Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Jean-Marc Neefs"'
Autor:
Xiaodi Yu, Jarek Juraszek, Lucy Rutten, Mark J G Bakkers, Sven Blokland, Jelle M Melchers, Niels J F van den Broek, Annemiek Y W Verwilligen, Pravien Abeywickrema, Johan Vingerhoets, Jean-Marc Neefs, Shah A Mohamed Bakhash, Pavitra Roychoudhury, Alex Greninger, Sujata Sharma, Johannes P M Langedijk
Publikováno v:
PLoS Pathogens, Vol 19, Iss 5, p e1011308 (2023)
The global spread of the SARS-CoV-2 virus has resulted in emergence of lineages which impact the effectiveness of immunotherapies and vaccines that are based on the early Wuhan isolate. All currently approved vaccines employ the spike protein S, as i
Externí odkaz:
https://doaj.org/article/0be9269368074520a2eea45098a564ec
Autor:
Dorien De Pooter, Ellen Van Gulck, Antony Chen, Claire F. Evans, Jean-Marc Neefs, Helen Horton, Daniel Boden
Publikováno v:
Vaccines, Vol 9, Iss 9, p 969 (2021)
Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cir
Externí odkaz:
https://doaj.org/article/47a9fd0208164534a56fcca1e29d82a0
Autor:
Joseline Ratnam, Barbara Zdrazil, Daniela Digles, Emiliano Cuadrado-Rodriguez, Jean-Marc Neefs, Hannah Tipney, Ronald Siebes, Andra Waagmeester, Glyn Bradley, Chau Han Chau, Lars Richter, Jose Brea, Chris T Evelo, Edgar Jacoby, Stefan Senger, Maria Isabel Loza, Gerhard F Ecker, Christine Chichester
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e115460 (2014)
Integration of open access, curated, high-quality information from multiple disciplines in the Life and Biomedical Sciences provides a holistic understanding of the domain. Additionally, the effective linking of diverse data sources can unearth hidde
Externí odkaz:
https://doaj.org/article/c1affc6cc2544706bec5f96b4cf53af7
Autor:
Sandrine Grosse, Abdellah Tahri, Pierre Raboisson, Yannis Houpis, Bart Stoops, Edgar Jacoby, Jean-Marc Neefs, Marnix Van Loock, Olivia Goethals, Peggy Geluykens, Jean-François Bonfanti, Tim H. M. Jonckers
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1879-1884
In continuation of our efforts of finding novel nucleoside inhibitors for the treatment of viral diseases, we initiated a discovery research program aimed at identifying novel nucleos(t)ide inhibitors for emerging diseases like Dengue and Chikungunya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a6a84c256df58b86b9b102ba666666
https://doi.org/10.1021/acsmedchemlett.2c00372
https://doi.org/10.1021/acsmedchemlett.2c00372
Autor:
Xiaodi Yu, Jarek Juraszek, Lucy Rutten, Mark J. G. Bakkers, Sven Blokland, Niels J.F. van den Broek, Annemiek Y.W. Verwilligen, Pravien Abeywickrema, Johan Vingerhoets, Jean-Marc Neefs, Shah A. Mohamed Bakhash, Pavitra Roychoudhury, Alex Greninger, Sujata Sharma, Johannes P. M. Langedijk
The SARS-CoV-2 spike protein is the target of neutralizing antibodies and the immunogen used in all currently approved vaccines. The global spread of the virus has resulted in emergence of lineages which are of concern for the effectiveness of immuno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d10aca51c91f341bb585e9502578521
https://doi.org/10.1101/2022.03.31.486561
https://doi.org/10.1101/2022.03.31.486561
Autor:
Jean-Marc Neefs, Pascale Dehertogh, Oliver Lenz, Jan Martin Berke, Karen Vergauwen, Ying Tan, Gengyan Wang, Thierry Verbinnen, Edgar Jacoby
Publikováno v:
Journal of Antimicrobial Chemotherapy. 75:2526-2534
Objectives To characterize antiviral activity of the capsid assembly modulator (CAM-N) JNJ-56136379 against HBV genotypes and variants carrying amino acid substitutions in the core protein. Methods Anti-HBV activity of JNJ-56136379 was investigated a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4984a46a2108bf4c4b822b74c6a4cb8
https://doi.org/10.1093/jac/dkaa179
https://doi.org/10.1093/jac/dkaa179
Autor:
Helen Horton, Dorien De Pooter, Daniel Boden, Antony K. Chen, Claire F. Evans, Jean-Marc Neefs, Ellen Van Gulck
Publikováno v:
Vaccines
Vaccines, Vol 9, Iss 969, p 969 (2021)
Volume 9
Issue 9
Vaccines, Vol 9, Iss 969, p 969 (2021)
Volume 9
Issue 9
Despite the availability of an effective prophylactic vaccine for more than 30 years, nearly 300 million people worldwide are chronically infected with the hepatitis B virus (HBV), leading to 1 death every 30 s mainly from viral hepatitis-related cir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::628f17a203ca3a8ade9195919ba1130e
http://europepmc.org/articles/PMC8471825
http://europepmc.org/articles/PMC8471825
Autor:
Laure Cougnaud, Hugo Ceulemans, Seong Joo Koo, Jelle Van de Waeter, Jean-Marc Neefs, Emmanuel Gustin, Jörg K. Wegner, Hinrich W. H. Göhlmann, Margino Steemans, Ilse Van den Wyngaert, Michael J. Cox, Soulaiman Benalla, Steffen Jaensch, Pieter J. Peeters, Yolanda T. Chong, Daan Seynaeve, Dmitry Malkov, Mart Bittremieux
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports
Scientific Reports
Phenomic profiles are high-dimensional sets of readouts that can comprehensively capture the biological impact of chemical and genetic perturbations in cellular assay systems. Phenomic profiling of compound libraries can be used for compound target i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ad9da8d1ef2e11a2c7e73ab2912140
Autor:
Sebastiaan L. Knijnenburg, Renger H. Jellema, Christine Kirkpatrick, Luiz Olavo Bonino da Silva Santos, Jean-Marc Neefs, Albert Mons, Martijn G. Kersloot, Gerbrand Ruiter, Wouter Franke, Herman van Vlijmen, Derk L. Arts, Bert Meerman, Scott J. Lusher, Arie Baak, Arne Waalkens, Rudi Verbeeck
Publikováno v:
Data Intelligence, 2(1-2), 276-284. MIT Press Journals
The industry sector is a very large producer and consumer of data, and many companies traditionally focused on production or manufacturing are now relying on the analysis of large amounts of data to develop new products and services. As many of the d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d7a64965909698e930529aef78e255
https://pure.amc.nl/en/publications/the-need-of-industry-to-go-fair(4d3962d4-a8a5-46e6-a134-5d6fca3bbb01).html
https://pure.amc.nl/en/publications/the-need-of-industry-to-go-fair(4d3962d4-a8a5-46e6-a134-5d6fca3bbb01).html
Autor:
Stefan Senger, Núria Queralt-Rosinach, L. Bartek, B. Roibás, Andrei Caracoti, N. I. Franklin, Daniela Digles, Jean-Marc Neefs, C. Herhaus, José Brea, Anna Gaulton, D. Marren, Chris T. Evelo, Ola Engkvist, Edgar Jacoby, Christine Chichester, Barbara Zdrazil, Gerhard F. Ecker, María Isabel Loza, Laura I. Furlong, H.W.T. (Herman) van Vlijmen
Publikováno v:
Medchemcomm, 7(6), 1237-1244. Royal Society of Chemistry
Med. Chem. Commun.
Recercat. Dipósit de la Recerca de Catalunya
instname
Med. Chem. Commun.
Recercat. Dipósit de la Recerca de Catalunya
instname
Phenotypic screening is in a renaissance phase and is expected by many academic and industry leaders to accelerate the discovery of new drugs for new biology. Given that phenotypic screening is per definition target agnostic, the emphasis of in silic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa604f5fc023ca090763d72f3802c484
https://cris.maastrichtuniversity.nl/en/publications/d9ac40ee-f19e-42c7-b930-a6408d398d5b
https://cris.maastrichtuniversity.nl/en/publications/d9ac40ee-f19e-42c7-b930-a6408d398d5b