Cyclin A2 mutagenesis analysis: a new insight into CDK activation and cellular localization requirements.

Autor: Nawal Bendris, Bénédicte Lemmers, Jean-Marie Blanchard, Nikola Arsic

Publikováno v: PLoS ONE, Vol 6, Iss 7, p e22879 (2011)

Cyclin A2 is essential at two critical points in the somatic cell cycle: during S phase, when it activates CDK2, and during the G2 to M transition when it activates CDK1. Based on the crystal structure of Cyclin A2 in association with CDKs, we genera

Externí odkaz: https://doaj.org/article/7f14ba0885ef46e8859cbfd94adca8f1

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

Autor: Jean-Marie Blanchard, Bénédicte Lemmers, Séverine Garnier, Valérie Pinet, Chloé Maurizy, Emilie Mamessier, Yuchen Guo, Monica Gabola, Florence Boissière-Michot, Michael Hahne, Quentin Da Costa, Pascal Finetti, Julie Bremond, Conception Paul, Ruizhi Tang, Rossano Lattanzio, Hulya Tulari, Céline Lemmers, Rania Azar, François Bertucci, Piotr Sicinski

To clarify the function of cyclin A2 in colon homeostasis and colorectal cancer (CRC) we generated mice deficient for cyclin A2 in colonic epithelial cells (CEC). Colons of those mice displayed architectural changes in the mucosa, and signs of inflam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d242d41512ffee7fe66bdd59f6d7f9eb
https://doi.org/10.1101/690404

Tissue-specific and SRSF1-dependent splicing of fibronectin, a matrix protein that controls host cell invasion

Autor: Isabel C. Lopez-Mejia, Jamal Tazi, Jean Marie Blanchard, Virginie Deleuze, Marie-Luce Vignais, Flavio Della Seta, Marion de Toledo, Christian Jorgensen, Cosette Rebouissou, Patrick Fafet

Publikováno v: Molecular Biology of the Cell
Molecular and Cellular Biology
Molecular and Cellular Biology, American Society for Microbiology, 2013, 24 (20), pp.3164-3176. ⟨10.1091/mbc.E13-03-0142)⟩
Molecular and Cellular Biology, 2013, 24 (20), pp.3164-3176. ⟨10.1091/mbc.E13-03-0142)⟩
Molecular Biology of the Cell, American Society for Cell Biology, 2013, 24 (20), pp.3164-76. ⟨10.1091/mbc.E13-03-0142⟩
Molecular Biology of the Cell, vol. 24, no. 20, pp. 3164-3176

Matching sets of human primary fibroblasts cocultured with placenta explants are used to compare tissue capacities to support trophoblast invasion. Substituting endometrium with dermis dramatically reduces EVCT interstitial invasion, a phenomenon rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2419973157fa208c3a0da61968e9c1b8
http://europepmc.org/articles/PMC3806663

Kizuna is a novel mitotic substrate for CDC25B phosphatase

Autor: Véronique Baldin, Olivier Coux, Francisca Mechali, Marion Peter, Jean-Marie Blanchard, Yann Thomas

Publikováno v: Cell Cycle
Cell Cycle, Taylor & Francis, 2015, 13 (24), pp.3867-3877. ⟨10.4161/15384101.2014.972882⟩

International audience; CDC25 dual-specificity phosphatases play a central role in cell cycle control through the activation of Cyclin-Dependent Kinases (CDKs). Expression during mitosis of a stabilized CDC25B mutant (CDC25B-DDA), which cannot intera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bf2d031b0aedd9757ae043406d6401
https://hal-cnrs.archives-ouvertes.fr/hal-02353356

Role for Brm in Cell Growth Control

Autor: Marjorie Coisy-Quivy, Jean-Christophe Dantonel, Olivier Disson, Jean-Marie Blanchard, Christian Muchardt, Virginie Roure

Publikováno v: Cancer Research. 66:5069-5076

Recently, we have shown implication of Brm, the catalytic subunit of the SWI/SNF chromatin remodeling complex, in repression of cyclin A expression in quiescent cells. Here, we have examined the fate of cells lacking Brm throughout the cycle. We find

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9799c7fb71e29adc82f6a02b46e08c46
https://doi.org/10.1158/0008-5472.can-05-0596