Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Jean-Louis Junien"'
Autor:
Michael P. Cooreman, Javed Butler, Robert P. Giugliano, Faiez Zannad, Lucile Dzen, Philippe Huot-Marchand, Martine Baudin, Daniel R. Beard, Jean-Louis Junien, Pierre Broqua, Manal F. Abdelmalek, Sven M. Francque
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Lanifibranor, a pan-PPAR agonist, improves liver histology in patients with metabolic dysfunction-associated steatohepatitis (MASH), who have poor cardiometabolic health (CMH) and cardiovascular events as major mortality cause. NATIVE trial
Externí odkaz:
https://doaj.org/article/a8349f7dd9df4b16ac7569db5e4e8c59
Autor:
Eugeni Entchev, Ingrid Jantzen, Philippe Masson, Stephanie Bocart, Bruno Bournique, Jean-Michel Luccarini, Andre Bouchot, Olivier Lacombe, Jean-Louis Junien, Pierre Broqua, Mireille Tallandier
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0233032 (2020)
Mucopolysaccharidoses are a class of lysosomal storage diseases, characterized by enzymatic deficiency in the degradation of specific glycosaminoglycans (GAG). Pathological accumulation of excess GAG leads to multiple clinical symptoms with systemic
Externí odkaz:
https://doaj.org/article/18aaeaa92fd84ae2983028dab3ec1275
Autor:
David Abraham, Rachel K. Hoyles, Irena Konstantinova, Emma Derrett-Smith, Kristina E N Clark, Jean Louis Junien, Xu Shiwen, Voon H Ong, Christopher P. Denton, Pierre Broqua, Olivier Lacombe
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-13 (2021)
Arthritis Research & Therapy
Arthritis Research & Therapy
Background The TβRII∆k-fib transgenic (TG) mouse model of scleroderma replicates key fibrotic and vasculopathic complications of systemic sclerosis through fibroblast-directed upregulation of TGFβ signalling. We have examined peroxisome prolifera
Autor:
Jaime Bosch, Claude Robert, Jean-Louis Junien, Guillaume Wettstein, Pierre Broqua, Jordi Gracia-Sancho, Anabel Fernández-Iglesias, Martí Ortega-Ribera, Peio Aristu-Zabalza, María Andrés-Rozas, Zoe Boyer-Diaz
Publikováno v:
Boyer-Diaz, Zoe; Aristu-Zabalza, Peio; Andrés-Rozas, María; Robert, Claude; Ortega-Ribera, Martí; Fernández-Iglesias, Anabel; Broqua, Pierre; Junien, Jean-Louis; Wettstein, Guillaume; Bosch, Jaime; Gracia-Sancho, Jordi (2021). Pan-PPAR agonist lanifibranor improves portal hypertension and hepatic fibrosis in experimental advanced chronic liver disease. Journal of hepatology, 74(5), pp. 1188-1199. Elsevier 10.1016/j.jhep.2020.11.045
Background & aims In advanced chronic liver disease (ACLD), deregulated hepatic necroinflammatory processes play a key role in the development of liver microvascular dysfunction, fibrogenesis, and increased hepatic vascular tone, resulting in progres
Autor:
Michael Cooreman, Sven Francque, Martine Baudin, Philippe Huot-Marchand, Lucile Dzen, Jean-Louis Junien, Pierre Broqua, Manal Abdelmalek
Publikováno v:
Journal of Hepatology. 77:S722-S723
Autor:
Michael Cooreman, Manal Abdelmalek, Martine Baudin, Philippe Huot-Marchand, Lucile Dzen, Céline Fournier, Jean-Louis Junien, Pierre Broqua, Sven Francque
Publikováno v:
Journal of Hepatology. 77:S722
Autor:
Jerome Boursier, Hugo Herve, Clémence M Canivet, Marine Roux, Pierre Broqua, Michael Cooreman, Jean-Louis Junien, Jean Louis Abitbol, Philippe Huot-Marchand, Lucile Dzen, Sanjaykanumar Patel
Publikováno v:
Journal of Hepatology. 77:S715
Autor:
Bruno Bournique, Eugeni Entchev, Stephanie Bocart, Ingrid Jantzen, Jean-Louis Junien, Jean-Michel Luccarini, Olivier Lacombe, Philippe Masson, Mireille Tallandier, Pierre Broqua, André Bouchot
Publikováno v:
PLoS ONE
PLoS ONE, Public Library of Science, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
PLoS ONE, Vol 15, Iss 5, p e0233032 (2020)
PLoS ONE, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
PLoS ONE, Public Library of Science, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
PLoS ONE, Vol 15, Iss 5, p e0233032 (2020)
PLoS ONE, 2020, 15 (5), pp.e0233032. ⟨10.1371/journal.pone.0233032⟩
International audience; Mucopolysaccharidoses are a class of lysosomal storage diseases, characterized by enzymatic deficiency in the degradation of specific glycosaminoglycans (GAG). Pathological accumulation of excess GAG leads to multiple clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f57cf8f55479c409e7f909dd02436ef8
https://www.hal.inserm.fr/inserm-02894692
https://www.hal.inserm.fr/inserm-02894692
Akademický článek
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Autor:
Jean-Michel Luccarini, Christophe Guignabert, Irena Konstantinova, Sonia Pezet, Jérémy Sadoine, Jean-Louis Junien, Pierre Broqua, Yannick Allanore, Anne Cauvet, Thomas Guilbert, Ly Tu, Jérôme Avouac
Publikováno v:
Annals of the Rheumatic Diseases. 76:1931-1940
ObjectiveTo evaluate the antifibrotic effects of the pan-peroxisome proliferator-activated receptor (PPAR) agonist IVA337 in preclinical mouse models of pulmonary fibrosis and related pulmonary hypertension (PH).MethodsIVA337 has been evaluated in th