Výsledky vyhledávání - "Jean-Paul Charlieu"

A zinc finger truncation of murine WT1 results in the characteristic urogenital abnormalities of Denys–Drash syndrome

Autor: Sheila Christie, Alan Richard Clarke, Jean Paul Charlieu, Melissa H. Little, Martin L. Hooper, Nicholas D. Hastie, Colin G. Miles, David J. Harrison, David J. Porteous, Jennifer Doig, Stewart Fleming, Kiyoshi Miyagawa, Anthony J. Brookes, Charles E. Patek

Publikováno v: Proceedings of the National Academy of Sciences. 96:2931-2936

The Wilms tumor-suppressor gene, WT1 , plays a key role in urogenital development, and WT1 dysfunction is implicated in both neoplastic (Wilms tumor, mesothelioma, leukemias, and breast cancer) and nonneoplastic (glomerulosclerosis) disease. The anal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::180d837a6470afc197b4738fcc8980aa
https://doi.org/10.1073/pnas.96.6.2931

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Primed in situ (PRINS) Labelling with Alu and Satellite Primers for Rapid Characterization of Human Chromosomes in Hybrid Cell Lines

Autor: Jean Paul Charlieu, Brigitte Andréo, Jean-Jacques Candelier, Philippe Coullin, Franck Pellestor

Publikováno v: Chromosome Research. 5:307-312

The primed in situ (PRINS) labelling method was developed as an alternative to classical cytogenetics and fluorescence in situ hybridization (FISH) for the characterization of interspecific somatic hybrids. Full karyotypes were performed by PRINS usi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27aaf430f44be1cfbb77cba5d5ab6846
https://doi.org/10.1023/b:chro.0000038761.15856.4d

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Preimplantation embryo chromosome analysis by primed in situ labeling method

Autor: Anne Girardet, Geneviève Lefort, Jean Paul Charlieu, Brigitte Andréo, Franck Pellestor

Publikováno v: Fertility and Sterility. 66:781-786

Objective To present the use of primed in situ labeling method in preimplantation diagnosis. Design Double- and triple-primed in situ labeling were performed on 10 morphologically abnormal preimplantation embryos, using combinations of specific prime

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbc2834f005233ed51d94583e0fc41e2
https://doi.org/10.1016/s0015-0282(16)58636-1

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Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

Autor: Kiyoshi Miyagawa, Nicholas D. Hastie, Jean-Paul Charlieu, Veronica van Heyningen, Stefan H Larsson, Dieter Engelkamp, François Cuzin, Minoo Rassoulzadegan, Allyson Ross

Publikováno v: Cell. 81:391-401

WT1 is a tumor suppressor gene with a key role in urogenital development and the pathogenesis of Wilms' tumor. Two alternative splice sites in the WT1 transcript allow the gene to encode four proteins. These carry four Krüppel-type zinc fingers and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59cc66e514efa2e16660767c5193047b
https://doi.org/10.1016/0092-8674(95)90392-5

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Does the Wilms’ tumour suppressor gene, WT1, play roles in both splicing and transcription?

Autor: Jean-Paul Charlieu, Kiyoshi Miyagawa, Veronica van Heyningen, Nicholas D. Hastie, Stefan H Larsson

Publikováno v: Scopus-Elsevier

SUMMARY The Wilms’ tumour suppressor gene (WT1) encodes a protein(s) with 4 zinc fingers that is essential for the development of the genitourinary system. A considerable body of evidence exists to support the idea that WT1 binds DNA and functions

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8ba9c3a3852522d1d4c2b7e47e9aae3
https://doi.org/10.1242/jcs.1995.supplement_19.14

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Organization of the variant domains of α satellite DNA on human chromosome 21

Autor: Jean-Paul Charlieu, Gérard Roizès, Anne-Marie Laurent, B. Marçais

Publikováno v: Journal of Molecular Evolution. 37:171-178

The de novo creation of long, homogeneous, satellite DNA domains was postulated previously to occur by saltatory amplification. In this paper, pulsed field gel electrophoresis analysis of the alpha satellite DNA block organization of the human chromo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e9627c0b044a4859fcdfbb12a780c39
https://doi.org/10.1007/bf02407353

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3′ Alu PCR: a simple and rapid method to isolate human polymorphic markers

Autor: Gérard Roizès, M. Bellis, Dee A. Carter, Jean-Paul Charlieu, Anne-Marie Laurent

Publikováno v: Nucleic Acids Research. 20:1333-1337

Microsatellites, such as (TG)n found at random throughout the genome, or as 3' extensions of Alu sequences are being increasingly used as genetic markers because of their pluriallelic character. The search for polymorphic microsatellites is time cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae97902d14e0c2199b82eb653bbc70c
https://doi.org/10.1093/nar/20.6.1333

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On the mode of evolution of alpha satellite DNA in human populations

Autor: B. Marçais, E. Brun, Gérard Roizès, M. Bellis, Jean-Paul Charlieu, B. Allain

Publikováno v: Journal of Molecular Evolution. 33:42-48

The hypothesis that highly reiterated satellite DNAs in present-day populations evolve by molecular mechanisms that create, by saltatory amplification steps, new long arrays of satellite DNA, and that such long arrays are used for homogenization purp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cf15cee2b7f5c510112c6d869529a2
https://doi.org/10.1007/bf02100194

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