Zobrazeno 1 - 10
of 118
pro vyhledávání: '"Jean-Maurice Delabar"'
Autor:
Alizée Latour, Sacha Salameh, Christel Carbonne, Fabrice Daubigney, Jean-Louis Paul, Micheline Kergoat, Valérie Autier, Jean-Maurice Delabar, Bart De Geest, Nathalie Janel
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 2, Iss C, Pp 51-60 (2015)
Hyperhomocysteinemia results from hepatic metabolism dysfunction and is characterized by a high plasma homocysteine level, which is also an independent risk factor for cardiovascular disease. Elevated levels of homocysteine in plasma lead to hepatic
Externí odkaz:
https://doaj.org/article/52a5c705baee415583f8516c24f2a8e4
Autor:
Jean-Maurice Delabar, Alizée Latour, Christophe Noll, Marjorie Renon, Sacha Salameh, Jean-Louis Paul, Mariona Arbones, Jamileh Movassat, Nathalie Janel
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 1, Iss C, Pp 487-492 (2014)
Hyperhomocysteinemia due to cystathionine beta synthase deficiency confers diverse clinical manifestations. It is characterized by elevated plasma homocysteine levels, a common amino acid metabolized by remethylation to methionine or transsulfuration
Externí odkaz:
https://doaj.org/article/34adfcf08c424475b870291a74de140d
Autor:
Christophe Noll, Chris Planque, Clémentine Ripoll, Fayçal Guedj, Anna Diez, Véronique Ducros, Nicole Belin, Arnaud Duchon, Jean-Louis Paul, Anne Badel, Bénédicte de Freminville, Yann Grattau, Henri Bléhaut, Yann Herault, Nathalie Janel, Jean-Maurice Delabar
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7540 (2009)
BACKGROUND:Hyperhomocysteinemia, characterized by increased plasma homocysteine level, is associated with an increased risk of atherosclerosis. On the contrary, patients with Down syndrome appear to be protected from the development of atherosclerosi
Externí odkaz:
https://doaj.org/article/a94d4700836043619d53e9078d9d582e
Autor:
Jean-Maurice Delabar, Julien Lagarde, Marta Fructuoso, Ammara Mohammad, Michel Bottlaender, Eric Doran, Ira Lott, Frederic Schmitt, Elisabeth Head, Marie Sarazin, Marie-Claude Potier
Early markers are needed for more effective prevention of Alzheimer's disease. We previously showed that individuals with Alzheimer’s disease have decreased plasma DYRK1A levels compared to controls. We assessed DYRK1A in plasma of cognitively heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655e048fda4a2f61e2599a3a49cede4e
https://doi.org/10.21203/rs.3.rs-2370697/v1
https://doi.org/10.21203/rs.3.rs-2370697/v1
Autor:
Benoit Souchet, Fayçal Guedj, Ignasi Sahún, Arnaud Duchon, Fabrice Daubigney, Anne Badel, Yuchio Yanagawa, Maria Jose Barallobre, Mara Dierssen, Eugene Yu, Yann Herault, Mariona Arbones, Nathalie Janel, Nicole Créau, Jean Maurice Delabar
Publikováno v:
Neurobiology of Disease, Vol 69, Iss , Pp 65-75 (2014)
Cognitive deficits in Down syndrome (DS) have been linked to increased synaptic inhibition, leading to an imbalance of excitation/inhibition (E/I). Various mouse models and studies from human brains have implicated an HSA21 gene, the serine/threonine
Externí odkaz:
https://doaj.org/article/38eb53d8da744590b164b4cc0d3230c4
Autor:
Anna Vazquez, Eric D. Hamlett, Sébastien Malinge, Yann Herault, Frances K. Wiseman, Bradley T. Christian, Laura del Hoyo Soriano, Patricia A Shaw, Floriana Costanzo, John D. Crispino, Eugenio Barone, Jean Maurice Delabar, Renata Bartesaghi, Alain D. Dekker, Juan Fortea Ormaechea, Véronique Brault, Marzia Perluigi, Peter Paul De Deyn, Mara Dierssen, Elizabeth M. C. Fisher, Tarik F. Haydar, Lisa M. Jacola, Marie-Claude Potier, Stephanie L. Sherman, Anita Bhattacharyya, Leonard J Abbeduto, William C. Mobley, Maria Florencia Iulita, Andre Strydom, Maria Carmona-Iragui, María Martínez de Lagrán, Jorge Busciglio, Pablo Helguera, Anna J. Esbensen
