Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Jean-Louis Peglion"'
Autor:
Elsa P. Bianchini, Jean Louis Peglion, Allan De Carvalho, Stéphane Pautus, Alain Rupin, Mouad Alami, Gilles Ferry, Natacha Bonneau, Jean Daniel Brion, Pierre Champy, Philippe Gloanec, Daniel A. Lawrence, Guillaume Bernadat, Frédéric Adam, Delphine Borgel, Abdallah Hamze
Publikováno v:
Scientific Reports
Plasminogen activator inhibitor-1 (PAI-1) is the main inhibitor of the tissue type and urokinase type plasminogen activators. High levels of PAI-1 are correlated with an increased risk of thrombotic events and several other pathologies. Despite sever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a495195c0d7e983159a24d79527219
http://europepmc.org/articles/PMC5120274
http://europepmc.org/articles/PMC5120274
Publikováno v:
European Neuropsychopharmacology. 19:887-897
Though serotonergic mechanisms modulate circadian rhythms, roles of individual serotonin (5-HT) receptors remain uncertain since data are lacking for antagonists. Herein, both the 5-HT(5A) receptor antagonist, A843277 (10 mg/kg), and the 5-HT(1B) ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f78842cbdcf1e1ede09e9dfc85b0153
https://doi.org/10.1016/j.euroneuro.2009.06.011
https://doi.org/10.1016/j.euroneuro.2009.06.011
Publikováno v:
Tetrahedron. 64:5703-5710
Octalactin B was synthesized from the commercially available methyl-3-butenoate and isobutyraldehyde, using enantioselective allyl- and crotyltitanations to control the stereogenic centers at C3, C4, C7, C8, and C13. Moreover, the two other key-step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c67a0d85877c3b453ea051b366337fc
https://doi.org/10.1016/j.tet.2008.04.026
https://doi.org/10.1016/j.tet.2008.04.026
Autor:
Francis Cogé, Pascale Chomarat, Guillaumin Jp, Stephane Bedut, Brunel-Jacquemin C, Jean-Louis Peglion, Piffard L, Nicole Villeneuve, Catherine Thollon, Jean A. Boutin, Jean-Paul Vilaine
Publikováno v:
British Journal of Pharmacology. 150:37-46
Background and purpose: Ivabradine, a specific and use-dependent If inhibitor, exerts anti-ischaemic activity purely by reducing heart rate. The aim of this work was to characterize its effect on the predominant HCN channel isoform expressed in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a112514f16c2f806606d22613c045ca7
https://doi.org/10.1038/sj.bjp.0706940
https://doi.org/10.1038/sj.bjp.0706940
Autor:
Roger D. Porsolt, J M Rivet, Pierre Lestage, Anne Dekeyne, Robert Jaffard, Jean Louis Peglion, Alain P. Gobert, Elisabeth Mocaer, Benjamin Di Cara, Mirjana Carli, Sylvain Roux, Alfredo Meneses, Millan Mark
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 311:190-203
These studies examined the influence of the selective 5-hydroxytryptamine (serotonin) (5-HT)(1A) receptor partial agonist S15535 [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine] upon cholinergic transmission and cognitive function in rodents. In the ab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a911f061b1fdbda76e36681bcb8ddf83
https://doi.org/10.1124/jpet.104.069625
https://doi.org/10.1124/jpet.104.069625
Autor:
Jean-Michel Rivet, Françoise Lejeune, Alain P. Gobert, Clotilde Mannoury la Cour, Jean-Louis Peglion, Millan Mark, Didier Cussac, Adrian Newman-Tancredi
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:903-920
S32504 [(+)-trans-3,4,4a,5,6,10b-hexahydro-9-carbamoyl-4-propyl-2H-naphth[1,2-b]-1,4-oxazine] displayed marked affinity for cloned, human (h)D(3) receptors (pK(i), 8.1) at which, in total G-protein ([(35)S]GTPgammaS binding, guanosine-5'-O-(3-[(35)S]
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::663cae6557a7b662a1c7527d199612a6
https://doi.org/10.1124/jpet.103.062398
https://doi.org/10.1124/jpet.103.062398
Publikováno v:
Journal of Cardiovascular Pharmacology. 42:688-696
The effects of ivabradine, a novel heart rate-reducing agent that inhibits the cardiac pacemaker current If, were compared with those of the beta-adrenergic blocker propranolol, in a model of exercise-induced regional myocardial ischemia in pigs. Fiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f849254d38d9660c671ed43de2b4fc6d
https://doi.org/10.1097/00005344-200311000-00016
https://doi.org/10.1097/00005344-200311000-00016
Publikováno v:
European Heart Journal Supplements. 5:G26-G35
Procoralan (S 16257-2) is a selective inhibitor of the pacemaker If current. It reduces in vitro the spontaneous beating rate of the sinus node by slowing the diastolic depolarization slope of the action potential. It induces in vivo a selective and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9bf5becff76e87b6329e93967e6538bf
https://doi.org/10.1016/s1520-765x(03)90005-8
https://doi.org/10.1016/s1520-765x(03)90005-8
Autor:
Patrick Genissel, Anne Dekeyne, Adrian Newman-Tancredi, Bertrand Goument, Marc Bertrand, Millan Mark, Valérie Charlot, Jean-Louis Peglion, Christian Nisole, Hélène Giraud, Nicole Despaux
Publikováno v:
Journal of Medicinal Chemistry. 45:165-176
S 15535 (1) displays a distinctive profile of agonist and antagonist (weak partial agonist) activity at pre- and postsynaptic 5-HT(1A) receptors, respectively. It has proven to be active in several models predictive of anxiolytic, antidepressant, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90cce17930fabc2876ec44906a8bc3b9
https://doi.org/10.1021/jm010975+
https://doi.org/10.1021/jm010975+
Publikováno v:
Tetrahedron Letters. 39:2965-2968
The synthesis of spiro[quinoline-2,4′-piperidines] by using a radical or a Heck reaction, as the key step, is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cd1e8dca3a9b8c985cff744c6bc6f06
https://doi.org/10.1016/s0040-4039(98)00389-x
https://doi.org/10.1016/s0040-4039(98)00389-x