Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Jean-Luc Haesslein"'
Autor:
Jean Paul Vevert, Christine Pierre, Anne Marie Periers, Isabelle Baholet, Alain Iltis, Jean Luc Haesslein, Jean Khider, Michel Fortin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:1487-1490
The design, synthesis, and in vitro biological activity of a series of 2-carboxy quinolone antagonists selective for the endothelin A receptor are presented. Introduction of a second acid group in position 3 of the quinolone ring increases dramatical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d4a52a7ebc5fecfdccfd492649e309
https://doi.org/10.1016/s0960-894x(00)00264-x
https://doi.org/10.1016/s0960-894x(00)00264-x
Autor:
Michel Klich, Yannick Benedetti, Periers Anne-Marie, Alain Iltis, Didier Ferroud, Patrick Laurin, Jean-Luc Haesslein, Sylvette Lachaud, Guillaume L’Hermite, Branislav Musicki
Publikováno v:
Tetrahedron Letters. 41:867-871
The stereoselective synthesis of 5-monosubstituted and 5,5-dialkylsubstituted noviose derivatives has been achieved starting from l -arabinose. These noviose derivatives could be used as useful building blocks in probing structure–activity relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbff1f220d335f75abc0f1d829befc9a
https://doi.org/10.1016/s0040-4039(99)02177-2
https://doi.org/10.1016/s0040-4039(99)02177-2
Autor:
Periers Anne-Marie, Alain Bonnefoy, Didier Ferroud, Michel Klich, Patrice Lassaigne, Pascale Mauvais, Branislav Musicki, Jean-Luc Haesslein, Patrick Laurin, Claudine Dupuis-Hamelin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 10:161-165
The synthesis and biological profile in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3' of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7759aba47e7200be6016886f62b04427
https://doi.org/10.1016/s0960-894x(99)00654-x
https://doi.org/10.1016/s0960-894x(99)00654-x
Autor:
Michel Klich, Guillaume L’Hermite, Yannick Benedetti, Periers Anne-Marie, Jean-Luc Haesslein, Sylvette Lachaud, Branislav Musicki, Didier Ferroud, Patrick Laurin, Alain Iltis
Publikováno v:
ChemInform. 31
The stereoselective synthesis of 5-monosubstituted and 5,5-dialkylsubstituted noviose derivatives has been achieved starting from l -arabinose. These noviose derivatives could be used as useful building blocks in probing structure–activity relation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c7d468405a7d857e1cf889bedd339f7
https://doi.org/10.1002/chin.200016221
https://doi.org/10.1002/chin.200016221
Autor:
Periers Anne-Marie, Didier Ferroud, Pascale Mauvais, Branislav Musicki, Jean-Luc Haesslein, Michel Klich, Patrice Lassaigne, Alain Bonnefoy, Claudine Dupuis-Hamelin, Patrick Laurin
Publikováno v:
ChemInform. 31
The synthesis and biological profile in vitro of a series of coumarin inhibitors of gyrase B bearing a N-propargyloxycarbamate at C-3' of noviose is presented. Replacement of the 5-methylpyrrole-2-carboxylate of coumarin drugs with an N-propargyloxyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba45abcd17b4442b25eb83db84ff6470
https://doi.org/10.1002/chin.200021226
https://doi.org/10.1002/chin.200021226
Autor:
Anne-Marie Tremblet, Danielle Massardier, Jean-Luc Haesslein, Peter Francis Hunt, Alain Jouanen
Publikováno v:
Journal of Neuroscience Methods. 36:27-32
N- Methyl- d -aspartate (NMDA)-induced release of [ 3 H]GABA from mouse striatal neurons in primary culture has been evaluated as a screening method for demonstrating the functional activity of potential NMDA antagonists with respect to a cellular re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da2ca9a7f46907330e12d62857ba7811
https://doi.org/10.1016/0165-0270(91)90134-l
https://doi.org/10.1016/0165-0270(91)90134-l
Publikováno v:
Progress in cell cycle research. 5
Life-threatening fungal infections are becoming more frequent and involve a greater variety of strains, many of which are drug-resistant. Both public research organisations and the pharmaceutical industry are committed to the development of new drugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f1c24e3e68136ab935fadb223726236d
https://pubmed.ncbi.nlm.nih.gov/14593703
https://pubmed.ncbi.nlm.nih.gov/14593703
Autor:
Marie-Thérèse Bocquel, Florence Bordon-Pallier, Anne-Marie Girard, Jean-Luc Haesslein, Jacques Biton, Paul Ferrari, Nathalie Jullian, Nicolas Bouquin
Publikováno v:
Biochimica et biophysica acta. 1697(1-2)
There is today a blatant need for new antifungal agents, because of the recent increase in life-threatening infections involving an ever-greater number of fungal strains. Fungi make extensive use of kinases in the regulation of essential processes, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90a376d0a9faa352774648b93adf8ff7
https://pubmed.ncbi.nlm.nih.gov/15023362
https://pubmed.ncbi.nlm.nih.gov/15023362
Autor:
Jean-Luc Haesslein, Nathalie Jullian
Publikováno v:
Current topics in medicinal chemistry. 2(9)
Protein kinases (Ser/Thr and Tyr) play a key role in signal transduction pathways. It has been shown that deregulation of the Cdk activity is linked to cell proliferation and cancer. Inhibition of cyclin-dependent kinases (Cdks) is an important targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d898982e5fe9fba35a0873e53ebb7b13
https://pubmed.ncbi.nlm.nih.gov/12171570
https://pubmed.ncbi.nlm.nih.gov/12171570
Autor:
Isabelle Baholet, Jean-Paul Vevert, Jean-Luc Haesslein, Anne Marie Peries, Christine Pierre, Alain Iltis, Jean Khider, Michel Fortin
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f445121a03d674d2d1a3439390b4c23
https://doi.org/10.1002/chin.200042126
https://doi.org/10.1002/chin.200042126