Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Jean-Rene Authelin"'
Publikováno v:
PDA Journal of Pharmaceutical Science and Technology. 76:461-473
Product can experience a combination of cavitation and agitation stresses as a result of dropping post-manufacture. We optimized terephthalic acid (TA) dosimetry, hydroxyphenyl fluorescein fluorimetry, and p-nitrophenol calorimetry as tools to detect
Autor:
Mostaf Nakach, P. C. Valente, Ricardo Sousa, Lionel Bardet, Jean-Rene Authelin, Marie Wacquet, Noël Midoux
Publikováno v:
Journal of Pharmaceutical Sciences. 109:2536-2543
An approximate analytical solution to Johanson's rolling theory is derived. It is shown that the solution yields a single dimensionless parameter invariant in process scale-up or equipment transfer, which relates the densification factor with process
Publikováno v:
Journal of Pharmaceutical Sciences. 109:1123-1129
Needle clogging induces several issues during the filling step of injectable drugs, which makes essential to avoiding it to ensure a favorable outcome for the process. The suck-back function, present in peristaltic pumps, is often used empirically to
Autor:
Stephanie Greco, Cathrin Bernhardt, Mostafa Nakach, Otmar Klingler, Firas Bahloul, Jean-Rene Authelin
Publikováno v:
PDA journal of pharmaceutical science and technology. 75(1)
The freezing of biologics has been widely studied from the physical chemistry point of view, for instance in terms of cryo-concentration, excipient crystallization, pH swing, potential protein denaturation, etc. In contrast, considerations on the pro
Autor:
Miguel Rodrigues, Evgenyi Shalaev, Satish K. Singh, Serguei Tchessalov, Timothy R. McCoy, Stuart Wang, Jean-Rene Authelin
Publikováno v:
Journal of pharmaceutical sciences. 109(1)
Although many biotech products are successfully stored in the frozen state, there are cases of degradation of biologicals during freeze storage. These examples are discussed in the Perspective to emphasize the fact that stability of frozen biological
Publikováno v:
Journal of pharmaceutical sciences. 109(3)
The viscosity of high-concentration protein solutions can lead to a range of challenges in drug product manufacturing and administration. Accurately modeling the viscosity of biologics solutions in response to changes in the formulation and surroundi
Jet milling is frequently used in pharmaceutical industry to achieve different objectives. It can be used as enabling technology to overcome poor water solubility linked to hydrophobic active of pharmaceutical ingredient (API) by reducing the particl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b978082fca28d7317ed18b85c636e164
Publikováno v:
International journal of pharmaceutics. 547(1-2)
Currently, the two technologies primarily used for the manufacturing of nano-crystalline suspensions using top down process (i.e. wet milling) are high pressure homogenization (HPH) and stirred bead milling (SBM). These two technologies are based upo
Publikováno v:
Journal of pharmaceutical sciences. 106(7)
Stirred media milling is the main technology for producing colloidal nanocrystalline suspensions. A number of studies have been reported on the effect of different operating parameters for lab, pilot, and industrial scales. However, typical milling t
Publikováno v:
Journal of Pharmaceutical Sciences. 103:2663-2672
Amorphous materials, although lacking the long-range translational and rotational order of crystalline and liquid crystalline materials, possess certain local (short-range) structure. This paper reviews the distribution of one particular component pr