Publikováno v:
Molecular Syndromology
Molecular Syndromology, Karger, 2021, 12 (4), pp.202-218. ⟨10.1159/000514437⟩
Molecular Syndromology, 1-17. KARGER
STARTPAGE=1;ENDPAGE=17;ISSN=1661-8769;TITLE=Molecular Syndromology
Molecular syndromology, vol 12, iss 4
Mol Syndromol
Molecular syndromology
Molecular Syndromology, Karger, 2021, 12 (4), pp.202-218. ⟨10.1159/000514437⟩
Molecular Syndromology, 1-17. KARGER
STARTPAGE=1;ENDPAGE=17;ISSN=1661-8769;TITLE=Molecular Syndromology
Molecular syndromology, vol 12, iss 4
Mol Syndromol
Molecular syndromology
International audience; Research focused on Down syndrome has increased in the last several years to advance understanding of the consequences of trisomy 21 (T21) on molecular and cellular processes and, ultimately, on individuals with Down syndrome.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c0ac5c585975417238d2ee740daa8a
https://hal.archives-ouvertes.fr/hal-03359724
https://hal.archives-ouvertes.fr/hal-03359724
Autor:
Aude-Marie Lepagnol-Bestel, Agnes Zvara, Gilles Maussion, Frédérique Quignon, Bedel Ngimbous, Nicolas Ramoz, Sandrine Imbeaud, Yann Loe-Mie, Karim Benihoud, Nicolas Agier, Paul A Salin, Ana Cardona, Suonavy Khung-Savatovsky, Pekka Kallunki, Jean-Maurice Delabar, Laszlo G Puskas, Hervé Delacroix, Lawrence Aggerbeck, Anne-Lise Delezoide, Olivier Delattre, Philip Gorwood, Jean-Marie Moalic, Michel Simonneau
Publikováno v:
Human Molecular Genetics. 31:2106-2107
Publikováno v:
Free Radical Biology and Medicine. 114:33-39
Down syndrome (DS), also known as trisomy 21, is the most common genetic cause of intellectual disability. It is also a model human disease for exploring consequences of gene dosage imbalance on complex phenotypes. Learning and memory impairments lin
Autor:
Yuchen Gu, Valérie Nalesso, Yuejin Yu, Julien Dairou, Yann Herault, Jean-Maurice Delabar, Nicole Créau, Fabrice Daubigney, Arnaud Duchon, Benoit Souchet, Claire Chevalier, Nathalie Janel
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9, pp.3914. ⟨10.1038/s41598-019-40328-9⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Scientific Reports, Nature Publishing Group, 2019, 9, pp.3914. ⟨10.1038/s41598-019-40328-9⟩
Down syndrome is a common genetic disorder caused by trisomy of chromosome 21. Brain development in affected foetuses might be improved through prenatal treatment. One potential target is DYRK1A, a multifunctional kinase encoded by chromosome 21 that
Autor:
Michel Mallat, Fabrice Daubigney, Catherine Colin, Sandrine Middendorp, Jean-Christophe Rain, Nadim Kassis, Valerie Hindie, M.L. Arbonés, Blandine Gausserès, Jean-Maurice Delabar, Jean-Louis Paul, Nathalie Janel, Yuchen Gu, Eugene Yu, Alizée Latour
Publikováno v:
Molecular Neurobiology
Molecular Neurobiology, Humana Press, 2019, 56 (2), pp.963-975. ⟨10.1007/s12035-018-1113-x⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Neurobiology, Humana Press, 2019, 56 (2), pp.963-975. ⟨10.1007/s12035-018-1113-x⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
International audience; Down syndrome is characterized by premature aging and dementia with neurological features that mimic those found in Alzheimer's disease. This pathology in Down syndrome could be related to inflammation, which plays a role in o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab1f26769338a1ae350f08e7f4bdceea
https://hal-cnrs.archives-ouvertes.fr/hal-03201563
https://hal-cnrs.archives-ouvertes.fr/hal-03201563