Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jean-Sebastien Hoffmann"'
Autor:
Solenne Gaillard, Virginie Charasson, Cyril Ribeyre, Kader Salifou, Marie-Jeanne Pillaire, Jean-Sebastien Hoffmann, Angelos Constantinou, Didier Trouche, Marie Vandromme
Publikováno v:
Biology Open, Vol 10, Iss 5 (2021)
KDM5A and KDM5B histone-demethylases are overexpressed in many cancers and have been involved in drug tolerance. Here, we describe that KDM5A, together with KDM5B, contribute to replication stress (RS) response and tolerance. First, they positively r
Externí odkaz:
https://doaj.org/article/4d3dcb28a57d48f0b6bec29fbffd8a28
Publikováno v:
Genomics Data, Vol 3, Iss C, Pp 90-93 (2015)
The physiological function of the human DNA polymerase θ (pol θ) is still unclear despite its in vitro translesion synthesis capacity during DNA damage repair process. However this DNA polymerase is always present along the cell cycle in the absenc
Externí odkaz:
https://doaj.org/article/165eab501aee4f33bac7e0ea2290f256
Autor:
Guillaume Labrousse, Pierre Vande Perre, Genis Parra, Marion Jaffrelot, Laura Leroy, Frederic Chibon, Frederic Escudie, Janick Selves, Jean-Sebastien Hoffmann, Rosine Guimbaud, Malik Lutzmann
Publikováno v:
NAR Cancer. 5
The exonuclease domain of DNA polymerases epsilon's catalytic subunit (POLE) removes misincorporated nucleotides, called proofreading. POLE-exonuclease mutations cause colorectal- and endometrial cancers with an extreme burden of single nucleotide su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f762d3fdfc4c84e011c3eeaa084cf5bd
https://doi.org/10.1093/narcan/zcad011
https://doi.org/10.1093/narcan/zcad011
Autor:
Mélanie K. Prodhomme, Sarah Péricart, Roxane M. Pommier, Anne-Pierre Morel, Anne-Cécile Brunac, Camille Franchet, Caroline Moyret-Lalle, Pierre Brousset, Alain Puisieux, Jean-Sébastien Hoffmann, Agnès Tissier
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Breast cancer cells frequently acquire mutations in faithful DNA repair genes, as exemplified by BRCA-deficiency. Moreover, overexpression of an inaccurate DNA repair pathway may also be at the origin of the genetic instability arising during the cou
Externí odkaz:
https://doaj.org/article/62d2634ad0974109888f7e46b74d8f22
The unusually high frequency of misincorporation by HIV-1 reverse transcriptase (HIV RT) is likely to be the major factor in the rapid accumulation of viral mutations in AIDS, especially in the env gene. To investigate the ability of HIV RT to copy t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621ec8057d347379d3b8b0d9d31506f3
https://europepmc.org/articles/PMC307744/
https://europepmc.org/articles/PMC307744/
Autor:
Julien N. Bianco, Valérie Bergoglio, Yea-Lih Lin, Marie-Jeanne Pillaire, Anne-Lyne Schmitz, Julia Gilhodes, Amelie Lusque, Julien Mazières, Magali Lacroix-Triki, Theodoros I. Roumeliotis, Jyoti Choudhary, Jérôme Moreaux, Jean-Sébastien Hoffmann, Hélène Tourrière, Philippe Pasero
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Oncogene-induced replication stress (RS) promotes cancer development. Here, the authors report that cancer cells adapt to oncogene-induced RS by overexpressing downstream components of ATR-CHK1 pathway, Claspin and Timeless, which have protective rol
Externí odkaz:
https://doaj.org/article/fdf314771754477295f673e54990011e
Autor:
Xianning Lai, Ronan Broderick, Valérie Bergoglio, Jutta Zimmer, Sophie Badie, Wojciech Niedzwiedz, Jean-Sébastien Hoffmann, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
BRCA2-deficient cells fail to complete replication in S-phase, which results in DNA bridges and chromosome mis-segregation at mitosis. Here the authors show that MUS81 helps BRCA2-deficient cells survive replication stress by activating mitotic DNA s
Externí odkaz:
https://doaj.org/article/a8a9dca4e29c43adad08bdc9e4343805
Autor:
Malik Lutzmann, Florence Bernex, Cindy da Costa de Jesus, Dana Hodroj, Caroline Marty, Isabelle Plo, William Vainchenker, Marie Tosolini, Luc Forichon, Caroline Bret, Sophie Queille, Candice Marchive, Jean-Sébastien Hoffmann, Marcel Méchali
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2851-2865.e4 (2019)
Summary: Hematopoiesis is particularly sensitive to DNA damage. Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy. It is not known why hematopoietic cells are highly vulnerable to DNA damage. Addressing this
Externí odkaz:
https://doaj.org/article/1b5c45032647429590e52fb8e732a408
Autor:
Jean-Sébastien Hoffmann
Publikováno v:
Cells, Vol 10, Iss 6, p 1464 (2021)
The major challenge of DNA replication is to provide daughter cells with intact and fully duplicated genetic material. However, various endogenous or environmental factors can slow down or stall DNA replication forks; these replication problems are k
Externí odkaz:
https://doaj.org/article/99d6e7f968d34b55a394080d850a97fc
Autor:
Laura Garcia-Exposito, Elodie Bournique, Valérie Bergoglio, Arindam Bose, Jonathan Barroso-Gonzalez, Sufang Zhang, Justin L. Roncaioli, Marietta Lee, Callen T. Wallace, Simon C. Watkins, Patricia L. Opresko, Jean-Sébastien Hoffmann, Roderick J. O’Sullivan
Publikováno v:
Cell Reports, Vol 17, Iss 7, Pp 1858-1871 (2016)
Cancer cells rely on the activation of telomerase or the alternative lengthening of telomeres (ALT) pathways for telomere maintenance and survival. ALT involves homologous recombination (HR)-dependent exchange and/or HR-associated synthesis of telome
Externí odkaz:
https://doaj.org/article/d1fefe0ced02471e9ae73019ba400bad