Zobrazeno 1 - 10
of 563
pro vyhledávání: '"Jean-Pierre J. Issa"'
Autor:
Pyoung Hwa Park, Kelsey Keith, Gennaro Calendo, Jaroslav Jelinek, Jozef Madzo, Raad Z. Gharaibeh, Jayashri Ghosh, Carmen Sapienza, Christian Jobin, Jean-Pierre J. Issa
Publikováno v:
Gut Microbes, Vol 16, Iss 1 (2024)
The intestinal microbiota is an important environmental factor implicated in CRC development. Intriguingly, modulation of DNA methylation by gut microbiota has been reported in preclinical models, although the relationship between tumor-infiltrating
Externí odkaz:
https://doaj.org/article/2856375f622b4bc5bda4e07109ea89fe
Autor:
Hanghang Zhang, Chen Huang, John Gordon, Sijia Yu, George Morton, Wayne Childers, Magid Abou-Gharbia, Yi Zhang, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Clinical Epigenetics, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background Inhibition of cyclin-dependent kinase 9 (CDK9), a novel epigenetic target in cancer, can reactivate epigenetically silenced genes in cancer by dephosphorylating the SWI/SNF chromatin remodeler BRG1. Here, we characterized the anti
Externí odkaz:
https://doaj.org/article/892c78200eb14c6280a512cb5e5194fd
Autor:
Ang Sun, Pyounghwa Park, Lauren Cole, Himani Vaidya, Shinji Maegawa, Kelsey Keith, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Christian Jobin, Jean-Pierre J. Issa
Publikováno v:
Epigenetics, Vol 18, Iss 1 (2023)
DNA methylation is an epigenetic process altered in cancer and ageing. Age-related methylation drift can be used to estimate lifespan and can be influenced by extrinsic factors such as diet. Here, we report that non-pathogenic microbiota accelerate a
Externí odkaz:
https://doaj.org/article/0d76cdc134c84fa5b279afe1435cdddd
Autor:
Himani Vaidya, Hye Seon Jeong, Kelsey Keith, Shinji Maegawa, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-18 (2023)
Abstract Background Epigenetic marks are encoded by DNA methylation and accumulate errors as organisms age. This drift correlates with lifespan, but the biology of how this occurs is still unexplained. We analyze DNA methylation with age in mouse int
Externí odkaz:
https://doaj.org/article/f5d8cc73b5694855b70f542f7cf5d21c
Autor:
Jee Yeon Kim, Jaroslav Jelinek, Young Ho Lee, Dae Hyun Kim, Keunsoo Kang, Su Hyun Ryu, Hye Rin Moon, Kwangjo Cho, Seo Hee Rha, Jae Kwan Cha, Jean-Pierre J. Issa, Jei Kim
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Changes in gene-specific promoter methylation may result from aging and environmental influences. Atherosclerosis is associated with aging and environmental effects. Thus, promoter methylation profiling may be used as an epigeneti
Externí odkaz:
https://doaj.org/article/2d292c4068ce427ba560c7c3339fddd8
Autor:
Dara M. Kusic, Jessica Heil, Stefan Zajic, Andrew Brangan, Oluseun Dairo, Stacey Heil, Gerald Feigin, Sherri Kacinko, Russell J. Buono, Thomas N. Ferraro, Rachel Rafeq, Rachel Haroz, Kaitlan Baston, Elliot Bodofsky, Michael Sabia, Matthew Salzman, Alissa Resch, Jozef Madzo, Laura B. Scheinfeldt, Jean-Pierre J. Issa, Jaroslav Jelinek
Publikováno v:
PLoS ONE, Vol 18, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/af23a40b324b484bbe9591accc2c7471
Autor:
Himani Vaidya, Hye Seon Jeong, Kelsey Keith, Shinji Maegawa, Gennaro Calendo, Jozef Madzo, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/bd9a6a03ad7940e3b37dfc96cbecbf2d
Autor:
Shoghag Panjarian, Jozef Madzo, Kelsey Keith, Carolyn M. Slater, Carmen Sapienza, Jaroslav Jelinek, Jean-Pierre J. Issa
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background DNA methylation alterations have similar patterns in normal aging tissue and in cancer. In this study, we investigated breast tissue-specific age-related DNA methylation alterations and used those methylation sites to identify ind
Externí odkaz:
https://doaj.org/article/5cb2272a37a4423e82b77f220b34343d
Autor:
Xin Hu, Marcos R. Estecio, Runzhe Chen, Alexandre Reuben, Linghua Wang, Junya Fujimoto, Jian Carrot-Zhang, Nicholas McGranahan, Lisha Ying, Junya Fukuoka, Chi-Wan Chow, Hoa H. N. Pham, Myrna C. B. Godoy, Brett W. Carter, Carmen Behrens, Jianhua Zhang, Mara B. Antonoff, Boris Sepesi, Yue Lu, Harvey I. Pass, Humam Kadara, Paul Scheet, Ara A. Vaporciyan, John V. Heymach, Ignacio I. Wistuba, J. Jack Lee, P. Andrew Futreal, Dan Su, Jean-Pierre J. Issa, Jianjun Zhang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
It is known that invasive lung adenocarcinomas evolve from pre-cancerous dysplastic lesions. In this study, the authors show that evolution of pre-cancerous lesions is accompanied by DNA methylation alterations, and that global hypomethylation correl
Externí odkaz:
https://doaj.org/article/031719f1a9f8488a91a5917acd62743f
Autor:
Christopher G. Bell, Robert Lowe, Peter D. Adams, Andrea A. Baccarelli, Stephan Beck, Jordana T. Bell, Brock C. Christensen, Vadim N. Gladyshev, Bastiaan T. Heijmans, Steve Horvath, Trey Ideker, Jean-Pierre J. Issa, Karl T. Kelsey, Riccardo E. Marioni, Wolf Reik, Caroline L. Relton, Leonard C. Schalkwyk, Andrew E. Teschendorff, Wolfgang Wagner, Kang Zhang, Vardhman K. Rakyan
Publikováno v:
Genome Biology, Vol 20, Iss 1, Pp 1-24 (2019)
Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive rese
Externí odkaz:
https://doaj.org/article/28a27bd480ce4e52b0b6b60f28afc126