Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Jean-Marie Hornsperger"'
Publikováno v:
Journal of the American Chemical Society. 119:3201-3204
Mono- and polyhydroxytropolones are potent competitive inhibitors of inositol monophosphatase. Modeling studies indicate that this inhibition occurs most probably through a novel mode of action involving the chelation of the two magnesium ions in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::314d41f702328f89af829ffff816f016
https://doi.org/10.1021/ja9634278
https://doi.org/10.1021/ja9634278
Autor:
Daniel Schirlin, Jean-Noel Collard, J Dow, Jean-Georges Heydt, Sandrine Funes, Ezio Giacobini, Jean-Marie Hornsperger
Publikováno v:
Biochemical Society Transactions. 22:758-763
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf19edd48c57c83e0c83ca7011b2413
https://doi.org/10.1042/bst0220758
https://doi.org/10.1042/bst0220758
Publikováno v:
Pharmacology & Toxicology. 72:116-123
Pretreatment of mice with 5-fluoromethylornithine (5FMOrn), a selective inactivator of ornithine aminotransferase, diminishes the accumulation of ammonia in the brain after administration of ammonium acetate, and antagonizes ammonia-induced fatal ton
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea110c014662412459bea39d512e69c
https://doi.org/10.1111/j.1600-0773.1993.tb00301.x
https://doi.org/10.1111/j.1600-0773.1993.tb00301.x
Autor:
Daniel Schirlin, Jean-Marie Hornsperger, J Dow, Jean-Georges Heydt, Bertrand Dulery, Jean-Noel Collard
Publikováno v:
Alzheimer Disease ISBN: 9781461581512
Acetylcholinesterase inhibitors (AChEI) as palliative agents in the treatment of Alzheimer’s disease (AD) have been most widely studied so far. Novel compounds with higher lipophilicity, better selectivity and longer duration of inhibition are more
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34fc76fcbd3020099f68f650fdce39a5
https://doi.org/10.1007/978-1-4615-8149-9_23
https://doi.org/10.1007/978-1-4615-8149-9_23
Autor:
Philip R. Kastner, Robert J. Broersma, Donald P. Matthews, David A. Demeter, Herschel J. R. Weintraub, Jeffrey P. Whitten, Jean Marie Hornsperger, Roger D. McDermott, James R. McCarthy
Publikováno v:
Journal of medicinal chemistry. 33(7)
1-(2-Thienylalkyl)imidazole-2(3H)-thiones (5a-k) are competitive inhibitors of dopamine beta-hydroxylase (DBH) and demonstrate the utility of thiophene in the design of potent competitive inhibitors of this enzyme. The structure-activity relationship
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fbfd4a731e242b333e0b63636eb92e2
https://pubmed.ncbi.nlm.nih.gov/2362264
https://pubmed.ncbi.nlm.nih.gov/2362264
Publikováno v:
Neurochemical Research. 4:437-447
GABA added to rat hepatoma (HTC) cells in spinner culture at the time of induction of cell proliferation increased levels of ornithine decarboxylase (ODC) up to two- to threefold above that of control cells. The increases in ODC were also reflected b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fb127198c800f68ef65a4f222b27735
https://doi.org/10.1007/bf00964638
https://doi.org/10.1007/bf00964638
Publikováno v:
Biochemical Pharmacology. 33:327-330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22296505bc13d03b8da0212772772811
https://doi.org/10.1016/0006-2952(84)90493-3
https://doi.org/10.1016/0006-2952(84)90493-3
Publikováno v:
Journal of Cellular Physiology. 99:183-190
Exogenous diamines and polyamines added to rat hepatoma (HTC) cells in culture rapidly decrease ornithine decarboxylase (ODC) activity. Previous evidence has suggested that these amines set either at the level of blocking new enzyme synthesis or by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c8915504caa50a1871ef2f2b705882f7
https://doi.org/10.1002/jcp.1040990204
https://doi.org/10.1002/jcp.1040990204
Autor:
Creemer Lawrence C, Michael G. Palfreyman, Thomas M. Bargar, Jean Marie Hornsperger, Michel Jung, Joseph Wagner, James R. McCarthy, Robert J. Broersma
Publikováno v:
Journal of Medicinal Chemistry. 29:315-317
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b6cedde4187c47056bf0380495122a
https://doi.org/10.1021/jm00153a002
https://doi.org/10.1021/jm00153a002