Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Jean-Philippe Carralot"'
Autor:
Matthew B. Wright, Javier Varona Santos, Christian Kemmer, Cyrille Maugeais, Jean-Philippe Carralot, Stephan Roever, Judith Molina, G. Michelle Ducasa, Alla Mitrofanova, Alexis Sloan, Anis Ahmad, Christopher Pedigo, Mengyuan Ge, Jeffrey Pressly, Laura Barisoni, Armando Mendez, Jacopo Sgrignani, Andrea Cavalli, Sandra Merscher, Marco Prunotto, Alessia Fornoni
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
This study describes a class of small molecule compounds that promote ABCA1-dependent cholesterol efflux via a non-transcriptional mechanism, the identification of the molecular target by a chemical biology approach, and the potential of these agents
Externí odkaz:
https://doaj.org/article/c5e4a9ac05ca4c609714e39b90c7084e
Autor:
Christophe J. Queval, Ok-Ryul Song, Jean-Philippe Carralot, Jean-Michel Saliou, Antonino Bongiovanni, Gaspard Deloison, Nathalie Deboosère, Samuel Jouny, Raffaella Iantomasi, Vincent Delorme, Anne-Sophie Debrie, Sei-Jin Park, Joana Costa Gouveia, Stanislas Tomavo, Roland Brosch, Akihiko Yoshimura, Edouard Yeramian, Priscille Brodin
Publikováno v:
Cell Reports, Vol 20, Iss 13, Pp 3188-3198 (2017)
Pathogens have evolved a range of mechanisms to counteract host defenses, notably to survive harsh acidic conditions in phagosomes. In the case of Mycobacterium tuberculosis, it has been shown that regulation of phagosome acidification could be achie
Externí odkaz:
https://doaj.org/article/c60ab7168e7d4646a016b88a181239ea
Autor:
Priscille Brodin, Yannick Poquet, Florence Levillain, Isabelle Peguillet, Gerald Larrouy-Maumus, Martine Gilleron, Fanny Ewann, Thierry Christophe, Denis Fenistein, Jichan Jang, Mi-Seon Jang, Sei-Jin Park, Jean Rauzier, Jean-Philippe Carralot, Rachel Shrimpton, Auguste Genovesio, Jesus A Gonzalo-Asensio, Germain Puzo, Carlos Martin, Roland Brosch, Graham R Stewart, Brigitte Gicquel, Olivier Neyrolles
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001100 (2010)
The ability of the tubercle bacillus to arrest phagosome maturation is considered one major mechanism that allows its survival within host macrophages. To identify mycobacterial genes involved in this process, we developed a high throughput phenotypi
Externí odkaz:
https://doaj.org/article/3fbdc7f8e69e49e48b8fb602f57de815
Autor:
Thierry Christophe, Mary Jackson, Hee Kyoung Jeon, Denis Fenistein, Monica Contreras-Dominguez, Jaeseung Kim, Auguste Genovesio, Jean-Philippe Carralot, Fanny Ewann, Eun Hye Kim, Sae Yeon Lee, Sunhee Kang, Min Jung Seo, Eun Jung Park, Henrieta Skovierová, Ha Pham, Giovanna Riccardi, Ji Youn Nam, Laurent Marsollier, Marie Kempf, Marie-Laure Joly-Guillou, Taegwon Oh, Won Kyung Shin, Zaesung No, Ulf Nehrbass, Roland Brosch, Stewart T Cole, Priscille Brodin
Publikováno v:
PLoS Pathogens, Vol 5, Iss 10, p e1000645 (2009)
A critical feature of Mycobacterium tuberculosis, the causative agent of human tuberculosis (TB), is its ability to survive and multiply within macrophages, making these host cells an ideal niche for persisting microbes. Killing the intracellular tub
Externí odkaz:
https://doaj.org/article/99417d33f11047f2814f85afb272f7e0
Autor:
Alla Mitrofanova, Jacopo Sgrignani, Judith Molina, Andrea Cavalli, Mengyuan Ge, Cyrille Maugeais, Alexis Sloan, Marco Prunotto, Laura Barisoni, G. Michelle Ducasa, Matthew Blake Wright, Christian Kemmer, Christopher E. Pedigo, Anis Ahmad, Javier Varona Santos, Stephan Roever, Jeffrey Pressly, Alessia Fornoni, Armando J. Mendez, Sandra Merscher, Jean-Philippe Carralot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications
