Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Jean-Yves Lapointe"'
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154589 (2016)
Na-coupled cotransporters are proteins that use the trans-membrane electrochemical gradient of Na to activate the transport of a second solute. The sodium-glucose cotransporter 1 (SGLT1) constitutes a well-studied prototype of this transport mechanis
Externí odkaz:
https://doaj.org/article/d6b097a9d119450e8fade86bc16814a3
Autor:
Adèle Salin-Cantegrel, Masoud Shekarabi, Sarah Rasheed, François M Charron, Janet Laganière, Rebecca Gaudet, Patrick A Dion, Jean-Yves Lapointe, Guy A Rouleau
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e65294 (2013)
Loss-of-function of the potassium-chloride cotransporter 3 (KCC3) causes hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC), a severe neurodegenerative disease associated with defective midline crossing of commiss
Externí odkaz:
https://doaj.org/article/012cd131a3c2445d8d1c2c41e27c7944
Publikováno v:
American Journal of Physiology-Renal Physiology. 313:F467-F474
The cotransporter SGLT2 is responsible for 90% of renal glucose reabsorption, and we recently showed that MAP17 appears to work as a required β-subunit. We report in the present study a detailed functional characterization of human SGLT2 in coexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1b7f5752054a9c3e4f400e6e149dd43
https://doi.org/10.1152/ajprenal.00628.2016
https://doi.org/10.1152/ajprenal.00628.2016
Autor:
Michael J. Coady, Abdulah El Tarazi, Pierre Bissonnette, Yoann Lussier, René Santer, Daniel G. Bichet, Jean-Yves Lapointe, Joaquim Calado, Christopher Dumayne, Louis J. Sasseville
Publikováno v:
Journal of the American Society of Nephrology. 28:85-93
The renal proximal tubule reabsorbs 90% of the filtered glucose load through the Na+-coupled glucose transporter SGLT2, and specific inhibitors of SGLT2 are now available to patients with diabetes to increase urinary glucose excretion. Using expressi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fa3ec91d746535fba9f8e574f8c0b6
https://doi.org/10.1681/asn.2015111282
https://doi.org/10.1681/asn.2015111282
Publikováno v:
American Journal of Physiology-Cell Physiology. 307:C431-C441
The sodium/ myo-inositol transporter 2 (SMIT2) is a member of the SLC5A gene family, which is believed to share the five-transmembrane segment inverted repeat of the LeuT structural family. The two-electrode voltage-clamp (TEVC) technique was used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70646173cb9fcbb826d2f8d7863fed6d
https://doi.org/10.1152/ajpcell.00054.2014
https://doi.org/10.1152/ajpcell.00054.2014
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154589 (2016)
PLoS ONE
PLoS ONE
Na-coupled cotransporters are proteins that use the trans-membrane electrochemical gradient of Na to activate the transport of a second solute. The sodium-glucose cotransporter 1 (SGLT1) constitutes a well-studied prototype of this transport mechanis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::643bd493f5cec82fa4a1537cfd1eaa74
http://europepmc.org/articles/PMC4854415?pdf=render
http://europepmc.org/articles/PMC4854415?pdf=render
Autor:
Daniella Magen, Liron Berger, Michael J. Coady, Israel Zelikovic, Sara Selig, Jean-Yves Lapointe, Daniela Militianu, Anat Ilivitzki, Martin Tieder, Karl Skorecki
Publikováno v:
New England Journal of Medicine. 362:1102-1109
We describe two siblings from a consanguineous family with autosomal recessive Fanconi's syndrome and hypophosphatemic rickets. Genetic analysis revealed a homozygous in-frame duplication of 21 bp in SLC34A1, which encodes the renal sodium-inorganic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97a7be80643af23a7621f8a5f118d91
https://doi.org/10.1056/nejmoa0905647
https://doi.org/10.1056/nejmoa0905647
Autor:
Alexandre Leduc-Nadeau, Daniel G. Bichet, Jean-Yves Lapointe, Michèle Lonergan, Anatoly Tiulpakov, Yoann Lussier, Rafael Bedoya Perez, Marie-Françoise Arthus, Cécile Guyon, Pierre Bissonnette
Publikováno v:
American Journal of Physiology-Renal Physiology. 297:F489-F498
Aquaporin-2 (AQP2) is a water channel responsible for the final water reabsorption in renal collecting ducts. Alterations in AQP2 function induce nephrogenic diabetes insipidus (NDI), a condition characterized by severe polyuria and polydipsia. Three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89839838e49ff278ef7fb52ed00c98ab
https://doi.org/10.1152/ajprenal.90589.2008
https://doi.org/10.1152/ajprenal.90589.2008
Publikováno v:
American Journal of Physiology-Cell Physiology. 295:C1464-C1472
The ion-trap technique is an experimental approach allowing measurement of changes in ionic concentrations within a restricted space (the trap) comprised of a large-diameter ion-selective electrode apposed to a voltage-clamped Xenopus laevis oocyte.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5e99cdf37d9d6a366c4923551e7b93
https://doi.org/10.1152/ajpcell.00560.2007
https://doi.org/10.1152/ajpcell.00560.2007
Publikováno v:
American Journal of Physiology-Gastrointestinal and Liver Physiology. 293:G1300-G1307
This study presents the characterization of myo-inositol (MI) uptake in rat intestine as evaluated by use of purified membrane preparations. Three secondary active MI cotransporters have been identified; two are Na+coupled (SMIT1 and SMIT2) and one i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbbac9e90c61c5b3bbf1fd069bf38a6
https://doi.org/10.1152/ajpgi.00422.2007
https://doi.org/10.1152/ajpgi.00422.2007