Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Jean-Marc DeKeyser"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Nilotinib is a highly effective treatment for chronic myeloid leukemia but has been consistently associated with the development of nilotinib-induced arterial disease (NAD) in a subset of patients. To date, which cell types mediate this effe
Externí odkaz:
https://doaj.org/article/54bcecbe99f24cacb8e86b5ec53ec481
Autor:
Juan Lorenzo B. Pablo, Savannah L. Cornett, Lei A. Wang, Sooyeon Jo, Tobias Brünger, Nikita Budnik, Mudra Hegde, Jean-Marc DeKeyser, Christopher H. Thompson, John G. Doench, Dennis Lal, Alfred L. George, Jr., Jen Q. Pan
Publikováno v:
Cell Reports, Vol 42, Iss 6, Pp 112563- (2023)
Summary: It is challenging to apply traditional mutational scanning to voltage-gated sodium channels (NaVs) and functionally annotate the large number of coding variants in these genes. Using a cytosine base editor and a pooled viability assay, we sc
Externí odkaz:
https://doaj.org/article/a26ee4757b7c41068a33d54562302016
Autor:
Tracy S. Gertler, Suraj Cherian, Jean-Marc DeKeyser, Jennifer A. Kearney, Alfred L. George, Jr
Publikováno v:
Neurobiology of Disease, Vol 168, Iss , Pp 105713- (2022)
KCNT1 encodes the sodium-activated potassium channel KNa1.1, expressed preferentially in the frontal cortex, hippocampus, cerebellum, and brainstem. Pathogenic missense variants in KCNT1 are associated with intractable epilepsy, namely epilepsy of in
Externí odkaz:
https://doaj.org/article/a281ef78d17b40329578f8004652cca5
Autor:
Scott K. Adney, John J. Millichap, Jean‐Marc DeKeyser, Tatiana Abramova, Christopher H. Thompson, Alfred L. George Jr
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 9, Pp 1488-1501 (2020)
Abstract Objective We identified a novel de novo SCN2A variant (M1879T) associated with infantile‐onset epilepsy that responded dramatically to sodium channel blocker antiepileptic drugs. We analyzed the functional and pharmacological consequences
Externí odkaz:
https://doaj.org/article/00621ebc305d48fe9c645cc9868c7015
Autor:
Hui-Hsuan Kuo, Xiaozhi Gao, Jean-Marc DeKeyser, K. Ashley Fetterman, Emily A. Pinheiro, Carly J. Weddle, Hananeh Fonoudi, Michael V. Orman, Marisol Romero-Tejeda, Mariam Jouni, Malorie Blancard, Tarek Magdy, Conrad L. Epting, Alfred L. George, Jr., Paul W. Burridge
Publikováno v:
Stem Cell Reports, Vol 14, Iss 2, Pp 256-270 (2020)
Summary: Human induced pluripotent stem cell (hiPSC) culture has become routine, yet the cost of pluripotent cell media, frequent medium changes, and the reproducibility of differentiation have remained restrictive. Here, we describe the formulation
Externí odkaz:
https://doaj.org/article/02ff6b71bbf049cbb92ceee86f3339ee
Autor:
Marisol Romero-Tejeda, Hananeh Fonoudi, Carly J. Weddle, Jean-Marc DeKeyser, Brian Lenny, K. Ashley Fetterman, Tarek Magdy, Yadav Sapkota, Conrad Epting, Paul W. Burridge
Publikováno v:
bioRxiv
The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts. However, this process has been less successful in human cells, thus limiting th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a25decd27ef77b8bb8f66c2ed17d3e
https://doi.org/10.1101/2023.03.14.532629
https://doi.org/10.1101/2023.03.14.532629
Autor:
Marisol Romero Tejeda, Hananeh Fonoudi, Carly J Weddle, Jean-Marc DeKeyser, Conrad L Epting, Paul W Burridge
Publikováno v:
Circulation Research. 131
The reprogramming of somatic cells to a spontaneously contracting cardiomyocyte-like state using defined transcription factors has proven successful in mouse fibroblasts, but has been less successful with human cells, limiting the potential clinical
Autor:
Tatiana Abramova, Christopher H. Thompson, Alfred L. George, John Millichap, Jean Marc DeKeyser, Scott K. Adney
Publikováno v:
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology, Vol 7, Iss 9, Pp 1488-1501 (2020)
Annals of Clinical and Translational Neurology, Vol 7, Iss 9, Pp 1488-1501 (2020)
Objective We identified a novel de novo SCN2A variant (M1879T) associated with infantile‐onset epilepsy that responded dramatically to sodium channel blocker antiepileptic drugs. We analyzed the functional and pharmacological consequences of this v
Publikováno v:
Neurobiology of disease. 168
KCNT1 encodes the sodium-activated potassium channel K
Autor:
Carlos G, Vanoye, Christopher H, Thompson, Reshma R, Desai, Jean-Marc, DeKeyser, Liqi, Chen, Laura J, Rasmussen-Torvik, Leah J, Welty, Alfred L, George
Publikováno v:
Methods in enzymology. 654
Patch clamp recording enabled a revolution in cellular electrophysiology, and is useful for evaluating the functional consequences of ion channel gene mutations or variants associated with human disorders called channelopathies. However, due to massi