Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Jean-Michel Guillon"'
Autor:
F. Alberto Abreu-Grobois, B. Alejandra Morales-Mérida, Catherine E. Hart, Jean-Michel Guillon, Matthew H. Godfrey, Erik Navarro, Marc Girondot
Publikováno v:
PeerJ, Vol 8, p e8451 (2020)
Temperature-dependent sex determination, or TSD, is a widespread phenomenon in reptiles. The shape of the relationship between constant incubation temperature and sex ratio defines the TSD pattern. The TSD pattern is considered a life-history paramet
Externí odkaz:
https://doaj.org/article/5f121dc9dbc14d18afcb5af81f6fce7f
Autor:
Patrice Bellevergue, Klaus Steinmeyer, Michel Pelat, Suzanne Marque, John Weston, Nils Rackelmann, Jean-Michel Guillon, Petra Arndt, Thomas Lartigue, Philip Janiak, Veronique Ballet, Gary Mccort, Laetitia Ly-Nguyen, Frédérique Chézalviel-Guilbert, Heinz Gögelein, Fabrice Barbe, Marie-Pierre Pruniaux-Harnist, Georges Tavares, Cyril Daveu, Marc Trellu, Laurence Lucats, Philippe Beauverger, Klaus Wirth
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 377:293-304
In failing hearts, Na+/Ca2+ exchanger (NCX) overactivity contributes to Ca2+ depletion, leading to contractile dysfunction. Inhibition of NCX is expected to normalize Ca2+ mishandling, to limit afterdepolarization-related arrhythmias, and to improve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::816369d0babbe203ceed48952ab75eca
https://doi.org/10.1124/jpet.120.000238
https://doi.org/10.1124/jpet.120.000238
Autor:
Nicolas Couvreur, Charles Benson, Jean-Michel Guillon, Yoshiko Okai, Armando Lagrutta, Todd Wisialowski, Michael G. Rolf, Ard Teisman, C. Michael Foley, Hugo M. Vargas, Jean-Pierre Valentin, Maki Ito, Michael J. Engwall, Khuram W. Chaudhary, Gary Gintant, David J. Gallacher, Takashi Yoshinaga, Andrea Greiter-Wilke, Corina Dota, Paul Levesque, Katsuyoshi Chiba, Amy Pointon, Stephen Jenkinson, Anthony Bahinski, Martin Traebert, Brian Guth, Eric Martel, Alan S. Bass, Christa Hegele‐Hartung, William E. Achanzar, Ravikumar Peri, Herbert M. Himmel, Yusheng Qu, Derek J. Leishman
Publikováno v:
Clinical Pharmacology and Therapeutics
Defining an appropriate and efficient assessment of drug‐induced corrected QT interval (QTc) prolongation (a surrogate marker of torsades de pointes arrhythmia) remains a concern of drug developers and regulators worldwide. In use for over 15 years
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::527f989fd8c7a31101405fa082c754d4
https://doi.org/10.1002/cpt.2029
https://doi.org/10.1002/cpt.2029
Autor:
Jean-Pierre Bidouard, Fabrice Barbe, Bruno Poirier, Philippe Beauverger, Philip Janiak, Frédéric Petit, Paul J. Schaeffer, Marie-Laure Ozoux, Michel Pelat, Véronique Briand, Jean-Michel Guillon, Jean-Michel Altenburger
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 374:24-37
Chronic kidney disease (CKD) remains a common disorder, leading to growing health and economic burden without curative treatment. In diabetic patients, CKD may result from a combination of metabolic and nonmetabolic-related factors, with mortality ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::263ed2eef8f17107cfac3577e5dfc46c
https://doi.org/10.1124/jpet.120.265496
https://doi.org/10.1124/jpet.120.265496
Autor:
Mohammed H Cherkaoui-Rbati, Roland A. Cooper, Nina F. Gnädig, Iñigo Angulo-Barturen, Tomas Yeo, Sridevi Bashyam, Rintis Noviyanti, James M. Murithi, Gilles Courtemanche, Philip J. Rosenthal, María Belén Jiménez-Díaz, Laurent Sallé, Cécile Pascal, Rita Merino, Gilles Tuffal, Jutta Marfurt, Sergio Wittlin, Shivendra Singh, Marie José Cabanis, Lidiya Bebrevska, Jean Michel Augereau, Laura M. Sanz, Jean Michel Guillon, Sachel Mok, Paul Desert, Kelly Rubiano, Alain Pellet, Jacquin C. Niles, Guillaume Louit, Anne-Catrin Uhlemann, Nadir Bessila, Thierry Vermat, Simon Campbell, Didier Leroy, Tanguy Bozec, Jérôme Menegotto, Michel Doubovetzky, Xavier Boulenc, Benjamin Blasco, Nathalie Gobeau, Francisco-Javier Gamo, Sylvie Klieber, Elie Giraud, Jayan Joseph, Charisse Flerida A. Pasaje, Delphine Baud, Laurent Fraisse, Fanny Escudié, Jade Bath, Marie Françoise Nicolas, Mélanie Rouillier, David A. Fidock, Grennady Wirjanata, Ric N. Price, Patrick K Tumwebaze
The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70c2e27d8190f65306f8587a21d03126
https://ora.ox.ac.uk/objects/uuid:39d2c646-efac-4c3d-bdef-8cf1ff7f497f
