Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Jean-Philippe Nougayrède"'
Autor:
Nadine Rehm, Alexander Wallenstein, Marla Keizers, Stefan Homburg, Giuseppe Magistro, Camille V. Chagneau, Hanna Klimek, Olga Revelles, Emmanuelle Helloin, Johannes Putze, Jean-Philippe Nougayrède, Sören Schubert, Eric Oswald, Ulrich Dobrindt
Publikováno v:
mBio, Vol 13, Iss 1 (2022)
ABSTRACT Bacteria have to process several levels of gene regulation and coordination of interconnected regulatory networks to ensure the most adequate cellular response to specific growth conditions. Especially, expression of complex and costly fitne
Externí odkaz:
https://doaj.org/article/3ee19cab594d48eaa38a372aacf65fcb
Autor:
Jean-Philippe Nougayrède, Eric Oswald
Publikováno v:
mSphere, Vol 6, Iss 6 (2021)
Externí odkaz:
https://doaj.org/article/eb839c3e095449f89b1b0ad7e7033f58
Autor:
Jean-Philippe Nougayrède, Camille V. Chagneau, Jean-Paul Motta, Nadège Bossuet-Greif, Marcy Belloy, Frédéric Taieb, Jean-Jacques Gratadoux, Muriel Thomas, Philippe Langella, Eric Oswald
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked to causative mutations found in human colorectal c
Externí odkaz:
https://doaj.org/article/816552cb3c9c46a58c2d718922be086d
Autor:
Camille V Chagneau, Clémence Massip, Nadège Bossuet-Greif, Christophe Fremez, Jean-Paul Motta, Ayaka Shima, Céline Besson, Pauline Le Faouder, Nicolas Cénac, Marie-Paule Roth, Hélène Coppin, Maxime Fontanié, Patricia Martin, Jean-Philippe Nougayrède, Eric Oswald
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009310 (2021)
Urinary tract infections (UTIs) are among the most common outpatient infections, with a lifetime incidence of around 60% in women. We analysed urine samples from 223 patients with community-acquired UTIs and report the presence of the cleavage produc
Externí odkaz:
https://doaj.org/article/89b242f36991425a8d871d48eba73d41
Autor:
Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu
Publikováno v:
mSphere, Vol 5, Iss 6 (2020)
ABSTRACT Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the ke
Externí odkaz:
https://doaj.org/article/a41f1f2131b848ea963a2694822a22c8
Autor:
Alexander Wallenstein, Nadine Rehm, Marina Brinkmann, Martina Selle, Nadège Bossuet-Greif, Daniel Sauer, Boyke Bunk, Cathrin Spröer, Haleluya Tesfaye Wami, Stefan Homburg, Rudolf von Bünau, Simone König, Jean-Philippe Nougayrède, Jörg Overmann, Eric Oswald, Rolf Müller, Ulrich Dobrindt
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
Externí odkaz:
https://doaj.org/article/29cf86c4966348178bc697925149df8a
Autor:
Alexander Wallenstein, Nadine Rehm, Marina Brinkmann, Martina Selle, Nadège Bossuet-Greif, Daniel Sauer, Boyke Bunk, Cathrin Spröer, Haleluya Tesfaye Wami, Stefan Homburg, Rudolf von Bünau, Simone König, Jean-Philippe Nougayrède, Jörg Overmann, Eric Oswald, Rolf Müller, Ulrich Dobrindt
Publikováno v:
mSphere, Vol 5, Iss 4 (2020)
ABSTRACT Colibactin is a nonribosomal peptide/polyketide hybrid natural product expressed by different members of the Enterobacteriaceae which can be correlated with induction of DNA double-strand breaks and interference with cell cycle progression i
Externí odkaz:
https://doaj.org/article/bdbc7c0df600468ebd30c1cf30b0a135
Publikováno v:
Toxins, Vol 13, Iss 12, p 897 (2021)
Colibactin is a genotoxin produced primarily by Escherichia coli harboring the genomic pks island (pks+ E. coli). Pks+ E. coli cause host cell DNA damage, leading to chromosomal instability and gene mutations. The signature of colibactin-induced muta
Externí odkaz:
https://doaj.org/article/14e06752ec5d43159a01f20b072ca2cb
Autor:
Camille V. Chagneau, Christophe Garcie, Nadège Bossuet-Greif, Sophie Tronnet, Alexander O. Brachmann, Jörn Piel, Jean-Philippe Nougayrède, Patricia Martin, Eric Oswald
Publikováno v:
mSphere, Vol 4, Iss 5 (2019)
ABSTRACT Colibactin is a polyketide/nonribosomal peptide produced by Escherichia coli strains that harbor the pks island. This toxin induces DNA double-strand breaks and DNA interstrand cross-links in infected eukaryotic cells. Colibactin-producing s
Externí odkaz:
https://doaj.org/article/f385369a64724228830f1876acd7b499
Autor:
Clémence Massip, Priscilla Branchu, Nadège Bossuet-Greif, Camille V Chagneau, Déborah Gaillard, Patricia Martin, Michèle Boury, Thomas Sécher, Damien Dubois, Jean-Philippe Nougayrède, Eric Oswald
Publikováno v:
PLoS Pathogens, Vol 15, Iss 9, p e1008029 (2019)
Although Escherichia coli Nissle 1917 (EcN) has been used therapeutically for over a century, the determinants of its probiotic properties remain elusive. EcN produces two siderophore-microcins (Mcc) responsible for an antagonistic activity against o
Externí odkaz:
https://doaj.org/article/222c92eec38b4549939942a81f88c049