The RSNA QIBA Profile for Amyloid PET as an Imaging Biomarker for Cerebral Amyloid Quantification

Autor: Anne M. Smith, Nancy A. Obuchowski, Norman L. Foster, Gregory Klein, P. David Mozley, Adriaan A. Lammertsma, Richard L. Wahl, John J. Sunderland, Jean-Luc Vanderheyden, Tammie L.S. Benzinger, Paul E. Kinahan, Dean F. Wong, Eric S. Perlman, Satoshi Minoshima, Dawn Matthews

Publikováno v: Smith, A M, Obuchowski, N A, Foster, N L, Klein, G, Mozley, P D, Lammertsma, A A, Wahl, R L, Sunderland, J J, Vanderheyden, J-L, Benzinger, T L S, Kinahan, P E, Wong, D F, Perlman, E S, Minoshima, S & Matthews, D 2023, ' The RSNA QIBA Profile for Amyloid PET as an Imaging Biomarker for Cerebral Amyloid Quantification ', Journal of Nuclear Medicine, vol. 64, no. 2, pp. 294-303 . https://doi.org/10.2967/jnumed.122.264031

A standardized approach to acquiring amyloid PET images increases their value as disease and drug response biomarkers. Most 18F PET amyloid brain scans often are assessed only visually (per regulatory labels), with a binary decision indicating the pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7c4c51bc8b9671a0a13312bae46cd4
https://pubmed.ncbi.nlm.nih.gov/36137760

Synthesis, biodistribution and effects of farnesyltransferase inhibitor therapy on tumour uptake in mice of 99mTc labelled epidermal growth factor

Autor: Ruth Oltenfreiter, Jean-Luc Vanderheyden, Guido Slegers, Ingrid Burvenich, Otto C. Boerman, Bart Cornelissen, Veerle Kersemans, Christophe Vandewiele

Publikováno v: Nuclear Medicine Communications, 26, 147-53
Nuclear Medicine Communications, 26, 2, pp. 147-53

Contains fulltext : 48444.pdf (Publisher’s version ) (Closed access) OBJECTIVE: The goal of this study was to develop a 99mTc labelled human epidermal growth factor (hEGF) for the in-vivo prediction of cancer cell response to farnesyltransferase in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf298c6121a52d3b6c9dce3e87208632
https://ora.ox.ac.uk/objects/uuid:de98adcb-c323-4b41-b05c-43af0de1300a

Broad and Specific Caspase Inhibitor-Induced Acute Repression of Apoptosis in Atherosclerotic Lesions Evaluated by Radiolabeled Annexin A5 Imaging

Autor: Jun Zhou, Masayoshi Sarai, Nathan D. Wong, Shinichiro Fujimoto, Navneet Narula, Sudhir Gupta, Dagmar Hartung, Frank D. Kolodgie, Jagat Narula, Chris P. M. Reutelingsperger, Jean-Luc Vanderheyden, Leonard Hofstra, Artiom Petrov, Renu Virmani, Satoshi Isobe

Publikováno v: Journal of the American College of Cardiology. 50:2305-2312

ObjectivesThe purpose of this study was to evaluate the role of caspase inhibitors on acute resolution of apoptosis in atherosclerotic lesions as evaluated by imaging with annexin A5.BackgroundExtensive apoptosis of macrophages has been reported at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a4dda029dddcd680accaa2e31d37b82
https://doi.org/10.1016/j.jacc.2007.08.044

99mTc-Annexin-V uptake in a rat model of variable ischemic severity and reperfusion time

Autor: Takahiro Higuchi, Jean-Luc Vanderheyden, Muramori A, Ichiro Matsunari, H. William Strauss, Kenichi Nakajima, Jonathan F. Tait, Atsuhiro Kawashima, Junichi Taki

Publikováno v: Circulation Journal. 71(7):1141-1146

金沢大学医学部附属病院核医学診療科
Background: To determine whether mild to moderate ischemia that is not severe enough to induce myocardial infarction will cause myocardial cell damage or apoptosis, the 99mTc-Annexin-V (Tc-A) u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496a917d71adbd213157a2c507524290
http://hdl.handle.net/2297/6863

99mTc-HYNIC-annexin V SPECT imaging of acute stroke and its response to neuroprotective therapy with anti-Fas ligand antibody

Autor: Maya A. Koike, Allan M. Green, Jean-Luc Vanderheyden, Judy E. Kalinyak, Michael L. Goris, Francis G. Blankenberg, Midori A. Yenari, Danye Cheng, Liping Liu, David C. Tong

Publikováno v: European Journal of Nuclear Medicine and Molecular Imaging. 33:566-574

The first aim of the study was to determine whether 99mTc-HYNIC-annexin V, a marker of cellular stress and apoptosis, can detect ischemic injury in patients with acute stroke. Secondly, we wished to test radiolabeled annexin’s ability to monitor th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef5921ee0726ad470c9596b760f96b42
https://doi.org/10.1007/s00259-005-0046-6