Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jean-Marie Billard"'
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 751 (2023)
The subtype 6 of the serotoninergic receptors (5-HT6Rs) is highly expressed in the hippocampus, and evidence indicates the beneficial effects of 5-HT6Rs blockade on short- and long-term memory in rodents. Nevertheless, the underlying functional mecha
Externí odkaz:
https://doaj.org/article/87a51119a28d40d29f7b3637bf9f7fa3
Autor:
Candice M. Roux, Pierre Lecouflet, Jean-Marie Billard, Elise Esneault, Marianne Leger, Pascale Schumann-Bard, Thomas Freret
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4304 (2023)
For almost half a century, acute hippocampal slice preparations have been widely used to investigate anti-amnesic (or promnesic) properties of drug candidates on long-term potentiation (LTP)—a cellular substrate that supports some forms of learning
Externí odkaz:
https://doaj.org/article/d9eafd80cb4d4f1f884208079249c8e5
Autor:
Jean-Marie Billard, Thomas Freret
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 15542 (2022)
Impaired activation of the N-methyl-D-aspartate subtype of glutamate receptors (NMDAR) by D-serine is linked to cognitive aging. Whether this deregulation may be used to initiate pharmacological strategies has yet to be considered. To this end, we pe
Externí odkaz:
https://doaj.org/article/4d121e7794c74b97bca904f03815ad6a
Autor:
Solenn Percelay, Jean-Marie Billard, Thomas Freret, Annie Andrieux, Michel Boulouard, Valentine Bouet
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5, p 2644 (2021)
For a better translation from treatment designs of schizophrenia to clinical efficiency, there is a crucial need to refine preclinical animal models. In order to consider the multifactorial nature of the disorder, a new mouse model associating three
Externí odkaz:
https://doaj.org/article/b92681563748421984518bf8e46afa0d
Autor:
Eva Ploux, Valentine Bouet, Inna Radzishevsky, Herman Wolosker, Thomas Freret, Jean-Marie Billard
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9447 (2020)
d-serine is the major co-agonist of N-methyl-D-aspartate receptors (NMDAR) at CA3/CA1 hippocampal synapses, the activation of which drives long-term potentiation (LTP). The use of mice with targeted deletion of the serine racemase (SR) enzyme has bee
Externí odkaz:
https://doaj.org/article/9f3e3b400fd7471d9e9cbecd25744db0
Autor:
Jean-Marie Billard
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The N-methyl-D-Aspartate glutamate receptors (NMDARs) are pivotal for the functional and morphological plasticity that are required in neuronal networks for efficient brain activities and notably for cognitive-related abilities. Because NMDARs are he
Externí odkaz:
https://doaj.org/article/119a53b387d34dbca7c1df87130b665f
Autor:
Marie Picot, Jean-Marie Billard, Carlos Dombret, Christelle Albac, Nida Karameh, Stéphanie Daumas, Hélène Hardin-Pouzet, Sakina Mhaouty-Kodja
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0148328 (2016)
We studied the role of testosterone, mediated by the androgen receptor (AR), in modulating temporal order memory for visual objects. For this purpose, we used male mice lacking AR specifically in the nervous system. Control and mutant males were gona
Externí odkaz:
https://doaj.org/article/bc26a2aabf214b059cf623b2ce71d509
Autor:
Glenn Dallérac, Caroline Perronnet, Carine Chagneau, Pascale Leblanc-Veyrac, Nathalie Samson-Desvignes, Elise Peltekian, Olivier Danos, Luis Garcia, Serge Laroche, Jean-Marie Billard, Cyrille Vaillend
Publikováno v:
Neurobiology of Disease, Vol 43, Iss 3, Pp 635-641 (2011)
Duchenne muscular dystrophy (DMD) is caused by the absence of dystrophin, a protein that fulfills important functions in both muscle and brain. The mdx mouse model of DMD, which also lacks dystrophin, shows a marked reduction in γ-aminobutyric acid
Externí odkaz:
https://doaj.org/article/ad0169baae5b421f99d7a1086b84a657
Publikováno v:
Neurobiology of Disease, Vol 17, Iss 1, Pp 10-20 (2004)
Duchenne muscular dystrophy (DMD) is associated with cognitive deficits that may result from dystrophin deficiency in neurons. However, in the dystrophin-deficient Dmdmdx mouse model of DMD, the nature of the memory impairment is not well characteris
Externí odkaz:
https://doaj.org/article/8639bbaf9e314cf1abcf97e86b355071
Autor:
Vinciane Régnier, Jean-Marie Billard, Sapna Gupta, Brigitte Potier, Stéphanie Woerner, Evelyne Paly, Aurélie Ledru, Sabrina David, Sabrina Luilier, Jean-Charles Bizot, Guido Vacano, Jan P Kraus, David Patterson, Warren D Kruger, Jean M Delabar, Jaqueline London
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29056 (2012)
The cystathionine β-synthase (CBS) gene, located on human chromosome 21q22.3, is a good candidate for playing a role in the Down Syndrome (DS) cognitive profile: it is overexpressed in the brain of individuals with DS, and it encodes a key enzyme of
Externí odkaz:
https://doaj.org/article/0b397ddeef404ea3802e5fffda370b15