Zobrazeno 1 - 10
of 305
pro vyhledávání: '"Jean-Pierre Raufman"'
Autor:
Kunrong Cheng, Ahmed Chahdi, Shannon M. Larabee, Mazen Tolaymat, Margaret H. Sundel, Cinthia B. Drachenberg, Min Zhan, Shien Hu, Anan H. Said, Aaron C. Shang, Guofeng Xie, Madeline Alizadeh, Natalia Sampaio Moura, Andrea C. Bafford, Richelle T. Williams, Nader N. Hanna, Jean-Pierre Raufman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract M3 muscarinic receptors (M3R) modulate β-catenin signaling and colon neoplasia. CDC42/RAC guanine nucleotide exchange factor, βPix, binds to β-catenin in colon cancer cells, augmenting β-catenin transcriptional activity. Using in silico,
Externí odkaz:
https://doaj.org/article/70b4da240da844c3a6164a3fb1096cf6
Autor:
Madeline Alizadeh, Uni Wong, Bernadette C. Siaton, Seema A. Patil, Lauren George, Jean-Pierre Raufman, William H. Scott, Erik C. von Rosenvinge, Jacques Ravel, Raymond K. Cross
Publikováno v:
Heliyon, Vol 10, Iss 4, Pp e26571- (2024)
Background: Inflammatory Bowel Disease (IBD)-associated arthritis is a frequent and potentially debilitating complication of IBD, that can affect those with or without active intestinal disease, and is often difficult to treat. The microbiome is know
Externí odkaz:
https://doaj.org/article/326a44670ac74751b5faba920544b242
Autor:
Natalia Sampaio Moura, Alyssa Schledwitz, Madeline Alizadeh, Seema A. Patil, Jean-Pierre Raufman
Publikováno v:
Frontiers in Oncology, Vol 13 (2024)
Colorectal cancer (CRC) remains a major cause of morbidity and mortality. Therapeutic approaches for advanced CRC are limited and rarely provide long-term benefit. Enzymes comprising the 24-member matrix metalloproteinase (MMP) family of zinc- and ca
Externí odkaz:
https://doaj.org/article/b489f9e43ec143ac9b728fc1484dcf44
Autor:
Natalia Sampaio Moura, Alyssa Schledwitz, Madeline Alizadeh, Asha Kodan, Lea-Pearl Njei, Jean-Pierre Raufman
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 10, p 5316 (2024)
Acetylcholine-activated receptors are divided broadly into two major structurally distinct classes: ligand-gated ion channel nicotinic and G-protein-coupled muscarinic receptors. Each class encompasses several structurally related receptor subtypes w
Externí odkaz:
https://doaj.org/article/03b44c183f09413dad95e5c95e241b31
Autor:
Margaret H. Sundel, Natalia Sampaio Moura, Kunrong Cheng, Oscar Chatain, Shien Hu, Cinthia B. Drachenberg, Guofeng Xie, Jean-Pierre Raufman
Publikováno v:
Cancers, Vol 15, Iss 19, p 4766 (2023)
M3 muscarinic receptor (M3R) activation stimulates colon cancer cell proliferation, migration, and invasion; M3R expression is augmented in colon cancer and ablating M3R expression in mice attenuates colon neoplasia. Several lines of investigation su
Externí odkaz:
https://doaj.org/article/6a8fa3a9c9ff4a4e8f179060d7418e99
Autor:
Ting-Xi Yu, Sudhakar Kalakonda, Xiangzheng Liu, Naomi Han, Hee K. Chung, Lan Xiao, Jaladanki N. Rao, Tong-Chuan He, Jean-Pierre Raufman, Jian-Ying Wang
Publikováno v:
JCI Insight, Vol 7, Iss 19 (2022)
Intestinal epithelial integrity is commonly disrupted in patients with critical disorders, but the exact underlying mechanisms are unclear. Long noncoding RNAs transcribed from ultraconserved regions (T-UCRs) control different cell functions and are
Externí odkaz:
https://doaj.org/article/32286427e5df489383dffb0553a6911b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 12, p 10249 (2023)
Despite colorectal cancer remaining a leading worldwide cause of cancer-related death, there remains a paucity of effective treatments for advanced disease. The molecular mechanisms underlying the development of colorectal cancer include altered cell
Externí odkaz:
https://doaj.org/article/6be4736e492f46c49787fa6b4ae54923
Autor:
Madeline Alizadeh, Jean-Pierre Raufman
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 10 (2022)
Bile acids modulate cell functions in health and disease, however, the mechanisms underlying their actions on neoplastic cells in the gastrointestinal (GI) tract remain largely unknown. In this issue of the JCI, Noto et al. comprehensively analyzed h
Externí odkaz:
https://doaj.org/article/3c5845902dc34aee8919ce11ef725a8d
Autor:
Madeline Alizadeh, Natalia Sampaio Moura, Alyssa Schledwitz, Seema A. Patil, Jacques Ravel, Jean-Pierre Raufman
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2458 (2023)
Studying individual data types in isolation provides only limited and incomplete answers to complex biological questions and particularly falls short in revealing sufficient mechanistic and kinetic details. In contrast, multi-omics approaches to stud
Externí odkaz:
https://doaj.org/article/f6ba84f78aa64c86bd92c524037b3ca2
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Muscarinic receptors (MRs) in the G protein-coupled receptor superfamily are recipients and mediators of parasympathetic neural transmission within the central and enteric nervous systems. MR subtypes, M1R–M5R, encoded by CHRM1-CHRM5, expressed wid
Externí odkaz:
https://doaj.org/article/10836e62b665411a9996028361ecf1a6