Zobrazeno 1 - 10
of 155
pro vyhledávání: '"Jean-Paul Behr"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss , Pp 483-492 (2018)
We report the evaluation of 18-mer 2′-O-methyl-modified ribose oligonucleotides with a full-length phosphorothioate backbone chemically conjugated at the 5′ end to the oligospermine units (Sn-: n = 5, 15, 20, 25, and 30 [number of spermine units]
Externí odkaz:
https://doaj.org/article/c3f230b50ab44ad0bb3ef0b0af083011
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 13, Iss, Pp 483-492 (2018)
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Elsevier, 2018, 13, pp.483-492. ⟨10.1016/j.omtn.2018.09.027⟩
Molecular Therapy. Nucleic Acids
Molecular Therapy-Nucleic Acids
Molecular Therapy-Nucleic Acids, Elsevier, 2018, 13, pp.483-492. ⟨10.1016/j.omtn.2018.09.027⟩
Molecular Therapy. Nucleic Acids
We report the evaluation of 18-mer 2′-O-methyl-modified ribose oligonucleotides with a full-length phosphorothioate backbone chemically conjugated at the 5′ end to the oligospermine units (Sn-: n = 5, 15, 20, 25, and 30 [number of spermine units]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fd72c1b5dca8ee1fe4ae3da4f73c27a
http://www.sciencedirect.com/science/article/pii/S2162253118302725
http://www.sciencedirect.com/science/article/pii/S2162253118302725
Autor:
Jean-Paul Behr
Publikováno v:
CHIMIA, Vol 51, Iss 1-2 (1997)
Several non-permanent polycations possessing substantial buffering capacity below physiological pH, such as lipopolyamines and polyethylenimines, are efficient transfection agents per se, i.e. without the addition of lysosomotropic bases, or cell tar
Externí odkaz:
https://doaj.org/article/d11194c572e546c7803f05d07a039d80
Publikováno v:
Molecular Pharmaceutics
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (8), pp.2718-2728. ⟨10.1021/acs.molpharmaceut.6b00309⟩
Molecular Pharmaceutics, American Chemical Society, 2016, 13 (8), pp.2718-2728. ⟨10.1021/acs.molpharmaceut.6b00309⟩
Oligospermine-siRNA conjugates are able to induce efficient luciferase gene silencing upon carrier-free transfection. These conjugates are readily accessible by a versatile automated chemistry that we developed using a DMT-spermine phosphoramidite re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5f2f4dde5df46e35a0c2be93aa6079
https://doi.org/10.1021/acs.molpharmaceut.6b00309
https://doi.org/10.1021/acs.molpharmaceut.6b00309
Autor:
Jean-Paul Behr, Marc Nothisen, Jean-Serge Remy, Mitsuharu Kotera, Jérémy Bagilet, Phanélie Perche
Publikováno v:
Journal of Controlled Release. 170:92-98
Despite its considerable interest in human therapy, in vivo siRNA delivery is still suffering from hurdles of vectorization. We have shown recently efficient gene silencing by non-vectorized cationic siRNA. Here, we describe the synthesis and in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a023a67c3d862aadb3c98f665f84cfd
https://doi.org/10.1016/j.jconrel.2013.04.013
https://doi.org/10.1016/j.jconrel.2013.04.013
Autor:
Tianzhu Yu, Xiaoxuan Liu, Anne‐Laure Bolcato‐Bellemin, Yang Wang, Cheng Liu, Patrick Erbacher, Fanqi Qu, Palma Rocchi, Jean‐Paul Behr, Ling Peng
Publikováno v:
Angewandte Chemie. 124:8606-8612
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7529c8846d54de9751afd321f41824a4
https://doi.org/10.1002/ange.201203920
https://doi.org/10.1002/ange.201203920
Autor:
Patrick Erbacher, Anne-Laure Bolcato-Bellemin, Marie-Elise Bonnet, Jean-Paul Behr, Gaëlle Creusat
Publikováno v:
Proceedings of the National Academy of Sciences. 104:16050-16055
siRNA delivery to cells offers a convenient and powerful means of gene silencing that bypasses several barriers met by gene delivery. However, nonviral vectors, and especially polymers, form looser complexes with siRNA than with plasmid DNA. As a con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6c2f6922ac1fdfc42c2663e5661ad9
https://doi.org/10.1073/pnas.0707831104
https://doi.org/10.1073/pnas.0707831104
Publikováno v:
Journal of the American Chemical Society. 128:10763-10771
Oligonucleotide delivery is a crucial issue for therapeutical purposes and is often addressed by conjugation to short cationic peptides although with controversial results. To further examine this mechanism, a 15-mer anionic oligonucleotide was conju
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43fa3b134d941e6c9dfa5a80b8a48987
https://doi.org/10.1021/ja060873e
https://doi.org/10.1021/ja060873e
Autor:
Patrick Erbacher, Alioune Ndoye, Jean-Louis Merlin, Alexandre Fifre, Jean-Paul Behr, François Guillemin, Anders Høgset, Gilles Dolivet, Agnès Leroux, Kristian Berg
Publikováno v:
Mol. Ther.
Mol. Ther., 2006, 13, pp.1156-1162
Mol. Ther., 2006, 13, pp.1156-1162
Photochemical internalization (PCI) technology has been used for PEI-mediated p53 gene transfer in mice bearing head and neck squamous cell carcinoma (HNSCC) xenografts. Using luciferase as a reporter gene, PCI led to a 20-fold increase in transgene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14222b644c4d89a8e28a5677ef31860b
Autor:
Zahra Hassani, Karima Palmier, Patrick Erbacher, Gregory F. Lemkine, Gladys Alfama, Barbara A. Demeneix, Jean-Paul Behr, Carine Giovannangeli
Publikováno v:
The Journal of Gene Medicine
The Journal of Gene Medicine, Wiley, 2005, 7 (2), pp.198-207. ⟨10.1002/jgm.659⟩
The Journal of Gene Medicine, Wiley, 2005, 7 (2), pp.198-207. ⟨10.1002/jgm.659⟩
BACKGROUND: Efficient in vivo vectors are needed to exploit the enormous potential of RNA interference (RNAi). Such methods require optimisation for specific delivery routes, tissues and usages. We tested the capacity of different non-viral vectors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a0a64fc02dde13ac74632815338f5e
https://doi.org/10.1002/jgm.659
https://doi.org/10.1002/jgm.659