Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Jean-Serge Remy"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 483-492 (2018)
We report the evaluation of 18-mer 2′-O-methyl-modified ribose oligonucleotides with a full-length phosphorothioate backbone chemically conjugated at the 5′ end to the oligospermine units (Sn-: n = 5, 15, 20, 25, and 30 [number of spermine units]
Externí odkaz:
https://doaj.org/article/c3f230b50ab44ad0bb3ef0b0af083011
Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
Alkylphospholipids (APLs) have elicited great interest as antitumor agents due to their unique mode of action on cell membranes. However, their clinical applications have been limited so far by high hemolytic activity. Recently, cationic prodrugs of
Externí odkaz:
https://doaj.org/article/83257af621d245de962c99a988babe5f
Publikováno v:
International Journal of Pharmaceutics
International Journal of Pharmaceutics, Elsevier, 2019, 566, pp.141-148
International Journal of Pharmaceutics, Elsevier, 2019, 566, pp.141-148
International audience; Small interfering RNAs (siRNAs) can down-regulate the expression of a target mRNA molecule in a sequence-specific manner, making them an attractive new class of drugs with broad potential for the treatment of diverse human dis
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 483-492 (2018)
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Elsevier, 2018, 13, pp.483-492. ⟨10.1016/j.omtn.2018.09.027⟩
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Elsevier, 2018, 13, pp.483-492. ⟨10.1016/j.omtn.2018.09.027⟩
Molecular Therapy. Nucleic Acids
We report the evaluation of 18-mer 2′-O-methyl-modified ribose oligonucleotides with a full-length phosphorothioate backbone chemically conjugated at the 5′ end to the oligospermine units (Sn-: n = 5, 15, 20, 25, and 30 [number of spermine units]
Dual Gene Delivery Reagents From Antiproliferative Alkylphospholipids for Combined Antitumor Therapy
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Frontiers Media, 2020, 8, ⟨10.3389/fchem.2020.581260⟩
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry, Frontiers Media, 2020, 8, ⟨10.3389/fchem.2020.581260⟩
Frontiers in Chemistry, Vol 8 (2020)
International audience; Alkylphospholipids (APLs) have elicited great interest as antitumor agents due to their unique mode of action on cell membranes. However, their clinical applications have been limited so far by high hemolytic activity. Recentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cb991f75507595f038d1a328183ba3
https://hal.archives-ouvertes.fr/hal-02973207
https://hal.archives-ouvertes.fr/hal-02973207
Publikováno v:
Pharmaceutical Research
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2020, 37 (6), pp.106. ⟨10.1007/s11095-020-02830-y⟩
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2020, 37 (6), ⟨10.1007/s11095-020-02830-y⟩
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2020, 37 (6), pp.106. ⟨10.1007/s11095-020-02830-y⟩
Pharmaceutical Research, American Association of Pharmaceutical Scientists, 2020, 37 (6), ⟨10.1007/s11095-020-02830-y⟩
International audience; Purpose Hemolysis is a serious side effect of antitumor alkylphospholipids (APLs) that limits dose levels and is a constraint in their use in therapeutic regimen. Nine prodrugs of promising APLs (miltefosine, perifosine, and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12e35c1dca40d345992521f84905eaf6
https://hal.archives-ouvertes.fr/hal-02990890/file/Gaillard-ms.pdf
https://hal.archives-ouvertes.fr/hal-02990890/file/Gaillard-ms.pdf
Autor:
Alain Wagner, Manon Ripoll, Patrick Neuberg, Antoine Kichler, Nassera Tounsi, Jean-Serge Remy
Publikováno v:
ACS Applied Materials & Interfaces
ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2016, 8 (45), pp.30665-30670. ⟨10.1021/acsami.6b09365⟩
ACS Applied Materials & Interfaces, Washington, D.C. : American Chemical Society, 2016, 8 (45), pp.30665-30670. ⟨10.1021/acsami.6b09365⟩
International audience; A novel generation of pH-responsive photopolymerized diacetylenic amphiphile (PDA) micelles with a diameter of 10 nm was designed and optimized for the intracellular delivery of siRNAs. Dialysis and photopolymerization of the
Publikováno v:
Chemistry-A European Journal
Chemistry-A European Journal, Wiley-VCH Verlag, 2019, 25 (68), pp.15662-15679. ⟨10.1002/chem.201903976⟩
Chemistry-A European Journal, Wiley-VCH Verlag, 2019, 25 (68), pp.15662-15679. ⟨10.1002/chem.201903976⟩
International audience; Sixteen cationic prodrugs of the antitumor alkylphospholipid (APL) erufosine were rationally synthesized to provide original gene delivery reagents with improved cytotoxicity profile. The DNA complexation properties of these c
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1943
Polymerized micelles obtained by photopolymerization of diacetylenic surfactants and which are forming polydiacetylenic systems (PDAs) have recently gained interest as stabilized monodisperse systems showing potential for the delivery of hydrophobic
Publikováno v:
Molecular Pharmaceutics
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (8), pp.2718-2728. ⟨10.1021/acs.molpharmaceut.6b00309⟩
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (8), pp.2718-2728. ⟨10.1021/acs.molpharmaceut.6b00309⟩
Oligospermine-siRNA conjugates are able to induce efficient luciferase gene silencing upon carrier-free transfection. These conjugates are readily accessible by a versatile automated chemistry that we developed using a DMT-spermine phosphoramidite re