https://ora.ox.ac.uk/objects/uuid:39d2c646-efac-4c3d-bdef-8cf1ff7f497f
Autor:
Gregory S. Friedrichs, David G. Strauss, Ariane Menard, Jill Steidl-Nichols, Jean-Michel Guillon, Nicolas Gendron-Parra, Simon Authier, Jean-Pierre Valentin, Ray W. Chui, Jennifer B. Pierson, Michael K. Pugsley, Eric I. Rossman, Todd Wisialowski, Matthew M. Abernathy, Emmanuel Boulay, John Koerner, Andrea Greiter-Wilke, Eric Troncy
Publikováno v:
International Journal of Toxicology. 38:23-32
Introduction: Based on the ICH S7B and E14 guidance documents, QT interval (QTc) is used as the primary in vivo biomarker to assess the risk of drug-induced torsades de pointes (TdP). Clinical and nonclinical data suggest that drugs that prolong the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef70e5850a2a9fe87809255931a38c98
https://doi.org/10.1177/1091581818813601
https://doi.org/10.1177/1091581818813601
Autor:
James M, Murithi, Cécile, Pascal, Jade, Bath, Xavier, Boulenc, Nina F, Gnädig, Charisse Flerida A, Pasaje, Kelly, Rubiano, Tomas, Yeo, Sachel, Mok, Sylvie, Klieber, Paul, Desert, María Belén, Jiménez-Díaz, Jutta, Marfurt, Mélanie, Rouillier, Mohammed H, Cherkaoui-Rbati, Nathalie, Gobeau, Sergio, Wittlin, Anne-Catrin, Uhlemann, Ric N, Price, Grennady, Wirjanata, Rintis, Noviyanti, Patrick, Tumwebaze, Roland A, Cooper, Philip J, Rosenthal, Laura M, Sanz, Francisco Javier, Gamo, Jayan, Joseph, Shivendra, Singh, Sridevi, Bashyam, Jean Michel, Augereau, Elie, Giraud, Tanguy, Bozec, Thierry, Vermat, Gilles, Tuffal, Jean-Michel, Guillon, Jérôme, Menegotto, Laurent, Sallé, Guillaume, Louit, Marie-José, Cabanis, Marie Françoise, Nicolas, Michel, Doubovetzky, Rita, Merino, Nadir, Bessila, Iñigo, Angulo-Barturen, Delphine, Baud, Lidiya, Bebrevska, Fanny, Escudié, Jacquin C, Niles, Benjamin, Blasco, Simon, Campbell, Gilles, Courtemanche, Laurent, Fraisse, Alain, Pellet, David A, Fidock, Didier, Leroy
Publikováno v:
Sci Transl Med
The emergence and spread of Plasmodium falciparum resistance to first-line antimalarials creates an imperative to identify and develop potent preclinical candidates with distinct modes of action. Here, we report the identification of MMV688533, an ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f0efda724d23dde7d58c5a209b92e0ae
https://pubmed.ncbi.nlm.nih.gov/34290058
https://pubmed.ncbi.nlm.nih.gov/34290058
Publikováno v:
Integrative And Comparative Biology (1540-7063) (Oxford Univ Press Inc), 2020-12, Vol. 60, N. 6, P. 1347-1350
Integrative and Comparative Biology
Integrative and Comparative Biology, Oxford University Press (OUP), 2020, 60 (6), pp.1347-1350. ⟨10.1093/icb/icaa139⟩
Integrative and Comparative Biology
Integrative and Comparative Biology, Oxford University Press (OUP), 2020, 60 (6), pp.1347-1350. ⟨10.1093/icb/icaa139⟩
International audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11bafd83a9e592ac0230853e0bfbef3a
https://archimer.ifremer.fr/doc/00733/84473/
https://archimer.ifremer.fr/doc/00733/84473/
Autor:
Michel, Pelat, Fabrice, Barbe, Cyril, Daveu, Laetitia, Ly-Nguyen, Thomas, Lartigue, Suzanne, Marque, Georges, Tavares, Véronique, Ballet, Jean-Michel, Guillon, Klaus, Steinmeyer, Klaus, Wirth, Heinz, Gögelein, Petra, Arndt, Nils, Rackelmann, John, Weston, Patrice, Bellevergue, Gary, McCort, Marc, Trellu, Laurence, Lucats, Philippe, Beauverger, Marie-Pierre, Pruniaux-Harnist, Philip, Janiak, Frédérique, Chézalviel-Guilbert
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 377(2)
In failing hearts, Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a12845b4a4ccba43a14d84bbb29c0fe6
https://pubmed.ncbi.nlm.nih.gov/33602875
https://pubmed.ncbi.nlm.nih.gov/33602875
Autor:
Jean-Pierre Valentin, Lyn Rosenbrier-Ribeiro, Stephen Jenkinson, Jean-Michel Guillon, Sonia Roberts, Duncan Armstrong, Friedemann Schmidt, Vivek J. Kadambi, Peri Ravikumar
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 93:7-14
Introduction In 2015, IQ DruSafe conducted a survey of its membership to identify industry practices related to in vitro off target pharmacological profiling of small molecules. Methods An anonymous survey of 20 questions was submitted to IQ-DruSafe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a766feee1296600d39053f3d781fb9a1
https://doi.org/10.1016/j.vascn.2018.07.001
https://doi.org/10.1016/j.vascn.2018.07.001