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pro vyhledávání: '"Jean-Michel Roul"'
Autor:
Klaus Fleischmann, H. Jendralla, Christian Lefebvre, Theo Wollmann, Walter Dr. Dürckheimer, Winfried Hertzsch, Rolf Horlein, Friedhelm Adam, Jean-Michel Roul, Philippe Mackiewicz
Publikováno v:
Liebigs Annalen. 1996:1735-1741
An efficient synthesis of HR 916 B (4), the orally active 1-(RS)-(pivaloyloxy)ethyl prodrug ester of the cephalosporin cefdaloxime, was developed and applied on a multi-kg scale. AMCA (8) was prepared by exchange of the acetoxy group of fermentation