Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Jean-Yves Le Questel"'
Autor:
Zakaria Bouchouireb, Damien Olivier-Jimenez, Titouan Jaunet-Lahary, Steeve H. Thany, Jean-Yves Le Questel
Publikováno v:
Ecotoxicology and Environmental Safety, Vol 281, Iss , Pp 116582- (2024)
Molecular docking, pivotal in predicting small-molecule ligand binding modes, struggles with accurately identifying binding conformations and affinities. This is particularly true for neonicotinoids, insecticides whose impacts on ecosystems require p
Externí odkaz:
https://doaj.org/article/3766600ed36e40198113435dde7ffd68
Autor:
Alison Cartereau, Emiliane Taillebois, Balaji Selvam, Carine Martin, Jérôme Graton, Jean-Yves Le Questel, Steeve H. Thany
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/e04a4d2d39d94534a803122635ccc96d
Autor:
Jean-Yves Le Questel
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9630 (2023)
An accurate description of the conformational behavior of drug-like molecules is often a prerequisite for a comprehensive understanding of their behavior, in particular in the targeted receptor surroundings [...]
Externí odkaz:
https://doaj.org/article/69a480da7c324c78ba2270eaf5b9e1ba
Autor:
Benjamin Jeffries, Zhong Wang, Robert I. Troup, Anaïs Goupille, Jean-Yves Le Questel, Charlene Fallan, James S. Scott, Elisabetta Chiarparin, Jérôme Graton, Bruno Linclau
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2141-2150 (2020)
A systematic comparison of lipophilicity modulations upon fluorination of isopropyl, cyclopropyl and 3-oxetanyl substituents, at a single carbon atom, is provided using directly comparable, and easily accessible model compounds. In addition, comparis
Externí odkaz:
https://doaj.org/article/5644f5bd717b453ba99d0547aa77d2b0
Autor:
Alison Cartereau, Emiliane Taillebois, Balaji Selvam, Carine Martin, Jérôme Graton, Jean-Yves Le Questel, Steeve H. Thany
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Understanding insect nicotinic acetylcholine receptor (nAChR) subtypes is of major interest because they are the main target of several insecticides. In this study, we have cloned a cockroach Pameα7 subunit that encodes a 518 amino acid protein with
Externí odkaz:
https://doaj.org/article/d5752bb75ef9486ab1947d879a841203
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9880 (2021)
The functional expression of the cockroach Pameα7 nicotinic acetylcholine receptor subunit has been previously studied, and was found to be able to form a homomeric receptor when expressed in Xenopus laevis oocytes. In this study, we found that the
Externí odkaz:
https://doaj.org/article/75a6b343bf8f4be6992465947816d41d
Publikováno v:
Molecules, Vol 26, Iss 15, p 4568 (2021)
The nature of halogen-bond interactions was scrutinized from the perspective of astatine, potentially the strongest halogen-bond donor atom. In addition to its remarkable electronic properties (e.g., its higher aromaticity compared to benzene), C6At6
Externí odkaz:
https://doaj.org/article/a212f04b259e4031b498fcdfdc3f9cc5
Publikováno v:
The Journal of Organic Chemistry. 87:7264-7273
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45412d984316b351f9f3dfb47c8ad00f
https://doi.org/10.1021/acs.joc.2c00469
https://doi.org/10.1021/acs.joc.2c00469
Autor:
Steeve H. Thany, Céline M. Bourdin, Jérôme Graton, Adèle D. Laurent, Monique Mathé-Allainmat, Jacques Lebreton, Jean-Yves le Questel
Publikováno v:
Insects, Vol 6, Iss 4, Pp 805-814 (2015)
In the present study, the effects of low (10 ng/bee) and high (100 ng/bee) doses of acetamiprid and deltamethrin insecticides on multi-trial learning and retrieval were evaluated in the honey bee Apis mellifera. After oral application, acetamiprid an
Externí odkaz:
https://doaj.org/article/d99d195928b4483194fff70b8f4b53ca
Autor:
Wieneke, Dijk, Mathilde, Di Filippo, Sander, Kooijman, Robin, van Eenige, Antoine, Rimbert, Amandine, Caillaud, Aurélie, Thedrez, Lucie, Arnaud, Amanda, Pronk, Damien, Garçon, Thibaud, Sotin, Pierre, Lindenbaum, Enrique, Ozcariz Garcia, Jean-Paul, Pais de Barros, Laurence, Duvillard, Karim, Si-Tayeb, Nuria, Amigo, Jean-Yves, Le Questel, Patrick C N, Rensen, Cédric, Le May, Philippe, Moulin, Bertrand, Cariou
Publikováno v:
Circulation. 146(10)
Atherosclerotic cardiovascular disease is the main cause of mortality worldwide and is strongly influenced by circulating low-density lipoprotein (LDL) cholesterol levels. Only a few genes causally related to plasma LDL cholesterol levels have been i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a768ba622130f16277ab131e547af7da
https://pubmed.ncbi.nlm.nih.gov/35978009
https://pubmed.ncbi.nlm.nih.gov/35978009