Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Jean-Pierre Desager"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 40:211-214
Some microplate-based direct assays with different fluorometric substrates have been developed, among which 7-benzyloxyquinoline (BOQ) has demonstrated the highest degree of selectivity for CYP3A subfamily. In our study, we firstly developed and vali
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86eff9cb654b6536a2f0b4a0f3bc10c1
https://doi.org/10.1016/j.jpba.2005.07.002
https://doi.org/10.1016/j.jpba.2005.07.002
Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection
Autor:
Lisa A Bauman, Eckart Schott, Bradley M. Kerr, Yves Horsmans, Tobias Mueller, Kevin R. Steffy, Averett Devron R, Simon P. Fletcher, Jean-Pierre Desager, Thomas Berg
Publikováno v:
Hepatology. 42:724-731
Immune-based therapy is the mainstay treatment for chronic hepatitis C virus (HCV) infection but causes multiple side effects and achieves durable viral clearance in only approximately 50% of patients. Most new investigational anti-HCV compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1acf5bcd8b0f2d29ece7a99c66b996b9
https://doi.org/10.1002/hep.20839
https://doi.org/10.1002/hep.20839
Autor:
Jean-Pierre Desager, C. Buicu, Ulysse Gaspard, Christoph Gerlinger, R. Heithecker, Jan Endrikat
Publikováno v:
Contraception. 69:271-278
In this open-label, randomized study we compared the influence of a new oral contraceptive containing 30 jig ethinylestradiol and 3 mg drospirenone (EE + DRSP = Yasmin(TM)), with a reference preparation containing 30 jig ethinylestradiol and 150 jig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a8a8b3073cec1fd64e616b5ac22a28
https://doi.org/10.1016/j.contraception.2003.11.003
https://doi.org/10.1016/j.contraception.2003.11.003
Autor:
Yves Horsmans, Peter Stärkel, Isabelle Leclercq, Michel Hérin, Christine Sempoux, C Deby, Jean-Pierre Desager
Publikováno v:
Journal of Hepatology. 39:538-546
BACKGROUND/AIMS: Pathogenesis of non-alcoholic steatohepatitis (NASH) remains poorly understood. Cytochrome P450 2E1 (CYP 2E1), cytokines, oxidative stress and activation of hepatic stellate cells seem to play a role in this process. The aim was to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c042e1a6e57db483b52443682adb632e
https://doi.org/10.1016/s0168-8278(03)00360-x
https://doi.org/10.1016/s0168-8278(03)00360-x
Publikováno v:
British Journal of Clinical Pharmacology. 56:653-657
AIMS: To investigate the distribution of cytochrome P450 2C9 (CYP2C9) and 2C19 (CYP2C19) genotype frequencies in the Beninese and Belgian Caucasian populations. METHODS: Beninese (n = 111) and Belgian (n = 121) were genotyped for CYP2C9*2, *3, *4, *5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab69922f9ebd4c6a8b1606b4940244d7
https://doi.org/10.1046/j.1365-2125.2003.01937.x
https://doi.org/10.1046/j.1365-2125.2003.01937.x
Publikováno v:
Alimentary Pharmacology & Therapeutics. 16:79-85
BACKGROUND: The inhibition of thiopurine methyltransferase activity, one of the enzymes responsible for azathioprine metabolism, by aminosalicylates has been described in an in vitro study. This could result in a higher risk of bone marrow depression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a48dd31146664680c19d849ef83bb469
https://doi.org/10.1046/j.1365-2036.2002.01156.x
https://doi.org/10.1046/j.1365-2036.2002.01156.x
Publikováno v:
Circulation. 103:113-118
Background —Hypercholesterolemia is causally associated with defects of endothelial nitric oxide (NO)–dependent vasodilation. Increased uptake of cholesterol by endothelial cells (ECs) upregulates the abundance of the structural protein caveolin-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::302a4c9450c14f26f9725c8e3808b43a
https://doi.org/10.1161/01.cir.103.1.113
https://doi.org/10.1161/01.cir.103.1.113
Publikováno v:
Journal of Laboratory and Clinical Medicine. 135:256-262
Azathioprine (AZA) is characterized by high interindividual differences in bioavailability and metabolization. The aim of the present study was to analyze, in patients treated with AZA for various immune system disorders, whether the variation in red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5debe01af56fd0c338b14c354b3c5dc
https://doi.org/10.1067/mlc.2000.105215
https://doi.org/10.1067/mlc.2000.105215
Publikováno v:
European Journal of Internal Medicine. 11:33-38
Background: Atorvastatin provokes a strong reduction in plasma total cholesterol (TC) and LDL-cholesterol (LDL-C), an effect attributed to the increase in the receptor-mediated catabolism of LDL and well-demonstrated for statins. In addition, atorvas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be866c9723c2b5c313ea59582de9894a
https://doi.org/10.1016/s0953-6205(99)00065-5
https://doi.org/10.1016/s0953-6205(99)00065-5
Publikováno v:
Journal of Chromatography A. 828:291-296
We have developed a HPLC method which allows the determination of chlorzoxazone and its hydroxy metabolite in rat liver microsomes and in human plasma. We found that dehalogenated chlorzoxazone or 2-benzoxazolinone was a convenient and stable interna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e85aa6f020895428e32efe86f5f8339
https://doi.org/10.1016/s0021-9673(98)00588-3
https://doi.org/10.1016/s0021-9673(98)00588-3