SILVI, an open-source pipeline for T-cell epitope selection.

Autor: Joana Pissarra, Franck Dorkeld, Etienne Loire, Vincent Bonhomme, Denis Sereno, Jean-Loup Lemesre, Philippe Holzmuller

Publikováno v: PLoS ONE, Vol 17, Iss 9, p e0273494 (2022)

High-throughput screening of available genomic data and identification of potential antigenic candidates have promoted the development of epitope-based vaccines and therapeutics. Several immunoinformatic tools are available to predict potential epito

Externí odkaz: https://doaj.org/article/29edef4b35914481aad396ab3fd8621e

The separation of trypanosomes from blood by anion exchange chromatography: From Sheila Lanham's discovery 50 years ago to a gold standard for sleeping sickness diagnosis.

Autor: Veerle Lejon, Philippe Büscher, Romaric Nzoumbou-Boko, Géraldine Bossard, Vincent Jamonneau, Bruno Bucheton, Philippe Truc, Jean-Loup Lemesre, Philippe Solano, Philippe Vincendeau

Publikováno v: PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007051 (2019)

Human African trypanosomiasis (HAT), or sleeping sickness, is a neglected tropical disease that is fatal if untreated, caused by Trypanosoma brucei gambiense and T. brucei rhodesiense. In its 2012 roadmap, WHO targeted HAT for elimination as a public

Externí odkaz: https://doaj.org/article/4f65cf3559484cbb8a6c6639ca82ea6c

Trypanosomatid Infections: How Do Parasites and Their Excreted–Secreted Factors Modulate the Inducible Metabolism of l-Arginine in Macrophages?

Autor: Philippe Holzmuller, Anne Geiger, Romaric Nzoumbou-Boko, Joana Pissarra, Sarra Hamrouni, Valérie Rodrigues, Frédéric-Antoine Dauchy, Jean-Loup Lemesre, Philippe Vincendeau, Rachel Bras-Gonçalves

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Mononuclear phagocytes (monocytes, dendritic cells, and macrophages) are among the first host cells to face intra- and extracellular protozoan parasites such as trypanosomatids, and significant expansion of macrophages has been observed in infected h

Externí odkaz: https://doaj.org/article/2e953df2a2e748c7bae80f6bec7d9878

In vitro evaluation of a soluble Leishmania promastigote surface antigen as a potential vaccine candidate against human leishmaniasis.

Autor: Rym Chamakh-Ayari, Rachel Bras-Gonçalves, Narges Bahi-Jaber, Elodie Petitdidier, Wafa Markikou-Ouni, Karim Aoun, Javier Moreno, Eugenia Carrillo, Poonam Salotra, Himanshu Kaushal, Narender Singh Negi, Jorge Arevalo, Francesca Falconi-Agapito, Angela Privat, Maria Cruz, Julie Pagniez, Gérard-Marie Papierok, Faten Bel Haj Rhouma, Pilar Torres, Jean-Loup Lemesre, Mehdi Chenik, Amel Meddeb-Garnaoui

Publikováno v: PLoS ONE, Vol 9, Iss 5, p e92708 (2014)

PSA (Promastigote Surface Antigen) belongs to a family of membrane-bound and secreted proteins present in several Leishmania (L.) species. PSA is recognized by human Th1 cells and provides a high degree of protection in vaccinated mice. We evaluated

Externí odkaz: https://doaj.org/article/43367cf9df764d0c9cb36074fe25178c

Proteomic analysis of the promastigote secretome of seven Leishmania species

Autor: Joana Pissarra, Philippe Holzmuller, Julie Pagniez, Oana Vigy, Rachel Bras-Gonçalves, Jean-Loup Lemesre, Martial Séveno, Elodie Petitdidier

Publikováno v: Journal of Proteome Research
Journal of Proteome Research, American Chemical Society, 2022, 21 (1), pp.30-48. ⟨10.1021/acs.jproteome.1c00244⟩
Journal of Proteome Research, American Chemical Society, 2021, ⟨10.1021/acs.jproteome.1c00244⟩

International audience; Leishmaniasis is one of the most impactful parasitic diseases worldwide, endangering the lives of 1 billion people every year. There are 20 different species of Leishmania able to infect humans, causing cutaneous (CL), viscera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e867a68a8788a39e54eb7df0c8fba094
http://agritrop.cirad.fr/601843/