Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jean-Philippe Gagne"'
Autor:
M Iqbal Hossain, Jun Hee Lee, Jean-Philippe Gagne, Junaid Khan, Guy G Poirier, Valina L Dawson, Ted M Dawson, Shaida A Anadrabi
PARP-1 over-activation results in cell death via excessive PAR generation in different cell types, including neurons following brain ischemia. Glycolysis, mitochondrial function, and redox balance are key cellular processes altered in brain ischemia.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a9d578b6058d8bd0942d157679c50a6
https://doi.org/10.1101/2023.05.30.542910
https://doi.org/10.1101/2023.05.30.542910
Autor:
Marie-Christine Caron, Ajit K. Sharma, Julia O’Sullivan, Logan R. Myler, Maria Tedim Ferreira, Amélie Rodrigue, Yan Coulombe, Chantal Ethier, Jean-Philippe Gagné, Marie-France Langelier, John M. Pascal, Ilya J. Finkelstein, Michael J. Hendzel, Guy G. Poirier, Jean-Yves Masson
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Poly(ADP-ribose) polymerase-1 (PARP-1) facilitates local chromatin relaxation and the recruitment of DNA repair factors at double strand breaks site (DSBs). Here the authors reveal that PARP-1 acts as a critical regulator of DNA end resection of DSBs
Externí odkaz:
https://doaj.org/article/9f5d756d157a42a383cdfc2eb5b3e5f7
Autor:
Julia O’Sullivan, Maria Tedim Ferreira, Jean-Philippe Gagné, Ajit K. Sharma, Michael J. Hendzel, Jean-Yves Masson, Guy G. Poirier
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
ADP-ribose erasing enzymes are increasingly recognized as critical regulators of protein ADP-ribosylation dynamics in living systems. Here, the authors review recent advances in the discovery and characterization of ADP-ribose erasers and discuss the
Externí odkaz:
https://doaj.org/article/05d8f39e0141460487e8fe00b0a3d6e4
Autor:
Anna Maggiore, Assunta Maria Casale, Walter Toscanelli, Ugo Cappucci, Dante Rotili, Maddalena Grieco, Jean-Philippe Gagné, Guy G. Poirier, Maria d’Erme, Lucia Piacentini
Publikováno v:
Cells, Vol 11, Iss 8, p 1284 (2022)
Alzheimer’s disease (AD) is an irreversible age-related neurodegenerative disorder clinically characterized by severe memory impairment, language deficits and cognitive decline. The major neuropathological hallmarks of AD include extracellular depo
Externí odkaz:
https://doaj.org/article/d9116e09e0184c0386e791bb036e7ba2
Autor:
Franck Chesnel, Anne Couturier, Adrien Alusse, Jean-Philippe Gagné, Guy G Poirier, Dominique Jean, François-Michel Boisvert, Pauline Hascoet, Luc Paillard, Yannick Arlot-Bonnemains, Xavier Le Goff
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009183 (2020)
Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Her
Externí odkaz:
https://doaj.org/article/3a166122c1164e179524bd21321b7177
Publikováno v:
Journal of Experimental Psychopathology, Vol 9 (2018)
Behavioral and cognitive models—as well as complementary theories such as the inference-based, mood-as-input, and seeking proxies for internal states approaches—have been put forward to explain the development and maintenance of obsessive–compu
Externí odkaz:
https://doaj.org/article/36892f7e7fec45c0a64e6e1229f2417b
Autor:
Giulia Bertolin, Anne-Laure Bulteau, Marie-Clotilde Alves-Guerra, Agnes Burel, Marie-Thérèse Lavault, Olivia Gavard, Stephanie Le Bras, Jean-Philippe Gagné, Guy G Poirier, Roland Le Borgne, Claude Prigent, Marc Tramier
Publikováno v:
eLife, Vol 7 (2018)
Many epithelial cancers show cell cycle dysfunction tightly correlated with the overexpression of the serine/threonine kinase Aurora A (AURKA). Its role in mitotic progression has been extensively characterised, and evidence for new AURKA functions e
Externí odkaz:
https://doaj.org/article/c41a0e3730934372b8b560ab43eb1bed
ARTD1/PARP1 Negatively Regulates Glycolysis by Inhibiting Hexokinase 1 Independent of NAD+ Depletion
Autor:
Elise Fouquerel, Eva M. Goellner, Zhongxun Yu, Jean-Philippe Gagné, Michelle Barbi de Moura, Tim Feinstein, David Wheeler, Philip Redpath, Jianfeng Li, Guillermo Romero, Marie Migaud, Bennett Van Houten, Guy G. Poirier, Robert W. Sobol
Publikováno v:
Cell Reports, Vol 8, Iss 6, Pp 1819-1831 (2014)
ARTD1 (PARP1) is a key enzyme involved in DNA repair through the synthesis of poly(ADP-ribose) (PAR) in response to strand breaks, and it plays an important role in cell death following excessive DNA damage. ARTD1-induced cell death is associated wit
Externí odkaz:
https://doaj.org/article/57881395c3964d75997386db9b9b638b
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86010 (2014)
Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo. Here we report crysta
Externí odkaz:
https://doaj.org/article/18e859faab4b4f74a9ef5e002b5465f7