New insights in the contribution of voltage-gated Na(v) channels to rat aorta contraction.

Autor: Aurélie Fort, Magali Cordaillat, Catherine Thollon, Guillermo Salazar, Ilana Mechaly, Nicole Villeneuve, Jean-Paul Vilaine, Sylvain Richard, Anne Virsolvy

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7360 (2009)

BACKGROUND: Despite increasing evidence for the presence of voltage-gated Na(+) channels (Na(v)) isoforms and measurements of Na(v) channel currents with the patch-clamp technique in arterial myocytes, no information is available to date as to whethe

Externí odkaz: https://doaj.org/article/91d0449526af42ba8e050217b751b7af

New Biologically Active Hydrogen Sulfide Donors

Autor: Marie-Pierre Bourguignon, Serge Simonet, Jean-Paul Vilaine, Nicole Villeneuve, Françoise Raynaud, Frédéric Bouillaud, Christine Crespo, Erwan Galardon, Isabelle Artaud, Thomas Roger, Céline Ransy

Publikováno v: ChemBioChem. 14:2268-2271

Generous donors: The dithioperoxyanhydrides (CH3 COS)2 , (PhCOS)2 , CH3 COSSCO2 Me and PhCOSSCO2 Me act as thiol-activated hydrogen sulfide donors in aqueous buffer solution. The most efficient donor (CH3 COS)2 can induce a biological response in cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b612f35d8a7dd1a0ab11b6be4e9155b
https://doi.org/10.1002/cbic.201300552

Development and validation of an enzyme-linked immunosorbent assay for the quantification of a specific MMP-9 mediated degradation fragment of type III collagen—A novel biomarker of atherosclerotic plaque remodeling

Autor: Jean-Paul Vilaine, Thomas C. Register, Nicole Villeneuve, Qinlong Zheng, Natasha Barascuk, Yu Cao, Christine Crespo, Morten A. Karsdal, Massimo Sabatini, Isabelle Lapret, Lars Melholt Rasmussen, J. Wang, Lise Larsen, Efstathios Vassiliadis, Rui Xing

Publikováno v: Barascuk, N, Vassiliadis, E, Larsen, L, Wang, J, Zheng, Q, Xing, R, Cao, Y, Crespo, C, Lapret, I, Sabatini, M, Villeneuve, N, Vilaine, J-P, Rasmussen, L M, Register, T C & Karsdal, M A 2011, ' Development and validation of an enzyme-linked immunosorbent assay for the quantification of a specific MMP-9 mediated degradation fragment of type III collagen--A novel biomarker of atherosclerotic plaque remodeling ', Clinical Biochemistry, vol. 44, no. 10-11, pp. 900-906 . https://doi.org/10.1016/j.clinbiochem.2011.04.004

Degradation of collagen in the arterial wall by matrix metalloproteinases is the hallmark of atherosclerosis. We have developed an ELISA for the quantification of type III collagen degradation mediated by MMP-9 in urine.A monoclonal antibody targetin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d6634faf1d850b150875329f0586e5f
https://doi.org/10.1016/j.clinbiochem.2011.04.004

Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity

Autor: Francis Cogé, Pascale Chomarat, Guillaumin Jp, Stephane Bedut, Brunel-Jacquemin C, Jean-Louis Peglion, Piffard L, Nicole Villeneuve, Catherine Thollon, Jean A. Boutin, Jean-Paul Vilaine

Publikováno v: British Journal of Pharmacology. 150:37-46

Background and purpose: Ivabradine, a specific and use-dependent If inhibitor, exerts anti-ischaemic activity purely by reducing heart rate. The aim of this work was to characterize its effect on the predominant HCN channel isoform expressed in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a112514f16c2f806606d22613c045ca7
https://doi.org/10.1038/sj.bjp.0706940

Chronic Mild Hyperhomocysteinemia Induces Aortic Endothelial Dysfunction but Does Not Elevate Arterial Pressure in Rats

Autor: Chao-Yu Miao, Cyril Briant, Jean-Paul Vilaine, Nicole Villeneuve, Paul M. Vanhoutte, Christine Brunel-Jacquemin, Denis Gransagne, Jean-Philippe Guillaumin, Christine Petit

Publikováno v: Journal of Vascular Research. 42:148-156

Mild hyperhomocysteinemia is prevalent in the general population and has been linked to endothelial dysfunction and high arterial pressure (AP) in clinical studies. The present study was designed to determine whether a rise in AP was induced by mild

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6810480f93d7c81b228a36a0071eb73
https://doi.org/10.1159/000083972