Nature Communications
Impaired cellular cholesterol efflux is a key factor in the progression of renal, cardiovascular, and autoimmune diseases. Here we describe a class of 5-arylnicotinamide compounds, identified through phenotypic drug discovery, that upregulate ABCA1-d
Autor:
Quentin Carboué, Jean-Philippe Carralot, Eduardo Aranda-Delgado, Gerardo Saucedo-Castañeda, Isabelle Perraud-Gaime
Publikováno v:
Waste and Biomass Valorization
Waste and Biomass Valorization, 2021, 12 (11), pp.6057-6065. ⟨10.1007/s12649-021-01456-4⟩
Waste and Biomass Valorization, Springer, 2021, 12 (11), pp.6057-6065. ⟨10.1007/s12649-021-01456-4⟩
Waste and Biomass Valorization, 2021, 12 (11), pp.6057-6065. ⟨10.1007/s12649-021-01456-4⟩
Waste and Biomass Valorization, Springer, 2021, 12 (11), pp.6057-6065. ⟨10.1007/s12649-021-01456-4⟩
Coffee-pulp (CP) is an agricultural by-product produced in tropical regions. The high moisture and high carbohydrates content promote rapid spoilage by microorganisms together with detrimental consequences for the environment. Proper conservation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53d7b87329b59fb53abbad6fb51f6d99
https://amu.hal.science/hal-03400924
https://amu.hal.science/hal-03400924
Autor:
Jean-Philippe Carralot, Matilde Arévalo Ruiz, Robert Tam, Eric Armentani, Vijaya R. Pattabiraman, Bertolt Kreft
Publikováno v:
Cancer Research. 82:4223-4223
Immunocytokines (IC) provide the opportunity for targeted delivery of cytokines as payloads to tissues and cells to improve safety and efficacy of cytokine-based therapies. ICs have gained significant interest in recent years and several antibody-cyt
Autor:
Jean-Philippe Carralot, Rubén Alvarez Sanchez, Matilde Arévalo Ruiz, Magali Muller, Vijaya R. Pattabiraman, Bertolt Kreft
Publikováno v:
Cancer Research. 82:4224-4224
High-dose recombinant IL-2 (aldesleukin) is approved for treatment of advanced melanoma and renal cell carcinoma, however, major limitations restrict its therapeutic use. Wild-type IL-2 acts via binding to the medium-affinity IL-2 receptor βγ (IL2R
Autor:
Itxaso Bellon-Echeverria, Andrea Araujo Del Rosario, Jean Philippe Carralot, Imre Berger, Georg Schmid, Ralf Thoma, Harald Mauser, Stephanie Kueng
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Bellón-Echeverría, I, Carralot, J P, Del Rosario, A A, Kueng, S, Mauser, H, Schmid, G, Thoma, R & Berger, I 2018, ' MultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5-p25 protein-protein interaction (PPI) ', Scientific Reports, vol. 8, 5083 . https://doi.org/10.1038/s41598-018-23516-x
Scientific Reports
Bellón-Echeverría, I, Carralot, J P, Del Rosario, A A, Kueng, S, Mauser, H, Schmid, G, Thoma, R & Berger, I 2018, ' MultiBacMam Bimolecular Fluorescence Complementation (BiFC) tool-kit identifies new small-molecule inhibitors of the CDK5-p25 protein-protein interaction (PPI) ', Scientific Reports, vol. 8, 5083 . https://doi.org/10.1038/s41598-018-23516-x
Protein-protein interactions (PPIs) are at the core of virtually all biological processes in cells. Consequently, targeting PPIs is emerging at the forefront of drug discovery. Cellular assays which closely recapitulate native conditions in vivo are
Publikováno v:
BioEssays. 33:946-955
Multigene delivery and expression systems are emerging as key technologies for many applications in contemporary biology. We have developed new methods for multigene delivery and expression in eukaryotic hosts for a variety of applications, including