Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jean-Philippe Courade"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Misfolded proteins in Alzheimer’s disease and Parkinson’s disease follow a well-defined connectomics-based spatial progression. Several anti-tau and anti-alpha synuclein (aSyn) antibodies have failed to provide clinical benefit in clinic
Externí odkaz:
https://doaj.org/article/1baaa5025ae842fab4f3f4ffb5de510a
Misfolded proteins in Alzheimer’s disease (AD) and Parkinson’s disease (PD) follow a well-defined connectomics-based spatial progression. Several anti-tau and anti-alpha synuclein (aSyn) antibodies have failed to provide clinical benefit in clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d625c6765b966dcae04d3cf509bc632
https://doi.org/10.21203/rs.3.rs-2799205/v1
https://doi.org/10.21203/rs.3.rs-2799205/v1
Publikováno v:
Drug discovery today. 27(11)
Significant efforts have been channeled into developing antibodies for the treatment of CNS indications. Disappointment with the first generation of clinical Tau antibodies in Alzheimer's disease has highlighted the challenges in understanding whethe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f84d9cd8a644ac17a1b74284214712d
https://pubmed.ncbi.nlm.nih.gov/35973661
https://pubmed.ncbi.nlm.nih.gov/35973661
Autor:
Berni Sweeney, Marta Westwood, Kerry Louise Tyson, David McMillan, Geofrey Odede, Gillian Burgess, Terry Baker, Daniel John Lightwood, Patrick Downey, Georges Mairet-Coello, Rebecca Munro, Martin Citron, Robert G. Griffin, Dale Starkie, Marie-Laetitia Mushikiwabo, Nathalie Pacico, Ruodan Nan, Sophie Jung, Rachel Angers, Jean-Philippe Courade, Andrew George Popplewell
Publikováno v:
Acta Neuropathologica
In Alzheimer’s disease (AD) and other tauopathies, the cytosolic protein Tau misfolds and forms intracellular aggregates which accumulate within the brain leading to neurodegeneration. Clinical progression is tightly linked to the progressive sprea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f67c24541a714f957c1f3282bf1205ce
https://doi.org/10.1007/s00401-018-1911-2
https://doi.org/10.1007/s00401-018-1911-2
Autor:
Jean-Philippe Courade, Joël Mercier, Michel Gillard, Jonas Hannestad, Delphine Viot, Georges Mairet-Coello, Martin Citron, Philippe Motte, Celine Vermeiren
Publikováno v:
Movement Disorders. 33:273-281
BACKGROUND Lilly/Avid's AV-1451 is one of the most advanced tau PET tracers in the clinic. Although results obtained in Alzheimer's disease patients are compelling, discrimination of tracer uptake in healthy individuals and patients with supranuclear
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4c262809f637fecd05b7537fc44b16
https://doi.org/10.1002/mds.27271
https://doi.org/10.1002/mds.27271
Autor:
Raphaëlle Caillierez, Mathieu Schmitt, Clément Danis, Martin Citron, Sébastien Carrier, Marie Albert, Luc Buée, Anne Michel, Isabelle Landrieu, Patrick Downey, Georges Mairet-Coello, Sarah Lieger, Emilie Skrobala, Morvane Colin, Jean-Philippe Courade
Publikováno v:
Brain-A Journal of Neurology
Brain-A Journal of Neurology, 2019, 142 (6), pp.1736-1750. ⟨10.1093/brain/awz100⟩
Brain
Brain-A Journal of Neurology, 2019, 142 (6), pp.1736-1750. ⟨10.1093/brain/awz100⟩
Brain
