Výsledky vyhledávání - "Jean-Louis Dasseux"

Akademický článek

HDL and CER-001 Inverse-Dose Dependent Inhibition of Atherosclerotic Plaque Formation in apoE-/- Mice: Evidence of ABCA1 Down-Regulation.

Autor: Claudine Tardy, Marine Goffinet, Nadia Boubekeur, Guy Cholez, Rose Ackermann, Gavin Sy, Constance Keyserling, Narendra Lalwani, John F Paolini, Jean-Louis Dasseux, Ronald Barbaras, Rudi Baron

Publikováno v: PLoS ONE, Vol 10, Iss 9, p e0137584 (2015)

CER-001 is a novel engineered HDL-mimetic comprised of recombinant human apoA-I and charged phospholipids that was designed to mimic the beneficial properties of nascent pre-ß HDL. In this study, we have evaluated the dose-dependent regulation of AB

Externí odkaz: https://doaj.org/article/e16d79e6193243fba26822127534738d

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No benefit of HDL mimetic CER-001 on carotid atherosclerosis in patients with genetically determined very low HDL levels

Autor: Jean-Louis Dasseux, Yannick Kaiser, Erik S.G. Stroes, Daniel Gaudet, Aart J. Nederveen, Constance Keyserling, Robert A. Hegele, Jacques Genest, Kang H. Zheng, Raul D. Santos, Olivier S. Descamps, Jan Westerink, Casper C. van Olden, Paul N. Hopkins, Eran Leitersdorf, Hein J. Verberne

Publikováno v: Atherosclerosis, 311, 13-19. Elsevier Ireland Ltd

Background and aims Infusion of high-density lipoprotein (HDL) mimetics failed to induce regression of atherosclerosis in recent randomized clinical trials. However, patients in these previous trials had normal levels of HDL-cholesterol, which potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad0bb4c333e54dc4e6e32fb2d652dfc
https://doi.org/10.1016/j.atherosclerosis.2020.08.004

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Lipoproteins for therapeutic delivery: recent advances and future opportunities

Autor: Andras G. Lacko, Sangram Raut, Jean Louis Dasseux, Linda Mooberry, Nirupama Sabnis

Publikováno v: Therapeutic Delivery. 9:257-268

The physiological role(s) of mammalian plasma lipoproteins is to transport hydrophobic molecules (primarily cholesterol and triacylglycerols) to their respective destinations. Lipoproteins have also been studied as drug-delivery agents due to their a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8190fdc3f98770854aae51b640b96855
https://doi.org/10.4155/tde-2017-0122

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Effect of serial infusions of CER-001, a pre-β High-density lipoprotein mimetic, on coronary atherosclerosis in patients following acute coronary syndromes in the CER-001 atherosclerosis regression acute coronary syndrome trial: A randomized clinical trial

Autor: Kausik K. Ray, Julie Butters, A. Janssan, Jean Louis Dasseux, Liddy Griffith, Daniel J. Scherer, Connie Keyserling, Susan Kim, Stephen G. Worthley, Steven E. Nissen, Giuseppe Di Giovanni, Jordan Andrews, Gregory G. Schwartz, Béla Merkely, Anthony D. Pisaniello, John J.P. Kastelein, Stephen J. Nicholls, Peter J. Psaltis

Publikováno v: JAMA cardiology, 3(9), 815-822. American Medical Association

Importance CER-001 is a negatively charged, engineered pre-β high-density lipoprotein (HDL) mimetic containing apolipoprotein A-I and sphingomyelin. Preliminary studies demonstrated favorable effects of CER-001 on cholesterol efflux and vascular inf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::508f0a2924bee17bf21873e46022e954
https://doi.org/10.1001/jamacardio.2018.2121

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Regression of coronary atherosclerosis with infusions of the high-density lipoprotein mimetic CER-001 in patients with more extensive plaque burden

Autor: Julie Butters, Constance Keyserling, Stephen J. Nicholls, Jessica Fendler, Yu Kataoka, John F. Paolini, N. Schwarz, Jordan Andrews, Rishi Puri, My Ngan Duong, Jean Louis Dasseux, Tracy Nguyen

Publikováno v: Cardiovascular Diagnosis and Therapy. 7:252-263

Background: CER-001 is an engineered pre-beta high-density lipoprotein (HDL) mimetic, which rapidly mobilizes cholesterol. Infusion of CER-001 3 mg/kg exhibited a potentially favorable effect on plaque burden in the CHI-SQUARE (Can HDL Infusions Sign

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a02740a2e2dc66d97aa418c793f2cb2
https://doi.org/10.21037/cdt.2017.02.01

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Re‐polarization of tumor‐associated macrophages via reconstituted high‐density lipoprotein nanoparticles

Autor: Sangram Raut, Akpedje Serena Dossou, Nirupama Sabnis, Andras G. Lacko, Jean‐Louis Dasseux

Publikováno v: The FASEB Journal. 33

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8dde3a25690da6a3581821a233ebe50a
https://doi.org/10.1096/fasebj.2019.33.1_supplement.494.1

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Effect of open-label infusion of an apoA-I-containing particle (CER-001) on RCT and artery wall thickness in patients with FHA

Autor: Raul D. Santos, Theo H. van Dijk, Erik S.G. Stroes, Loek P. Smits, Fleur M. van der Valk, John F. Paolini, Geesje M. Dallinga-van Thie, Aart J. Nederveen, Ruud S. Kootte, Albert K. Groen, Willem J. M. Mulder, G. Kees Hovingh, John J.P. Kastelein, Constance Keyserling, Ronald Barbaras, Jean-Louis Dasseux

Publikováno v: Journal of Lipid Research, 56(3), 703-712. AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
Journal of lipid research, 56(3), 703-712. American Society for Biochemistry and Molecular Biology Inc.
Journal of Lipid Research, Vol 56, Iss 3, Pp 703-712 (2015)

Reverse cholesterol transport (RCT) contributes to the anti-atherogenic effects of HDL. Patients with the orphan disease, familial hypoalphalipoproteinemia (FHA), are characterized by decreased tissue cholesterol removal and an increased atherogenic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69939042d1b1972246343ab07733bd59
https://doi.org/10.1194/jlr.m055665

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