Zobrazeno 1 - 10
of 316
pro vyhledávání: '"Jean-Marc Fritschy"'
Autor:
Paola Muttathukunnel, Michael Wälti, Mostafa A. Aboouf, Christina Köster-Hegmann, Tatjana Haenggi, Max Gassmann, Patrizia Pannzanelli, Jean-Marc Fritschy, Edith M. Schneider Gasser
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-22 (2023)
Abstract Myelination is a process tightly regulated by a variety of neurotrophic factors. Here, we show—by analyzing two transgenic mouse lines, one overexpressing EPO selectively in the brain Tg21(PDGFB-rhEPO) and another with targeted removal of
Externí odkaz:
https://doaj.org/article/f320bbf9181d4753a439410ef1ff3a6e
Autor:
Rochelle M. Hines, Hans Michael Maric, Dustin J. Hines, Amit Modgil, Patrizia Panzanelli, Yasuko Nakamura, Anna J. Nathanson, Alan Cross, Tarek Deeb, Nicholas J. Brandon, Paul Davies, Jean-Marc Fritschy, Hermann Schindelin, Stephen J. Moss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
The inhibitory synaptic protein collybistin (CB) and GABAAR-α subunits are thought to interact, but strength and specificity are unclear. Here the authors study the CB–α2 interaction and show that a mouse mutated in the CB-binding region of α2 d
Externí odkaz:
https://doaj.org/article/603d64a78c594cd6a9206450bd9f2e4e
Autor:
Himanish Ghosh, Luca Auguadri, Sereina Battaglia, Zahra Simone Thirouin, Khaled Zemoura, Simon Messner, Mario A. Acuña, Hendrik Wildner, Gonzalo E. Yévenes, Andrea Dieter, Hiroshi Kawasaki, Michael O. Hottiger, Hanns Ulrich Zeilhofer, Jean-Marc Fritschy, Shiva K. Tyagarajan
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
Gephyrin is a cytoplasmic scaffolding protein that selectively forms postsynaptic scaffolds at GABAergic and glycinergic synapses. Here the authors characterize regulatory mechanisms determining gephyrin scaffolding and GABAA receptor synaptic transm
Externí odkaz:
https://doaj.org/article/73ddc1c5e39d47848b61414b2085adaa
Autor:
Claire de Groot, Amalia Floriou-Servou, Yuan-Chen Tsai, Simon Früh, Manuela Kohler, Georgia Parkin, Cornelia Schwerdel, Giovanna Bosshard, Kai Kaila, Jean-Marc Fritschy, Shiva K Tyagarajan
Publikováno v:
PLoS Genetics, Vol 13, Iss 10, p e1007073 (2017)
In developing brain neuronal migration, dendrite outgrowth and dendritic spine outgrowth are controlled by Cdc42, a small GTPase of the Rho family, and its activators. Cdc42 function in promoting actin polymerization is crucial for glutamatergic syna
Externí odkaz:
https://doaj.org/article/7cb2b632fcce41a0b646288801f9b475
Autor:
Elif Engin, Kiersten S Smith, Yudong Gao, David Nagy, Rachel A Foster, Evgeny Tsvetkov, Ruth Keist, Florence Crestani, Jean-Marc Fritschy, Vadim Y Bolshakov, Mihaly Hajos, Scott A Heldt, Uwe Rudolph
Publikováno v:
eLife, Vol 5 (2016)
Recent findings indicate a high level of specialization at the level of microcircuits and cell populations within brain structures with regards to the control of fear and anxiety. The hippocampus, however, has been treated as a unitary structure in a
Externí odkaz:
https://doaj.org/article/36ba1eb9afb84233919d8ad50543f264
Publikováno v:
Neurobiology of Disease, Vol 44, Iss 2, Pp 174-184 (2011)
Intra-hippocampal injection of kainic acid (KA) in adult mice causes a focal lesion in the CA1 area and hilus of the dentate gyrus, as well as pronounced granule cell hypertrophy and dispersion. The lesion results in chronic focal seizures, with a tw
Externí odkaz:
https://doaj.org/article/e39e0bff0be445d78ffe57baa2589bc6
Publikováno v:
Neurobiology of Disease, Vol 31, Iss 2, Pp 169-187 (2008)
Epidemiological data indicate that 20–40% of the patients with epilepsy are refractory to treatment with antiepileptic drugs (AEDs). The mechanisms underlying pharmacoresistance in epilepsy are unclear, but several plausible hypotheses have emerged
Externí odkaz:
https://doaj.org/article/7188f4dd9b474565abdfe99916ed49a5
Autor:
Holger A. Volk, Dimitrula Arabadzisz, Jean-Marc Fritschy, Claudia Brandt, Kerstin Bethmann, Wolfgang Löscher
Publikováno v:
Neurobiology of Disease, Vol 21, Iss 3, Pp 633-646 (2006)
The disabling seizures associated with mesial temporal lobe epilepsy (TLE) are often resistant to antiepileptic drugs (AEDs). The biological basis of this refractoriness is unknown but may include alterations in AED targets in the epileptogenic brain
Externí odkaz:
https://doaj.org/article/a8b6b8a097ac47a29cf1503d29f4a163
Autor:
Thomas Bürli, Kristin Baer, Helge Ewers, Corinne Sidler, Christian Fuhrer, Jean-Marc Fritschy
Publikováno v:
PLoS ONE, Vol 5, Iss 7, p e11507 (2010)
Alpha7 neuronal nicotinic acetylcholine receptors (alpha7-nAChR) form Ca(2+)-permeable homopentameric channels modulating cortical network activity and cognitive processing. They are located pre- and postsynaptically and are highly abundant in hippoc
Externí odkaz:
https://doaj.org/article/71e2906c0ca742b38777e2a695eaf218
Autor:
Corinna Lappe-Siefke, Sven Loebrich, Wulf Hevers, Oliver B Waidmann, Michaela Schweizer, Susanne Fehr, Jean-Marc Fritschy, Ivan Dikic, Jens Eilers, Scott M Wilson, Matthias Kneussel
Publikováno v:
PLoS Genetics, Vol 5, Iss 9, p e1000631 (2009)
Ataxia represents a pathological coordination failure that often involves functional disturbances in cerebellar circuits. Purkinje cells (PCs) characterize the only output neurons of the cerebellar cortex and critically participate in regulating moto
Externí odkaz:
https://doaj.org/article/30f7a41463874c6fb94e8bfd41add2f8