CNCA aligns small annotated genomes

Autor: Jean-Noël Lorenzi, François Graner, Virginie Courtier-Orgogozo, Guillaume Achaz

Publikováno v: BMC Bioinformatics, Vol 25, Iss 1, Pp 1-4 (2024)

Abstract Background To explore the evolutionary history of sequences, a sequence alignment is a first and necessary step, and its quality is crucial. In the context of the study of the proximal origins of SARS-CoV-2 coronavirus, we wanted to construc

Externí odkaz: https://doaj.org/article/ace9c721d87c4923b2543bd3c4cd3250

Massive Gene Flux Drives Genome Diversity between Sympatric Streptomyces Conspecifics

Autor: Abdoul-Razak Tidjani, Jean-Noël Lorenzi, Maxime Toussaint, Erwin van Dijk, Delphine Naquin, Olivier Lespinet, Cyril Bontemps, Pierre Leblond

Publikováno v: mBio, Vol 10, Iss 5 (2019)

ABSTRACT In this work, by comparing genomes of closely related individuals of Streptomyces isolated at a spatial microscale (millimeters or centimeters), we investigated the extent and impact of horizontal gene transfer in the diversification of a na

Externí odkaz: https://doaj.org/article/ff96284dea1648d4a50d21b447b6311a

Ribosomal RNA operons define a central functional compartment in the Streptomyces chromosome

Autor: Jean-Noël Lorenzi, Annabelle Thibessard, Virginia S. Lioy, Frédéric Boccard, Pierre Leblond, Jean-Luc Pernodet, Stéphanie Bury-Moné

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, 50 (20), pp.11654-11669. ⟨10.1093/nar/gkac1076⟩

Streptomyces are prolific producers of specialized metabolites with applications in medicine and agriculture. These bacteria possess a large linear chromosome genetically compartmentalized: core genes are grouped in the central part, while terminal r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dbd5993685c68686414830f3ac5386b
https://pubmed.ncbi.nlm.nih.gov/36408918

Dynamics of the compartmentalized Streptomyces chromosome during metabolic differentiation

Autor: Nelle Varoquaux, Bertrand Aigle, Sylvie Lautru, Jean-Noël Lorenzi, Corinne Saulnier, Jean-Luc Pernodet, Ivan Junier, Virginia S. Lioy, Yan Jaszczyszyn, Kevin Gorrichon, Hervé Leh, Frédéric Boccard, Thibault Poinsignon, Soumaya Najah, Pierre Leblond, Stéphanie Bury-Moné, Annabelle Thibessard, Olivier Lespinet

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩
Nature Communications, Nature Publishing Group, 2021, 12 (1), ⟨10.1038/s41467-021-25462-1⟩
BioRxiv
Nature Communications, 2021, 12, pp.5221. ⟨10.1038/s41467-021-25462-1⟩
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Bacteria of the genus Streptomyces are prolific producers of specialized metabolites, including antibiotics. The linear chromosome includes a central region harboring core genes, as well as extremities enriched in specialized metabolite biosynthetic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277c6baa0aecb3b4d45b4196a94f7624
https://doi.org/10.21203/rs.3.rs-145840/v1

Subtelomeres are fast-evolving regions of the Streptomyces linear chromosome

Autor: Pierre Leblond, Jean-Noël Lorenzi, Annabelle Thibessard, Olivier Lespinet

Publikováno v: Microbial Genomics
Microbial Genomics, 2021, ⟨10.1099/mgen.0.000525⟩
Microbial Genomics, Society for General Microbiology, 2021, ⟨10.1099/mgen.0.000525⟩
Microbial Genomics, Society for General Microbiology, In press, ⟨10.1099/mgen.0.000525⟩

Streptomycespossess a large linear chromosome (6–12 Mb) consisting of a conserved central region flanked by variable arms covering several megabases. In order to study the evolution of the chromosome across evolutionary times, a representative pane

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acbf2423a9bc033502acb6bcb5f45b4
https://doi.org/10.1099/mgen.0.000525