174dce2669df617272aded64fa85265
https://doi.org/10.1023/a:1012105128722
https://doi.org/10.1023/a:1012105128722
Autor:
Jean-Yves Legendre, Francis C. Szoka
Publikováno v:
Proceedings of the National Academy of Sciences. 90:893-897
A DNA transfection protocol has been developed that makes use of the cyclic cationic amphipathic peptide gramicidin S and dioleoyl phosphatidylethanolamine. The DNA complex is formed by mixing gramicidin S with DNA at a 1:1 charge ratio and then addi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dbad7ec7eb25b570946bba473f453a
https://doi.org/10.1073/pnas.90.3.893
https://doi.org/10.1073/pnas.90.3.893
Autor:
Jean-Yves Legendre, Robert Farinotti, Maria Poulou, Homan Kouwatli, Georges Mahuzier, Michel Tod, Joseph Chalom
Publikováno v:
Journal of Chromatography A. 594:386-391
Luminarins 1 and 2 are labelling reagents with a quinolizinocoumarin structure and an N-hydroxysuccinimide ester reactive function. They react with primary and secondary amines under relatively mild conditions (50–80°C, 20–180 min) without a cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1cbc014ec233d6a4f21aa3c4232c3d5
https://doi.org/10.1016/0021-9673(92)80353-v
https://doi.org/10.1016/0021-9673(92)80353-v
Autor:
Jean-Yves Legendre, Francis C. Szoka
Publikováno v:
Pharmaceutical Research. :1235-1242
We compare the transfection efficiency of plasmid DNA encoding either luciferase or (β-galactosidase encapsulated in pH-sensitive liposomes or non-pH-sensitive liposomes or DNA complexed with cationic liposomes composed of dioleoyloxypropyl-trimethy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a646df3ba08107ffb8fe37c34732bbe4
https://doi.org/10.1023/a:1015836829670
https://doi.org/10.1023/a:1015836829670
Autor:
Eric A. Kitas, E. J. Schlaeger, K. Christensen, Ulrich Deuschle, Arnold Trzeciak, Andreas Supersaxo, Jean-Yves Legendre
Publikováno v:
New Developments and New Applications in Animal Cell Technology ISBN: 0792350162
The aim of the presented work was to develop a cost-effective and easily scaleable transient transfection system with mammalian cells grown in serum-free suspension culture. For this purpose the cationic polyethylenimine (PEI) and the novel hybrid mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61986750fb63bfa903f8739ae476939e
https://doi.org/10.1007/0-306-46860-3_18
https://doi.org/10.1007/0-306-46860-3_18
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 19(2-3)
The aim of this study was to determine if the use of both enzyme and surfactant in the dissolution medium changes the in vitro drug release from cross-linked hard gelatin capsules containing a water-insoluble drug. Hard gelatin capsules were cross-li
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::692b7b60396a604e0554430240ee20e3
https://pubmed.ncbi.nlm.nih.gov/12791415
https://pubmed.ncbi.nlm.nih.gov/12791415
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 12(3)
Immobilized artificial membrane (IAM) chromatography coupled to physicochemical descriptors was evaluated to model the passive intestinal absorption of drugs through rat gut sacs. The chromatographic capacity factors (log k ′ IAM ) of 12 structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974f6aa94c2f0ee5231a1b8bdd8ad918
https://pubmed.ncbi.nlm.nih.gov/11113641
https://pubmed.ncbi.nlm.nih.gov/11113641