Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Jean-Pierre Begue"'
La chimie du fluor est devenue un secteur important de la chimie médicinale. Depuis la découverte du fluorouracile, des fluorocorticoïdes et des fluoroquinolones, ce jeune domaine a connu de rapides et d'importants progrès durant ces quinze derni
Publikováno v:
Tetrahedron Letters. 44:6309-6312
1,2,4,5-Tetraoxanes, potent antimalarial drugs, were selectively synthesized in fluorous alcohols (2,2,2-trifluoroethanol–TFE and 1,1,1,3,3,3-hexafluoro-2-propanol–HFIP). A use of these solvents enabled for the first time a one-pot synthesis of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f53bd4b23913959dad8fdc333d0e05c6
https://doi.org/10.1016/s0040-4039(03)01472-2
https://doi.org/10.1016/s0040-4039(03)01472-2
Autor:
Michele Ourevitch, Patrick Rollin, Thi Thanh Nga Truong, Danièle Bonnet-Delpon, David Gueyrard, Jean-Pierre Begue
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3ce21141788c1d4bcd492ac1eefa5fc0
https://doi.org/10.1002/chin.199952206
https://doi.org/10.1002/chin.199952206
Publisher Summary This chapter focuses on the recent advances in the fluorinated analogues of natural products developed as pharmaceuticals. These mainly concern fluorine-substituted nucleosides, alkaloids, macrolides, steroids, amino acids, and pros
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::433e61ee315c2c0ecaf9f3497f778a9a
https://doi.org/10.1016/b978-0-444-53086-8.00013-8
https://doi.org/10.1016/b978-0-444-53086-8.00013-8
Publikováno v:
ChemInform. 36
In order to evaluate more deeply the nature of the activation of oxirane ring opening reactions by HFIP, ring opening of both CF 3 -epoxy ethers 1a (R = Ph) and 1b (R = CH 2 CH 2 Ph) with HFIP alone, and with hard (MeOH) or soft (PhSH) nucleophiles i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be686420bba93de113b5182f175907dd
https://doi.org/10.1002/chin.200540049
https://doi.org/10.1002/chin.200540049
Autor:
Danièle Bonnet-Delpon, Jean-Pierre Begue, Fatima Chorki, Bruno Pradines, Kylie Anne McIntosh, Michèle Ourévitch, Fabienne Grellepois, William N. Charman, Benoit Crousse, Sébastien Charneau, Philipe Grellier
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2004, 47 (6), pp.1423-1433. ⟨10.1021/jm030947m⟩
Journal of Medicinal Chemistry, American Chemical Society, 2004, 47 (6), pp.1423-1433. ⟨10.1021/jm030947m⟩
New fluoroartemisinin derivatives containing polar or water-soluble functionalities at C-16 (11a-j, 12a-g) were synthesized using the key intermediate 16-bromo-10-trifluoromethyl anhydrodihydroartemisinin 10. The substitution reaction from 10 was mor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ae2499cf06f71805cfd03da5352d66
https://pubmed.ncbi.nlm.nih.gov/14998331
https://pubmed.ncbi.nlm.nih.gov/14998331
Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-
Autor:
Vadim A. Soloshonok, Koichi Mikami, Takashi Yamazaki, John T. Welch, John F. Honek, Yoshimitsu Itoh, Samir Z. Zard, Manfred Schlosser, Qian Wang, Fabrice Cottet, Santos Fustero, Juan F. Sanz-Cervera, Carlos del Pozo, José Luis Aceña, Toshio Fuchigami, Toshiki Tajima, Anilkumar Raghavanpillai, Donald J. Burton, Viacheslav A. Petrov, Kazumasa Funabiki, Masaki Matsui, Junji Ichikawa, T. Ono, H. Hayakawa, N. Yasuda, H. Uekusa, Y. Ohashi, Takayuki Tonoi, Wei Zhang, Peer Kirsch, Gerd-Volker Röschenthaler, Yutaka Nakamura, Seiji Takeuchi, Nicola L. Pohl, Mounir El Bakkari, Jean-Marc Vincent, Iwao Ojima, Larissa V. Kuznetsova, Liang Sun, Feng-Ling Qing, Xiao-Long Qiu, Christopher A. Hargreaves, Graham Sandford, Benjamin G. Davis, Danièle Bonnet-Delpon, Jean-Pierre Bégué, Benoit Crousse, Fabienne Grellepois, Constance Chollet, Fatima Chorki, Guillaume Magueur, Michèle Ourévitch, Nguyen Thi Ngoc Tam, Philippe Grellier, Nguyen Van Hung, Truong Van Nhu, Doan Hanh Nhan, Nguyen Thi Minh Thu, Toshiyuki Itoh, Kunisuke Izawa, Takayoshi Torii, Tomoyuki Onishi, Tok
Publikováno v:
ChemInform. 21
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1123bddfe842637dd9f929f0dacc059
https://doi.org/10.1002/chin.199008109
https://doi.org/10.1002/chin.199008109