Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Jean-Philippe Lambert"'
Autor:
Yi Zhang, Guojia Xie, Ji-Eun Lee, Mohamad Zandian, Deepthi Sudarshan, Benjamin Estavoyer, Caroline Benz, Tiina Viita, Golareh Asgaritarghi, Catherine Lachance, Clémence Messmer, Leandro Simonetti, Vikrant Kumar Sinha, Jean-Philippe Lambert, Yu-Wen Chen, Shu-Ping Wang, Ylva Ivarsson, El Bachir Affar, Jacques Côté, Kai Ge, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The human methyltransferase and transcriptional coactivator MLL4 and its paralog MLL3 are frequently mutated in cancer. MLL4 and MLL3 monomethylate histone H3K4 and contain a set of uncharacterized PHD fingers. Here, we report a novel functi
Externí odkaz:
https://doaj.org/article/638cdaae4793463e86fdbad0e7036a1b
Autor:
Kevin Gonthier, Cindy Weidmann, Line Berthiaume, Cynthia Jobin, Aurélie Lacouture, Camille Lafront, Mario Harvey, Bertrand Neveu, Jérémy Loehr, Alain Bergeron, Yves Fradet, Louis Lacombe, Julie Riopel, Éva Latulippe, Chantal Atallah, Michael Shum, Jean‐Philippe Lambert, Frédéric Pouliot, Martin Pelletier, Étienne Audet‐Walsh
Publikováno v:
Molecular Oncology, Vol 17, Iss 10, Pp 2109-2125 (2023)
The androgen receptor (AR) is an established orchestrator of cell metabolism in prostate cancer (PCa), notably by inducing an oxidative mitochondrial program. Intriguingly, AR regulates cytoplasmic isocitrate dehydrogenase 1 (IDH1), but not its mitoc
Externí odkaz:
https://doaj.org/article/b60b3bf0f71f4ae9996565ed221a4aac
Autor:
Pakavarin Louphrasitthiphol, Alessia Loffreda, Vivian Pogenberg, Sarah Picaud, Alexander Schepsky, Hans Friedrichsen, Zhiqiang Zeng, Anahita Lashgari, Benjamin Thomas, E. Elizabeth Patton, Matthias Wilmanns, Panagis Filippakopoulos, Jean-Philippe Lambert, Eiríkur Steingrímsson, Davide Mazza, Colin R. Goding
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The ability of transcription factors to discriminate between different classes of binding sites associated with specific biological functions underpins effective gene regulation in development and homeostasis. How this is achieved is poorly
Externí odkaz:
https://doaj.org/article/05062f093ad34978985104ce9fcbc2bd
Autor:
Syed Nabeel-Shah, Jyoti Garg, Kanwal Ashraf, Renu Jeyapala, Hyunmin Lee, Alexandra Petrova, James D. Burns, Shuye Pu, Zhaolei Zhang, Jack F. Greenblatt, Ronald E. Pearlman, Jean-Philippe Lambert, Jeffrey Fillingham
Publikováno v:
Epigenetics & Chromatin, Vol 16, Iss 1, Pp 1-22 (2023)
Abstract Background Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. Such dynamic regulation is, in part, achieved through epigenetic modifications and selective incorporation of histone variants into
Externí odkaz:
https://doaj.org/article/e4f36e6d55c941bfb45b7fa551f9ce48
Autor:
Nassim Ledoux, Emeline I. J. Lelong, Alexandre Simard, Samer Hussein, Pauline Adjibade, Jean-Philippe Lambert, Rachid Mazroui
Publikováno v:
Cells, Vol 12, Iss 24, p 2807 (2023)
A deficiency of FMRP, a canonical RNA-binding protein, causes the development of Fragile X Syndrome (FXS), which is characterised by multiple phenotypes, including neurodevelopmental disorders, intellectual disability, and autism. Due to the alternat
Externí odkaz:
https://doaj.org/article/73c4e06e5c9c4e0fa2e8d02a4f26189b
Autor:
Sara L. Banerjee, Frédéric Lessard, François J.M. Chartier, Kévin Jacquet, Ana I. Osornio-Hernandez, Valentine Teyssier, Karim Ghani, Noémie Lavoie, Josée N. Lavoie, Manuel Caruso, Patrick Laprise, Sabine Elowe, Jean-Philippe Lambert, Nicolas Bisson
Publikováno v:
Cell Reports, Vol 40, Iss 1, Pp 111031- (2022)
Summary: EPH receptors (EPHRs) constitute the largest family among receptor tyrosine kinases in humans. They are mainly involved in short-range cell-cell communication events that regulate cell adhesion, migration, and boundary formation. However, th
Externí odkaz:
https://doaj.org/article/8fd2c903558b408894f403b0c0bd57f6
Autor:
Ugo Dionne, Émilie Bourgault, Alexandre K. Dubé, David Bradley, François J. M. Chartier, Rohan Dandage, Soham Dibyachintan, Philippe C. Després, Gerald D. Gish, N. T. Hang Pham, Myriam Létourneau, Jean-Philippe Lambert, Nicolas Doucet, Nicolas Bisson, Christian R. Landry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specific
Externí odkaz:
https://doaj.org/article/3eb0d24dbb7e42d98c601ea7d75ada6a
Autor:
Jérémy Loehr, Pata-Eting Kougnassoukou Tchara, Kevin Gonthier, Chahinez Noufi, Naomie Linteau, Étienne Audet-Walsh, Jean-Philippe Lambert
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
Cellular homeostasis requires the orderly expression of thousands of transcripts. Gene expression is regulated by numerous proteins that recognize post-translational modifications—in particular, the acetylation of lysine residues (Kac) on histones.
Externí odkaz:
https://doaj.org/article/8e2fa572180346cbaa9e0df926c64900
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Externí odkaz:
https://doaj.org/article/497bc78248de4d08a2f014f8d187bcc8
Autor:
Syed Nabeel-Shah, Jyoti Garg, Pata-Eting Kougnassoukou Tchara, Ronald E. Pearlman, Jean-Philippe Lambert, Jeffrey Fillingham
Publikováno v:
STAR Protocols, Vol 2, Iss 1, Pp 100362- (2021)
Summary: We describe an optimized protocol for one-step affinity purification of FZZ-tagged proteins followed by mass spectrometry analysis for the identification of protein-protein interactions in the ciliate protozoan Tetrahymena thermophila. The F
Externí odkaz:
https://doaj.org/article/4286ef92df364718915a1b61ea21a98f