Synthesis and in Vitro Cytotoxic Evaluation of New Derivatives of Pyrido[1,2-a]benzimidazolic Ring System: The Pyrido[1',2':1,2]imidazo[4,5-h]quinazolines

Autor: Jean-Michel Chezal, Olivier Chavignon, Yves Blache, Jean-Claude Teulade, Jean-Pierre Chapat, Marianne Dupuy, Frédéric Pinguet

Publikováno v: Chemical and Pharmaceutical Bulletin
Chemical and Pharmaceutical Bulletin, Pharmaceutical Society of Japan, 2001, 49, pp.1061-1065. ⟨10.1248/cpb.49.1061⟩

International audience; Access to the original series of pyrido[1',2':1,2]imidazo[4,5-h]quinazoline was developed from a 1,3-dicarbonyl unit with some “N-C-N” bisnucleophilic reagents and the derivatives obtained were evaluated for in vitro cytot

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c5e51461ac0aea7fa3511cf468fac1
https://doi.org/10.1248/cpb.49.1061

Synthesis and antiviral activity of imidazo[1,2-a]pyridines

Autor: Lhassani M, Jean-Pierre Chapat, Jan Balzarini, R. Snoeck, Jean-Claude Teulade, Alain Gueiffier, Olivier Chavignon, Graciela Andrei, Erik De Clercq, Jean-Michel Chezal

Publikováno v: European Journal of Medicinal Chemistry. 34:271-274

Imidazo[1,2- a ]pyridines bearing a 3-(dithiolan-, dioxolan- or oxathiolan-2-yl) substituent were synthesized from the corresponding aldehydes. The dithiolanyl derivative 6a proved active against cytomegalovirus at an inhibitory concentration (IC 50

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c766863036f7afdfc68ca833703a23f3
https://doi.org/10.1016/s0223-5234(99)80061-0

Regioselective Synthesis of Pyrazolo[4,5-g]pyrido[1,2-a]benzimidazoles: Cytotoxic Derivatives of Pyrido[1,2-a]benzimidazolic Ring System

Autor: Olivier Chavignon, Jean-Claude Teulade, Marianne Dupuy, Jean-Pierre Chapat, Yves Blache, Frederic Pingiet

Publikováno v: Chemical and Pharmaceutical Bulletin. 46:1820-1823

N-1 and N-2 substituted pyrazolo[4, 5-g]pyrido[1, 2-a]benzimidazoles were prepared regioselectively, and cytotoxicities evaluated in vitro against K562 and HL60 cells. All compounds displayed weaker activity than doxorubicin against sensitive lines,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc807a66b9385b7ebe074b1de13dcc0
https://doi.org/10.1248/cpb.46.1820

Interaction and translocation of cysteamine (mercaptoethylamine) with model membranes: a 15N-NMR and 1H-NMR study

Autor: François Berleur, G. Subra, Pierre-Antoine Bonnet, Jean-Pierre Chapat, J.-P. Fernandez, Catherine Lagoueyte, Marc Fatome, Vincent Roman, Florence Fauvelle, Jean-Claude Debouzy

Publikováno v: European Journal of Pharmaceutics and Biopharmaceutics. 43:73-81

We investigated by 15 N-NMR (nuclear magnetic resonance) spectroscopy the interactions of 15 N-labeled cysteamine ([ 15 N]mercaptoethylamine (MEA)), a radioprotecting aminothiol, with model membranes of egg yolk phosphatidylcholine (EPC) and phosphat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e34bba54180b98d50e663ffa62f3ec8
https://doi.org/10.1016/s0939-6411(96)00012-4

Synthesis and reactivity of pyrrolo[1,2-α]quinoxalines. Crystal structure and AM1 calculation

Autor: H. Viols, G. Dauphin, Olivier Chavignon, A. Elhakmaoui, A. Carpy, Jean-Claude Teulade, Yves Blache, Jean-Pierre Chapat, Gérard Grassy, A. Gueiffier

Publikováno v: Journal of Heterocyclic Chemistry. 32:1317-1324

2-Methylquinoxaline reacts with ethyl bromopyruvate giving 2-substituted pyrrolo[1,2-α]quinoxalines. The yield of the condensation depends on the functionalization of starting materials, and optimization is obtained with 2-dimethylamino-3-methylquin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::775075ee4c9f4348897c3b7246da1e92
https://doi.org/10.1002/jhet.5570320437