Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Jean-Pierre Benitah"'
Autor:
Marianne Mazevet, Anissa Belhadef, Maxance Ribeiro, Delphine Dayde, Anna Llach, Marion Laudette, Tiphaine Belleville, Philippe Mateo, Mélanie Gressette, Florence Lefebvre, Ju Chen, Christilla Bachelot-Loza, Catherine Rucker-Martin, Frank Lezoualch, Bertrand Crozatier, Jean-Pierre Benitah, Marie-Catherine Vozenin, Rodolphe Fischmeister, Ana-Maria Gomez, Christophe Lemaire, Eric Morel
Publikováno v:
eLife, Vol 12 (2023)
Anthracyclines, such as doxorubicin (Dox), are widely used chemotherapeutic agents for the treatment of solid tumors and hematologic malignancies. However, they frequently induce cardiotoxicity leading to dilated cardiomyopathy and heart failure. Thi
Externí odkaz:
https://doaj.org/article/cdffeb33bb6c47cd87e41bc7a93230d4
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 18 (2022)
Background Human cardiac biopsies are widely used in clinical and fundamental research to decipher molecular events that characterize cardiac physiological and pathophysiological states. One of the main approaches relies on the analysis of semiquanti
Externí odkaz:
https://doaj.org/article/232f72c3552141309cf266f6c8caf081
Autor:
Rogelio Salazar-Enciso, Agustín Guerrero-Hernández, Ana M. Gómez, Jean-Pierre Benitah, Angélica Rueda
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
In mesenteric arteries (MAs), aldosterone (ALDO) binds to the endogenous mineralocorticoid receptor (MR) and increases the expression of the voltage-gated L-type Cav1.2 channel, an essential ion channel for vascular contraction, sarcoplasmic reticulu
Externí odkaz:
https://doaj.org/article/653addf7fc8e4380b8526cd6db8e7914
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ handling contributes to the diminished contraction and relaxat
Externí odkaz:
https://doaj.org/article/f1f178c961e149f39524c8e8045de50d
Autor:
Jessica Sabourin, Antoine Beauvais, Rui Luo, David Montani, Jean-Pierre Benitah, Bastien Masson, Fabrice Antigny
Publikováno v:
Cells, Vol 11, Iss 20, p 3282 (2022)
Right ventricular failure (RVF) is the most important prognostic factor for morbidity and mortality in pulmonary arterial hypertension (PAH) or pulmonary hypertension (PH) caused by left heart diseases. However, right ventricle (RV) remodeling is und
Externí odkaz:
https://doaj.org/article/e899352baef14debaa355a79f7dcd4c7
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
The archetypal store-operated Ca2+ channels (SOCs), Orai1, which are stimulated by the endo/sarcoplasmic reticulum (ER/SR) Ca2+ sensor stromal interaction molecule 1 (STIM1) upon Ca2+ store depletion is traditionally viewed as instrumental for the fu
Externí odkaz:
https://doaj.org/article/6bcbdac852c94f8ca2b463b5afb2796d
Autor:
Blanca Morales Rodriguez, Alejandro Domínguez-Rodríguez, Jean-Pierre Benitah, Florence Lefebvre, Thibaut Marais, Nathalie Mougenot, Philippe Beauverger, Gisèle Bonne, Véronique Briand, Ana-María Gómez, Antoine Muchir
Publikováno v:
Biochemistry and Biophysics Reports, Vol 22, Iss , Pp - (2020)
Cardiomyopathy caused by A-type lamins gene (LMNA) mutations (LMNA cardiomyopathy) is associated with dysfunction of the heart, often leading to heart failure. LMNA cardiomyopathy is highly penetrant with bad prognosis with no specific therapy availa
Externí odkaz:
https://doaj.org/article/76c8d36fe547439f94de9406063fe6f0
Autor:
Fiona Bartoli, Soraya Moradi Bachiller, Fabrice Antigny, Kaveen Bedouet, Pascale Gerbaud, Jessica Sabourin, Jean-Pierre Benitah
Publikováno v:
Cells, Vol 9, Iss 1, p 47 (2019)
Whereas cardiac TRPC (transient receptor potential canonical) channels and the associated store-operated Ca2+ entry (SOCE) are abnormally elevated during cardiac hypertrophy and heart failure, the mechanism of this upregulation is not fully elucidate
Externí odkaz:
https://doaj.org/article/c447f6aca1034dadbefc4bc835966cdc
Autor:
Alejandro Domínguez-Rodríguez, Isabel Mayoral-Gonzalez, Javier Avila-Medina, Eva S. de Rojas-de Pedro, Eva Calderón-Sánchez, Ignacio Díaz, Abdelkrim Hmadcha, Antonio Castellano, Juan A. Rosado, Jean-Pierre Benitah, Ana M. Gomez, Antonio Ordoñez, Tarik Smani
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Aims: Urocortin-2 (Ucn-2) is a potent cardioprotector against Ischemia and Reperfusion (I/R) injuries. However, little is known about its role in the regulation of intracellular Ca2+ concentration ([Ca2+]i) under I/R. Here, we examined whether the ad
Externí odkaz:
https://doaj.org/article/0738ea49526d4ca2b7d355bafcb4903f
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53321 (2013)
Diabetes is a major risk factor for stroke. However, the molecular mechanisms involved in cerebral artery dysfunction found in the diabetic patients are not completely elucidated. In cerebral artery smooth muscle cells (CASMCs), spontaneous and local
Externí odkaz:
https://doaj.org/article/182f39b2a88943ff81f6dac4d5797a7d