Immunotargeting of extracellular tau could slow the prion-like spreading of neurodegeneration. Albert et al. report that antibodies that recognize a central epitope on tau are the most effective at blocking both seeding and propagation of tau patholo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f759ffc1d64eb8b051ca6ca07995b4
https://www.hal.inserm.fr/inserm-02348408/document
https://www.hal.inserm.fr/inserm-02348408/document
Autor:
Jean-Philippe Courade, Martin Citron, Clément Danis, Sarah Lieger, Georges Mairet-Coello, Marie Albert, Luc Buée, Séverine Bégard, Raphaëlle Caillierez, Morvane Colin
Publikováno v:
Alzheimer's & Dementia. 14
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f8a7ca16dd28b24e43eb349d3e2e7578
https://doi.org/10.1016/j.jalz.2018.06.2937
https://doi.org/10.1016/j.jalz.2018.06.2937
Autor:
Caroline H. Johnson, Gary Siuzdak, Leah P. Shriver, Marianne Manchester, Linh Hoang, Gary J. Patti, Jean-Philippe Courade
Publikováno v:
Journal of Neuroimmune Pharmacology. 10:396-401
Therapeutic options for neuropathic pain have improved over the last 20 years yet still only provide partial relief with numerous side effects. Recently, metabolomics revealed that the concentration of the endogenous metabolite N,N-dimethylsphingosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f708a7e6516c95edba4129273da1af7
https://doi.org/10.1007/s11481-015-9624-y
https://doi.org/10.1007/s11481-015-9624-y
Autor:
Jean-Philippe Courade, Judith van Asperen, Olivier Lorthioir, Kyoko Koshibu, Helga Gerets, Javier Garcia-Ladona
Publikováno v:
Pharmacology. 96:240-247
Background/Aims: LRRK2 (leucine-rich repeat protein kinase 2) is one of the most commonly accepted genes associated with Parkinson's disease (PD). The overexpression of disease-associated mutations in LRRK2 is toxic to the cells, while reduction or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5745b6158eb9ca033dab6828c59b27ea
https://doi.org/10.1159/000439136
https://doi.org/10.1159/000439136
Autor:
Veronika Szombati, Misato Tsuge, Yun-Yun Zhan, Tsutomu Kawabe, Yun-Xuan Li, Jie Zu, Lucrezia Sarti, Young Lee, Qianqian He, Mariangela Manfredi, Toshinori Shiga, Oun-Cheol Back, Cheng-Cheng Yang, Komei Ito, Yan Lan, Tomohiro Nabekura, Martyn Harvey, Basim A.S. Messiha, Simona Barni, Judith van Asperen, Rong Hua, Xiang Fang, Frederik B. Pruijn, Jie Cai, Neri Pucci, Rita Benko, Elio Novembre, Wen-Zhe Jin, Zhen-He Wang, Hui Zhao, Lei Bao, Swarma Gamage, Eun-Seok Park, Kensuke Orito, Dae-Eun Kim, Olivier Lorthioir, Ji-Sook Lee, Helga Gerets, In Sik Kim, Tamas F. Molnar, Jin-Di Shi, Lisa Pecorari, Chun-Ping Chu, Istvan Benko, Kanae Mori, Yuka Kodera, Inas El Sayed Darwish, James Sleigh, Francesca Mori, Xinchun Ye, Da-Peng Dai, Yasmin Moustafa Ahmed, Guiyun Cui, Hong-Xia Pei, Su Zhou, William Denny, Nanako Ogasawara, Kyoko Koshibu, Iman Samy Dessouky, Yuta Tokai, Cha-Xiang Guan, Javier Garcia-Ladona, Ali Ahmed Abo-Saif, Loránd Barthó, Marika Shiga, Guo-Xin Hu, Miyoko Matsushima, Masahiro Yasui, Tatsuya Kawasaki, Hiroeki Sahara, Druckerei Stückle, Logan Voss, Yuichi Uwai, Hyung-Seok Jang, Jian-Ping Cai, Aya Omura, De-Lai Qiu, Jiney Jose, Jean-Philippe Courade, Heng Liu, Seiji Kojima
Publikováno v:
Pharmacology. 96:I-IV
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d78574d326162cd9c2da3bf6a42b850a
https://doi.org/10.1159/000442186
https://doi.org/10.1159/000442186