New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation.

Autor: Jeungjin Kim, Baihe Chen, Jean-Louis Bru, Eric Huynh, Mahsa Momen, Dana W Aswad

Publikováno v: PLoS ONE, Vol 13, Iss 6, p e0198266 (2018)

Protein L-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the pcmt1 gene, catalyzes repair of abnormal L-isoaspartyl linkages in age-damaged proteins. Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an

Externí odkaz: https://doaj.org/article/b23ade4a1bcd4298ab786242dd987e51

Roadmap on emerging concepts in the physical biology of bacterial biofilms:from surface sensing to community formation

Autor: Nikhil S. Malvankar, Kyle A. Floyd, Knut Drescher, Jing Yan, Yves V. Brun, Alexandre Persat, Haoran Xu, Jaime de Anda, Jörn Dunkel, Jyot D. Antani, Yilin Wu, Masanori Toyofuku, George A. O'Toole, Lori A. Zacharoff, Yutaka Yawata, Allon I. Hochbaum, Marco Kühn, Nobuhiko Nomura, Mohamed Y. El-Naggar, Roman Stocker, Gregory B. Whitfield, Sibel Ebru Yalcin, Ramin Golestanian, Francesco Carrara, Howard A. Stone, Calvin K. Lee, Pushkar P. Lele, Gerard C. L. Wong, Fitnat H. Yildiz, Ned S. Wingreen, Albert Siryaporn, Mauricio D. Rojas-Andrade, Jacinta C. Conrad, Shuai Yang, Jing Chen, Jean Louis Bru, Beiyan Nan, Bonnie L. Bassler, Fan Jin, Leo Eberl, Nina Molin Høyland-Kroghsbo, William C. Schmidt

Publikováno v: Wong, G C L, Antani, J D, Lele, P, Nan, B, Kühn, M J, Persat, A, Bru, J-L, Høyland-Kroghsbo, N M, Siryaporn, A, