miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response

Autor: Florence Abdallah, Elodie Henriet, Amandine Suet, Ali Arar, Rudy Clemençon, Jean-Marc Malinge, Gaël Lecellier, Patrick Baril, Chantal Pichon

Publikováno v: Cells, Vol 10, Iss 10, p 2547 (2021)

Psoriasis is a chronic inflammatory skin disease that is mediated by complex crosstalk between immune cells and keratinocytes (KCs). Emerging studies have showed a specific psoriatic microRNAs signature, in which miR-21 is one of the most upregulated

Externí odkaz: https://doaj.org/article/31402c5e25124348af629a1fc76c61d3

Cardiolipin-Based Lipopolyplex Platform for the Delivery of Diverse Nucleic Acids into Gram-Negative Bacteria

Autor: Tony Le Gall, Jean-Marc Malinge, Federico Perche, Tristan Montier, Chantal Pichon

Publikováno v: Pharmaceuticals
Pharmaceuticals, MDPI, 2019, 12 (2), pp.81. ⟨10.3390/ph12020081⟩
Pharmaceuticals, Vol 12, Iss 2, p 81 (2019)
Volume 12
Issue 2
Pharmaceuticals, 2019, 12 (2), pp.81. ⟨10.3390/ph12020081⟩

Antibiotic resistance is a growing public health concern. Because only a few novel classes of antibiotics have been developed in the last 40 years, such as the class of oxazolidinones, new antibacterial strategies are urgently needed [1]. Nucleic aci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52a84f20ead920db549dab282153b2fc
https://hal.archives-ouvertes.fr/hal-02172973

Production of DNA minicircles less than 250 base pairs through a novel concentrated DNA circularization assay enabling minicircle design with NF-κB inhibition activity

Autor: Patrick Midoux, Thomas Thibault, Patrick Baril, Jéril Degrouard, Jean-Marc Malinge, Chantal Pichon

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2017, 45 (5), pp.e26-e26. ⟨10.1093/nar/gkw1034⟩

International audience; Double-stranded DNA minicircles of less than 1000 bp in length have great interest in both fundamental research and therapeutic applications. Although minicircles have shown promising activity in gene therapy thanks to their g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f56f18be440d2e4bc0ae62d283e9123b
https://pubmed.ncbi.nlm.nih.gov/27899652

Cisplatin Is a DNA-Damaging Antitumour Compound Triggering Multifactorial Biochemical Responses in Cancer Cells: Importance of Apoptotic Pathways

Autor: Marie-Josèphe Giraud-Panis, Jean-Marc Malinge, Yuliya Sedletska

Publikováno v: Current Medicinal Chemistry-Anti-Cancer Agents. 5:251-265

cis-diamminedichloroplatinum(II) (cisplatin) is among the most active antitumour agent used in human chemotherapy. The purpose of this review is to give an insight in several molecular mechanisms that mediate the sensitivity of cancer cells to this d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fcf03226df0bf21ba1f140c1361ea0a
https://doi.org/10.2174/1568011053765967

RILES, a novel method for temporal analysis of the in vivo regulation of miRNA expression

Autor: Safia Ezzine, Benoit Barteau, Georges Vassaux, Chantal Pichon, Patrick Baril, Patrick Midoux, Jean-Marc Malinge, Bruno Pitard

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2013, epub ahead of print. ⟨10.1093/nar/gkt797⟩

International audience; : Novel methods are required to investigate the complexity of microRNA (miRNA) biology and particularly their dynamic regulation under physiopathological conditions. Herein, a novel plasmid-based RNAi-Inducible Luciferase Expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::230dd03f4a7144966fab353dfffd9a6d
https://pubmed.ncbi.nlm.nih.gov/24013565