Clostridium perfringens epsilon toxin targets granule cells in the mouse cerebellum and stimulates glutamate release.

Autor: Etienne Lonchamp, Jean-Luc Dupont, Laetitia Wioland, Raphaël Courjaret, Corinne Mbebi-Liegeois, Emmanuel Jover, Frédéric Doussau, Michel R Popoff, Jean-Louis Bossu, Jean de Barry, Bernard Poulain

Publikováno v: PLoS ONE, Vol 5, Iss 9, p e13046 (2010)

Epsilon toxin (ET) produced by C. perfringens types B and D is a highly potent pore-forming toxin. ET-intoxicated animals express severe neurological disorders that are thought to result from the formation of vasogenic brain edemas and indirect neuro

Externí odkaz: https://doaj.org/article/d8915b8ca71749f7a48be7d3dd3969ce

Organotypic cultures of cerebellar slices as a model to investigate demyelinating disorders

Autor: Bernard Poulain, Dorine Neel, Jean Luc Dupont, Frédéric Doussau, Jean Louis Bossu, Aline Schneider

Publikováno v: Expert Opinion on Drug Discovery
Expert Opinion on Drug Discovery, Informa Healthcare, 2017, 12 (10), pp.1011-1022. ⟨10.1080/17460441.2017.1356285⟩

Demyelinating disorders, characterized by a chronic or episodic destruction of the myelin sheath, are a leading cause of neurological disability in young adults in western countries. Studying the complex mechanisms involved in axon myelination, demye

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d0db3f53935f72f67e018ecf8387e47
https://doi.org/10.1080/17460441.2017.1356285

Clusters of cerebellar Purkinje cells control their afferent climbing fiber discharge

Autor: Clément Léna, Daniela Popa, Fekrije Selimi, Vanessa Gautheron, Nicolas Guyon, Stéphane Dieudonné, Jean-Christophe Cassel, Frédéric Doussau, Joseph Chaumont, Guillaume P. Dugué, Jean-Luc Dupont, Bernard Poulain, Aline Stephan, Antoine M. Valera, Philippe Isope, Païkan Marcaggi, Michel Barrot, Sophie Reibel-Foisset

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2013, 110 (40), pp.16223-16228. ⟨10.1073/pnas.1302310110⟩

Climbing fibers, the projections from the inferior olive to the cerebellar cortex, carry sensorimotor error and clock signals that trigger motor learning by controlling cerebellar Purkinje cell synaptic plasticity and discharge. Purkinje cells target

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7074f4286299e7e183624ef36822e611
https://doi.org/10.1073/pnas.1302310110

Deletion of Cav2.1(α1A) subunit of Ca2+-channels impairs synaptic GABA and glutamate release in the mouse cerebellar cortex in cultured slices

Autor: Jean-Luc Dupont, Jean-Louis Bossu, Bernard Poulain, Etienne Lonchamp, Frédéric Doussau, Hee-Sup Shin

Publikováno v: European Journal of Neuroscience. 30:2293-2307

Deletion of both alleles of the P/Q-type Ca(2+)-channel Ca(v)2.1(alpha(1A)) subunit gene in mouse leads to severe ataxia and early death. Using cerebellar slices obtained from 10 to 15 postnatal days mice and cultured for at least 3 weeks in vitro, w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f99b647cf43d80143b344501fb28d1b
https://doi.org/10.1111/j.1460-9568.2009.07023.x

Glia-induced neuronal differentiation by transcriptional regulation

Autor: Katja Nieweg, Renaud Thiebaut, Leon J. Schurgers, Christoph Moehle, Frank W. Pfrieger, Gerd Schmitz, Christian Göritz, Luc-Henri Tessier, Jean-Luc Dupont, Isabelle Buard

Publikováno v: Glia
Glia, Wiley, 2007, 55 (11), pp.1108-1122. ⟨10.1002/glia.20531⟩

There is increasing evidence that different phases of brain development depend on neuron-glia interactions including postnatal key events like synaptogenesis. To address how glial cells influence synapse development, we analyzed whether and how glia-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0923e058168bb2c8455da5e453b6f879
https://doi.org/10.1002/glia.20531