Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jean-Pierre Nowicki"'
Publikováno v:
Brain Research. 664:41-48
The present investigation examined the effect of eliprodil, an atypical NMDA receptor antagonist that acts at the polyamine modulatory site, on local cerebral glucose utilization using the quantitative autoradiographic 2-[14C]deoxyglucose method in t
Autor:
Xavier Vigé, Denise Duval, Hervé Poignet, Alexandra Carreau, Bernard Scatton, Jean-Pierre Nowicki
Publikováno v:
European Journal of Pharmacology. 256:241-249
The neuroprotective effects of various doses of N ω - nitro- L -arginine have been correlated with the degree of N ω - nitro- L - arginine-induced inhibition of cortical nitric oxide synthase activity measured ex vivo. Following focal cerebral isch
Publikováno v:
Brain Research. 596:320-324
The potential neuroprotective effect of seven sigma ligands has been evaluated in a mouse model of focal cerebral ischemia (induced by coagulation of the left middle cerebral artery) and compared to that of known N-methyl-D-aspartate (NMDA) antagonis
Autor:
Jean-Pierre Nowicki, Bernard Scatton
Publisher Summary The biological activity of a drug is linked to its ability to bind to specific recognition sites located on intracellular proteins or on proteins that are integrated in the lipid bilayer of cellular membranes. These proteins possess
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ebd7fd96728049a1088eadcdb6c45380
https://doi.org/10.1016/b978-0-12-374194-3.00003-2
https://doi.org/10.1016/b978-0-12-374194-3.00003-2
Autor:
Benoit Marabout, Y. Claustre, Gilles Poughon, Jacqueline Fournier, Genevieve Bourliaud, Jesus Benavides, Pascal George, Jean-Pierre Robert, Philippe Soubrie, Franck Marguet, Michael Schumacher, Jean-Pierre Nowicki, Bernard Scatton, Emmanuel Brault, Mireille Sevrin, Philippe Liere, Badia Ferzaz
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 301(3)
In the present study, we have investigated the potential neuroprotective effects of a novel peripheral benzodiazepine binding site (PBR) ligand, 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide (SSR180575), i
Publikováno v:
Journal of neuroscience research. 59(2)
Changes in gene expression within the hippocampus induced by denervation after electrolytic fimbria-fornix lesion in rat were compared to morphological and biochemical alterations. Fimbria-fornix lesion results in degeneration of hippocampal choliner
Publikováno v:
Brain research. 776(1-2)
In the present study, we have assessed the efficacy of eliprodil, a neuroprotective agent which blocks both the modulatory polyamine site of the NMDA receptor and neuronal voltage-sensitive calcium channels, alone or in combination with the thromboly
Publikováno v:
European Journal of Pharmacology. 204:339-340
Publikováno v:
Europe PubMed Central
Focal cerebral ischemia in the rat was induced by occlusion of the left middle cerebral artery. The temporal evolution of regional energy metabolism was studied over the 14 days consequent to the induction of ischemia in the frontal, cingulate, parie
Autor:
Badia, Ferzaz, Emmanuel, Brault, Genevieve, Bourliaud, Jean-Pierre, Robert, Gilles, Poughon, Yves, Claustre, Franck, Marguet, Philippe, Liere, Michael, Schumacher, Jean-Pierre, Nowicki, Jacqueline, Fournier, Benoit, Marabout, Mireille, Sevrin, Pascal, George, Philippe, Soubrie, Jesus, Benavides, Bernard, Scatton
Publikováno v:
The Journal of Pharmacology and Experimental Therapeutics; June 2002, Vol. 301 Issue: 3 p1067-78, 12p