Differences in the miRNA signatures of chronic musculoskeletal pain patients from neuropathic or nociceptive origins

Autor: Charles Benaim, Bertrand Léger, Philippe Vuistiner, Joane Le Carré, François Luthi, Philippe Terrier, Camille Florine Dayer, Jean-Paul Giacobino

Publikováno v: PloS one, vol. 14, no. 7, pp. e0219311
PLoS ONE
PLoS ONE, Vol 14, Iss 7, p e0219311 (2019)

BackgroundThe quality of life for millions of people worldwide is affected by chronic pain. In addition to the effect of chronic pain on well-being, chronic pain has also been associated with poor health conditions and increased mortality. Due to its

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf4852c69eb4ce32829032f742fc5e2
https://serval.unil.ch/notice/serval:BIB_57623B349BC7

Thermogenic brown adipocytes as new targets for the treatment of obesity in humans

Autor: Jean-Paul Giacobino, Louis Casteilla

Publikováno v: Clinical Lipidology. 5:173-180

In rodents, brown adipose tissue, owing to its unique thermogenic uncoupling protein-1, is the main effector of adaptative thermogenesis. In humans, it was generally accepted that brown adipose tissue was present only in newborns. White adipose tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f2718d3490113239ac953f2e34e3104
https://doi.org/10.2217/clp.10.5

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

Autor: Bruno Péault, Johnny Huard, Jeremy Traas, Bridget M. Deasy, Cyrille Norotte, Rebecca C. Schugar, Mihaela Crisan, Jean-Paul Giacobino, Hans-Jörg Bühring, Mirko Corselli, Gabriella Andriolo, Lorenza Lazzari, Li Zhang, Bin Sun, Stephen F. Badylak, Chien Wen Chen, Tea Soon Park, Bo Zheng, Louis Casteilla, Pang-ning Teng, Solomon Yap

Publikováno v: Crisan, M, Yap, S, Casteilla, L, Chen, C-W, Corselli, M, Park, T S, Andriolo, G, Sun, B, Zheng, B, Zhang, L, Norotte, C, Teng, P-N, Traas, J, Schugar, R, Deasy, B M, Badylak, S, Buehring, H-J, Giacobino, J-P, Lazzari, L, Huard, J & Peault, B 2008, ' A perivascular origin for mesenchymal stem cells in multiple human organs ', Cell Stem Cell, vol. 3, no. 3, pp. 301-313 . https://doi.org/10.1016/j.stem.2008.07.003

Mesenchymal stem cells (MSCs), the archetypal multipotent progenitor cells derived in cultures of developed organs, are of unknown identity and native distribution. We have prospectively identified perivascular cells, principally pericytes, in multip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425bb14d6827c6433dd3dc16e673aa5c

Norepinephrine Induces Lipolysis in β1/β2/β3-Adrenoceptor Knockout Mice

Autor: Max Lafontan, Maria Jimenez, Nicolas Hulo, Jean-Paul Giacobino, Geneviève Tavernier, Dominique Langin, Patrick Muzzin

Publikováno v: Molecular Pharmacology. 68:793-799

Catecholamines are major stimulants of adipose tissue metabolism. Norepinephrine and epinephrine act through three subtypes of beta-adrenoceptors (beta-AR) expressed in the adipocytes. The aim of this work was to study the mechanisms of lipid mobiliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3b3dbf67d1f85ba2ab61b9be49894c25
https://doi.org/10.1124/mol.105.014670

β3-Adrenoceptor knockout in C57BL/6J mice depresses the occurrence of brown adipocytes in white fat

Autor: Jean-Paul Giacobino, Giorgio Barbatelli, Saverio Cinti, Patrick Muzzin, Maria Jimenez, Frédéric Preitner, Roberta Allevi, Josiane Seydoux

Publikováno v: European Journal of Biochemistry. 270:699-705

White and brown adipocytes are usually located in distinct depots; however, in response to cold, brown adipocytes appear in white fat. This response is mediated by β-adrenoceptors but there is a controversy about the subtype(s) involved. In the pres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::94ecfd4754a199f4c36dafe1b8418241
https://doi.org/10.1046/j.1432-1033.2003.03422.x