Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Jean-Yves Chatton"'
Publikováno v:
iScience, Vol 27, Iss 5, Pp 109679- (2024)
Summary: Epilepsy affects millions globally with a significant portion exhibiting pharmacoresistance. Abnormal neuronal activity elevates brain lactate levels, which prompted the exploration of its receptor, the hydroxycarboxylic acid receptor 1 (HCA
Externí odkaz:
https://doaj.org/article/04987323f1204ce9b6d662c231621c3f
Autor:
Abigail Strefeler, Maxime Jan, Manfredo Quadroni, Tony Teav, Nadia Rosenberg, Jean-Yves Chatton, Nicolas Guex, Hector Gallart-Ayala, Julijana Ivanisevic
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that is characterized by altered cellular metabolism in the brain. Several of these alterations have been found to be exacerbated in females, known to be dispr
Externí odkaz:
https://doaj.org/article/4d6b2b070d5e4166abf56f7f9c3b1668
Publikováno v:
Metabolites, Vol 12, Iss 5, p 465 (2022)
Lactate can protect against damage caused by acute brain injuries both in rodents and in human patients. Besides its role as a metabolic support and alleged preferred neuronal fuel in stressful situations, an additional signaling mechanism mediated b
Externí odkaz:
https://doaj.org/article/1837b382f62743a093f3ce23b6d4866d
Autor:
Joel Wellbourne-Wood, Marc Briquet, Maxime Alessandri, Francesca Binda, Maylis Touya, Jean-Yves Chatton
Publikováno v:
Biosensors, Vol 12, Iss 3, p 143 (2022)
The status of lactate has evolved from being considered a waste product of cellular metabolism to a useful metabolic substrate and, more recently, to a signaling molecule. The fluctuations of lactate levels within biological tissues, in particular in
Externí odkaz:
https://doaj.org/article/cff3d07191554d42936c90aa166cf6a7
Autor:
David Vallois, Guy Niederhäuser, Mark Ibberson, Vini Nagaraj, Lorella Marselli, Piero Marchetti, Jean-Yves Chatton, Bernard Thorens
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e103277 (2014)
Background/aimsGluco-incretin hormones increase the glucose competence of pancreatic beta-cells by incompletely characterized mechanisms.MethodsWe searched for genes that were differentially expressed in islets from control and Glp1r-/-; Gipr-/- (dKO
Externí odkaz:
https://doaj.org/article/382879c998524f93a5a8dc3fe0323595
Autor:
Theresa S Rimmele, Jean-Yves Chatton
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e109243 (2014)
Astrocytes fulfill a central role in regulating K+ and glutamate, both released by neurons into the extracellular space during activity. Glial glutamate uptake is a secondary active process that involves the influx of three Na+ ions and one proton an
Externí odkaz:
https://doaj.org/article/efa7f9eab94a4bc5b1ead724d30caa17
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71721 (2013)
Lactate is increasingly described as an energy substrate of the brain. Beside this still debated metabolic role, lactate may have other effects on brain cells. Here, we describe lactate as a neuromodulator, able to influence the activity of cortical
Externí odkaz:
https://doaj.org/article/b1189d6593ce44df9772996f8c428b16
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9 (2011)
Externí odkaz:
https://doaj.org/article/6fee3b532d934566b9d13bebc9730578
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002232 (2011)
The highly pathogenic Old World arenavirus Lassa virus (LASV) and the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) use α-dystroglycan as a cellular receptor and enter the host cell by an unusual endocytotic pathway independent of
Externí odkaz:
https://doaj.org/article/a3e28f811d984997be858a9068af851c
Autor:
Guillaume Azarias, Jean-Yves Chatton
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e28505 (2011)
The bioenergetic status of cells is tightly regulated by the activity of cytosolic enzymes and mitochondrial ATP production. To adapt their metabolism to cellular energy needs, mitochondria have been shown to exhibit changes in their ionic compositio
Externí odkaz:
https://doaj.org/article/f4793c93a93c47e784292a4a280c4158