Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Jean-Marc Goaillard"'
Autor:
Nicole Burkert, Shoumik Roy, Max Häusler, Dominik Wuttke, Sonja Müller, Johanna Wiemer, Helene Hollmann, Marvin Oldrati, Jorge Ramirez-Franco, Julia Benkert, Michael Fauler, Johanna Duda, Jean-Marc Goaillard, Christina Pötschke, Moritz Münchmeyer, Rosanna Parlato, Birgit Liss
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-26 (2023)
Abstract Here we present a deep learning-based image analysis platform (DLAP), tailored to autonomously quantify cell numbers, and fluorescence signals within cellular compartments, derived from RNAscope or immunohistochemistry. We utilised DLAP to a
Externí odkaz:
https://doaj.org/article/7e2313ece132485ba389be8ee8efcbe2
Autor:
Maya Belghazi, Cécile Iborra, Ophélie Toutendji, Manon Lasserre, Dominique Debanne, Jean-Marc Goaillard, Béatrice Marquèze-Pouey
Publikováno v:
Cells, Vol 13, Iss 11, p 944 (2024)
Pacemaking activity in substantia nigra dopaminergic neurons is generated by the coordinated activity of a variety of distinct somatodendritic voltage- and calcium-gated ion channels. We investigated whether these functional interactions could arise
Externí odkaz:
https://doaj.org/article/b52f952c8f1a4d0cb79584baf81e79b4
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 13 (2020)
Our general understanding of neuronal function is that dendrites receive information that is transmitted to the axon, where action potentials (APs) are initiated and propagated to eventually trigger neurotransmitter release at synaptic terminals. Eve
Externí odkaz:
https://doaj.org/article/72c0a9eed61f4383a1ae7a5757ce6e8e
Publikováno v:
J Neurosci
Journal of Neuroscience
Journal of Neuroscience, 2022, 42 (40), pp.7530-7546. ⟨10.1523/JNEUROSCI.2331-21.2022⟩
Journal of Neuroscience
Journal of Neuroscience, 2022, 42 (40), pp.7530-7546. ⟨10.1523/JNEUROSCI.2331-21.2022⟩
Action potential (AP) shape is a critical electrophysiological parameter, in particular because it strongly modulates neurotransmitter release. AP shape is also used to distinguish neuronal populations, as it greatly varies between neuronal types. Fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3a6f83a1d7f4e2c51ee4b427758382
https://europepmc.org/articles/PMC9546446/
https://europepmc.org/articles/PMC9546446/
Autor:
Jean-Marc Goaillard, Eve Marder
Publikováno v:
Annual Review of Neuroscience
International audience; The large number of ion channels found in all nervous systems poses fundamental questions concerning how the characteristic intrinsic properties of single neurons are determined by the specific subsets of channels they express
Publikováno v:
Entropy, Vol 21, Iss 9, p 869 (2019)
This paper presents methods that quantify the structure of statistical interactions within a given data set, and were applied in a previous article. It establishes new results on the k-multivariate mutual-information ( I k ) inspired by the topologic
Externí odkaz:
https://doaj.org/article/e55e50d7460c4767a5d8f2d4fee2468f
Autor:
Alexis Haddjeri-Hopkins, Marianne Amalric, Jorge Ramírez-Franco, Mónica Tapia, Fabien Tell, Jean-Marc Goaillard, Béatrice Marquèze-Pouey
Publikováno v:
eNeuro
eNeuro, Society for Neuroscience, 2021, 8, pp.ENEURO.0207-21.2021. ⟨10.1523/eneuro.0207-21.2021⟩
eNeuro, 2021, 8, pp.ENEURO.0207-21.2021. ⟨10.1523/eneuro.0207-21.2021⟩
eNeuro, Society for Neuroscience, 2021, 8, pp.ENEURO.0207-21.2021. ⟨10.1523/eneuro.0207-21.2021⟩
eNeuro, 2021, 8, pp.ENEURO.0207-21.2021. ⟨10.1523/eneuro.0207-21.2021⟩
Substantia nigra pars compacta (SNc) dopaminergic (DA) neurons display a peculiar electrical phenotype characterized in vitro by a spontaneous tonic regular activity (pacemaking activity), a broad action potential and a biphasic post-inhibitory respo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4e87c924c699824be581d80ca50442
https://hal.archives-ouvertes.fr/hal-03414818
https://hal.archives-ouvertes.fr/hal-03414818
Publikováno v:
eLife, Vol 3 (2014)
Neurons have complex electrophysiological properties, however, it is often difficult to determine which properties are the most relevant to neuronal function. By combining current-clamp measurements of electrophysiological properties with multi-varia
Externí odkaz:
https://doaj.org/article/0c8a55d024b54e2ba2e89d691a4ad14c
Autor:
Jean-Marc Goaillard, Martial A Dufour
Publikováno v:
eLife, Vol 3 (2014)
Drugs could treat neuropathic pain more effectively if they simultaneously targeted two or more types of ion channel.
Externí odkaz:
https://doaj.org/article/34a4aedd0e8940bd8106f971a6102f1d
Autor:
Béatrice Marquèze-Pouey, Sébastien Mailfert, Vincent Rouger, Jean-Marc Goaillard, Didier Marguet
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106803 (2014)
Signaling mediated by the epidermal growth factor (EGF) is crucial in tissue development, homeostasis and tumorigenesis. EGF is mitogenic at picomolar concentrations and is known to bind its receptor on high affinity binding sites depending of the ol
Externí odkaz:
https://doaj.org/article/c3b752c13da340788e8e8cca55ec04ac