Histamine H(3) receptor-mediated signaling protects mice from cerebral malaria.

Autor: Walid Beghdadi, Adeline Porcherie, Bradley S Schneider, Séverine Morisset, David Dubayle, Roger Peronet, Michel Dy, Jacques Louis, Jean-Michel Arrang, Salaheddine Mécheri

Publikováno v: PLoS ONE, Vol 4, Iss 6, p e6004 (2009)

BACKGROUND:Histamine is a biogenic amine that has been shown to contribute to several pathological conditions, such as allergic conditions, experimental encephalomyelitis, and malaria. In humans, as well as in murine models of malaria, increased plas

Externí odkaz: https://doaj.org/article/55a53910eedb435cb98ac232fa28bd3b

BRET Analysis of GPCR Dimers in Neurons and Non-Neuronal Cells: Evidence for Inactive, Agonist, and Constitutive Conformations

Autor: Chayma El Khamlichi, Jean-Michel Arrang, L. Cobret, Séverine Morisset-Lopez

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, MDPI, 2021, 22 (19), pp.10638. ⟨10.3390/ijms221910638⟩
Volume 22
Issue 19
International Journal of Molecular Sciences, Vol 22, Iss 10638, p 10638 (2021)
International Journal of Molecular Sciences, 2021, 22 (19), pp.10638. ⟨10.3390/ijms221910638⟩

G-protein-coupled receptors (GPCRs) are dimeric proteins, but the functional consequences of the process are still debated. Active GPCR conformations are promoted either by agonists or constitutive activity. Inverse agonists decrease constitutive act

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f17c85c346365ad75229ffcc65c6a9d
https://hal.archives-ouvertes.fr/hal-03436322/document

Mechanistic characterization of S 38093, a novel inverse agonist at histamine H3 receptors

Autor: Jean-Marie Delbos, Esther Steidl, Tuulia Huhtala, Aurore Sors, Jean-Michel Arrang, Bruno Buisson, Patrick Casara, Outi Kontkanen, Lionel Bert, Valérie Audinot, Pierre Lestage, Olivier Nosjean, Anne-Marie Chollet, Fany Panayi, Dominique Favale

Publikováno v: European Journal of Pharmacology. 803:11-23

Histaminergic H3 inverse agonists, by stimulating central histamine release, represent attractive drug candidates to treat cognitive disorders. The present studies aimed to describe the mechanistic profile of S 38093 a novel H3 receptors inverse agon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e956afc9c4cbf151304775e3b54917d
https://doi.org/10.1016/j.ejphar.2017.03.013

Ciproxifan, a histamine H3-receptor antagonist / inverse agonist, modulates methamphetamine-induced sensitization in mice

Autor: Jean-Michel Arrang, Mouhammad Motawaj

Publikováno v: European Journal of Neuroscience. 33:1197-1204

The role of histamine neurons in schizophrenia and psychostimulant abuse remains unclear. Behavioural sensitization to psychostimulants is a cardinal feature of these disorders. Here, we have explored the ability of imetit and ciproxifan (CPX), a ref

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::29dfe9572bf02b9cb8aba1a8ee4e44cb
https://doi.org/10.1111/j.1460-9568.2011.07618.x

Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs

Autor: Aude Burban, Elisabeth Davenas, Mouhammad Motawaj, Raphaël Faucard, Jean-Michel Arrang, Florence Gbahou, S. Morisset

Publikováno v: Therapies. 65:415-422

Resume L’histamine exerce ses effets centraux en activant des recepteurs H 1 ,H 2 et H 3 . Le recepteur H 3 inhibe la liberation de l’histamine cerebrale. Ainsi, les agonistes inverses H 3 , en levant ce frein, augmentent l’activite des neurone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1bca94fee7d4536d785718e43c4d8c23
https://doi.org/10.2515/therapie/2010058