Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Jean-Pierre A Kocher"'
Autor:
Katharina E. Meijboom, Abbas Abdallah, Nicholas P. Fordham, Hiroko Nagase, Tomás Rodriguez, Carolyn Kraus, Tania F. Gendron, Gopinath Krishnan, Rustam Esanov, Nadja S. Andrade, Matthew J. Rybin, Melina Ramic, Zachary D. Stephens, Alireza Edraki, Meghan T. Blackwood, Aydan Kahriman, Nils Henninger, Jean-Pierre A. Kocher, Michael Benatar, Michael H. Brodsky, Leonard Petrucelli, Fen-Biao Gao, Erik J. Sontheimer, Robert H. Brown, Zane Zeier, Christian Mueller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
A hexanucleotide repeat expansion in C9ORF72 is the most common genetic cause of ALS and FTD. Here, the authors demonstrate CRISPR/Cas9 excision of the expansion results in a rescue of disease mechanisms in vivo and in vitro.
Externí odkaz:
https://doaj.org/article/3c12d94acb99423da250fefe20d4cde2
Autor:
Clara T. Nicolas, Robert A. Kaiser, Raymond D. Hickey, Kari L. Allen, Zeji Du, Caitlin J. VanLith, Rebekah M. Guthman, Bruce Amiot, Lukkana Suksanpaisan, Bing Han, Maria Giovanna Francipane, Amin Cheikhi, Huailei Jiang, Aditya Bansal, Mukesh K. Pandey, Ishan Garg, Val Lowe, Aditya Bhagwate, Daniel O’Brien, Jean-Pierre A. Kocher, Timothy R. DeGrado, Scott L. Nyberg, Eric Lagasse, Joseph B. Lillegard
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 738-750 (2020)
The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-
Externí odkaz:
https://doaj.org/article/8ffcb39c8aed4257acfa76228d16a408
Autor:
Zachary Stephens, Dragana Milosevic, Benjamin Kipp, Stefan Grebe, Ravishankar K. Iyer, Jean-Pierre A. Kocher
Publikováno v:
Frontiers in Genetics, Vol 12 (2021)
Long read sequencing technologies have the potential to accurately detect and phase variation in genomic regions that are difficult to fully characterize with conventional short read methods. These difficult to sequence regions include several clinic
Externí odkaz:
https://doaj.org/article/b11181a9f8864e89816d3eb364e98c24
A data science approach for the classification of low-grade and high-grade ovarian serous carcinomas
Autor:
Sangdi Lin, Chen Wang, Shabnam Zarei, Debra A. Bell, Sarah E. Kerr, George C. Runger, Jean-Pierre A. Kocher
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background Copy Number Alternations (CNAs) is defined as somatic gain or loss of DNA regions. The profiles of CNAs may provide a fingerprint specific to a tumor type or tumor grade. Low-coverage sequencing for reporting CNAs has recently gai
Externí odkaz:
https://doaj.org/article/4c619bcd7604480085a80b535872b3f5
Publikováno v:
BMC Medical Genomics, Vol 11, Iss S3, Pp 53-62 (2018)
Abstract Background RNA-seq is the most commonly used sequencing application. Not only does it measure gene expression but it is also an excellent media to detect important structural variants such as single nucleotide variants (SNVs), insertion/dele
Externí odkaz:
https://doaj.org/article/3eb71a09ffab4b49840fb45923001f43
Autor:
Saurabh Baheti, Xiaojia Tang, Daniel R. O’Brien, Nicholas Chia, Lewis R. Roberts, Heidi Nelson, Judy C. Boughey, Liewei Wang, Matthew P. Goetz, Jean-Pierre A. Kocher, Krishna R. Kalari
Publikováno v:
BMC Bioinformatics, Vol 19, Iss 1, Pp 1-11 (2018)
Abstract Background Transfer of genetic material from microbes or viruses into the host genome is known as horizontal gene transfer (HGT). The integration of viruses into the human genome is associated with multiple cancers, and these can now be dete
Externí odkaz:
https://doaj.org/article/dda4ddc601e146fea835753436dec370
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-16 (2018)
Abstract Background The right drug to the right patient at the right time is one of the ideals of Individualized Medicine (IM) and remains one of the most compelling promises of the post-genomic age. The addition of genomic information is expected to
Externí odkaz:
https://doaj.org/article/140dfd03d0334d79932361dbbb6b0828
Publikováno v:
BMC Bioinformatics, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background The sequence logo has been widely used to represent DNA or RNA motifs for more than three decades. Despite its intelligibility and intuitiveness, the traditional sequence logo is unable to display the intra-motif dependencies and
Externí odkaz:
https://doaj.org/article/8033d5b9c8fb48e3b477e55e36cb519f
Autor:
Liguo Wang, Han Liang, Jean-Pierre A. Kocher, Jeanette Eckel-Passow, Hon Sing Leong, Haojie Huang, Tao Ma, Ying Li, Haidong Dong, Zhenqing Ye
Purpose: Homozygous deletions play important roles in carcinogenesis. The genome-wide screening for homozygously deleted genes in many different cancer types with a large number of patient specimens representing the tumor heterogeneity has not been d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14e09231720d176b836d6b63003980f4
https://doi.org/10.1158/1078-0432.c.6526010
https://doi.org/10.1158/1078-0432.c.6526010
Autor:
Roman Thaler, Amel Dudakovic, Daniel J. Berry, Robert C. Cohen, Janet M. Denbeigh, Jean-Pierre A. Kocher, Eric A. Lewallen, David G. Lewallen, Asha Nair, Andre J. van Wijnen, Matthew P. Abdel, Wei Xu, William H. Trousdale, Jie J. Yao
Publikováno v:
Tissue Eng Part A
Metal orthopedic implants are largely biocompatible and generally achieve long-term structural fixation. However, some orthopedic implants may loosen over time even in the absence of infection. In vivo fixation failure is multifactorial, but the fund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c817336200a96f3dd4f8ba9a17d79ad
https://doi.org/10.1089/ten.tea.2020.0369
https://doi.org/10.1089/ten.tea.2020.0369