Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jean-Philippe Belzile"'
Autor:
Francine C A Gérard, Ruifeng Yang, Bizhan Romani, Alexis Poisson, Jean-Philippe Belzile, Nicole Rougeau, Éric A Cohen
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89195 (2014)
HIV viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/replication stress signalling pathway through engagement of the DDB1-CUL4A-DCAF1 E3 ubiquitin ligase via a direct binding to the substrate specif
Externí odkaz:
https://doaj.org/article/15fdd630252742abbec7d315a8da06ec
Publikováno v:
PLoS Pathogens, Vol 6, Iss 9, p e1001080 (2010)
HIV-1 Viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/stress checkpoint. Recently, we and several other groups showed that Vpr performs this activity by recruiting the DDB1-CUL4A (VPRBP) E3 ubiquit
Externí odkaz:
https://doaj.org/article/4fd3e0e5aa2d47b48bccb016a0eb3965
Autor:
Jean-Philippe Belzile, Ghislaine Duisit, Nicole Rougeau, Johanne Mercier, Andrés Finzi, Eric A Cohen
Publikováno v:
PLoS Pathogens, Vol 3, Iss 7, p e85 (2007)
Human immunodeficiency virus type 1 (HIV-1) viral protein R (Vpr) has been shown to cause G2 cell cycle arrest in human cells by inducing ATR-mediated inactivation of p34cdc2, but factors directly engaged in this process remain unknown. We used tande
Externí odkaz:
https://doaj.org/article/b498477901d44c698b3d59040c31826d
Autor:
Ruth Wang, Sarah Wise, Ben Niu, Todd C. Appleby, Michael L. Gross, Melanie Wong, Giuseppe A. Papalia, Jean-Philippe Belzile, Sheila Clancy, Latesh Lad, Armando G. Villaseñor, Johannes Voight, Mariya Morar, Katherine M. Brendza
Publikováno v:
Biochemistry
Blocking interactions between PD-1 and PD-L1 opens a new era of cancer treatment involving immunity modulation. Although most immunotherapies use monoclonal antibodies, small-molecule inhibitors offer advantages. To facilitate development of small-mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8574553f47281704646a2b2cf091a18
https://pubmed.ncbi.nlm.nih.gov/31841311
https://pubmed.ncbi.nlm.nih.gov/31841311
Autor:
Elizabeth Clark, Jean-Philippe Belzile, Megan Craig, Deborah H. Spector, Maite Sabalza, Christopher S. Morello
Publikováno v:
Journal of Virology. 90:1259-1277
Human cytomegalovirus (HCMV) is the major viral cause of birth defects and a serious problem in immunocompromised individuals and has been associated with atherosclerosis. Previous studies have shown that the induction of autophagy can inhibit the re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e6e9fc3ae1b4308f3d791e52400979f
https://doi.org/10.1128/jvi.02651-15
https://doi.org/10.1128/jvi.02651-15
Publikováno v:
Journal of Virology. 88:4021-4039
Congenital human cytomegalovirus (HCMV) infection is a major cause of central nervous system structural anomalies and sensory impairments. It is likely that the stage of fetal development, as well as the state of differentiation of susceptible cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4de2e51cc0915941564bf3fe433ec3b
https://doi.org/10.1128/jvi.03492-13
https://doi.org/10.1128/jvi.03492-13
Autor:
Brian A. Yee, Elizabeth Clark, Chelsea Gelboin-Burkhart, Shashank Sathe, Thomas J. Stark, Emily C. Wheeler, Frank Rigo, Stefan Aigner, Tomas Bos, Stephanie C. Huelga, Ranjan Batra, John Paul Donohue, Gene W. Yeo, Jean-Philippe Belzile, Hui Huang, Manuel Ares, Deborah H. Spector, Brett T Roberts
Publikováno v:
Nature structural & molecular biology, vol 23, iss 12
Nature structural & molecular biology
Nature structural & molecular biology
Host and virus interactions at the post-transcriptional level are critical for infection but remain poorly understood. Human cytomegalovirus (HCMV) is a prevalent herpesvirus family member that causes severe complications in immunocompromised patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::779ce7b301b0462b761d2cc0362c2652
https://escholarship.org/uc/item/8p8843dn
https://escholarship.org/uc/item/8p8843dn
Publikováno v:
Blood. 115:1354-1363
HIV up-regulates cell-surface expression of specific ligands for the activating NKG2D receptor, including ULBP-1, -2, and -3, but not MICA or MICB, in infected cells both in vitro and in vivo. However, the viral factor(s) involved in NKG2D ligand exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec59cdfee69e294c4dd363d1f455f53d
https://doi.org/10.1182/blood-2009-08-237370
https://doi.org/10.1182/blood-2009-08-237370
Autor:
Alexandre I, Belenkov, George, Shenouda, Ekatarina, Rizhevskaya, Denis, Cournoyer, Jean-Philippe, Belzile, Luis, Souhami, Slobodan, Devic, Terry Y K, Chow
Publikováno v:
Molecular Cancer Therapeutics. 3:1525-1532
Recent studies suggest that erythropoietin plays an important role in the process of neoplastic transformation and malignant phenotype progression observed in malignancy. To study the role of erythropoietin and its receptor (EPOR) on the response of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::078011f39fead9aba2a70690c01d7367
https://doi.org/10.1158/1535-7163.1525.3.12
https://doi.org/10.1158/1535-7163.1525.3.12
Autor:
Levon Abrahamyan, Éric A. Cohen, Nicole Rougeau, Francine C. A. Gérard, Jean-Philippe Belzile
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 6, Iss 9, p e1001080 (2010)
PLoS Pathogens, Vol 6, Iss 9, p e1001080 (2010)
HIV-1 Viral protein R (Vpr) induces a cell cycle arrest at the G2/M phase by activating the ATR DNA damage/stress checkpoint. Recently, we and several other groups showed that Vpr performs this activity by recruiting the DDB1-CUL4A (VPRBP) E3 ubiquit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b198027cda9fa484df9b17ff19e84ca0
https://pubmed.ncbi.nlm.nih.gov/21526938
https://pubmed.ncbi.nlm.nih.gov/21526938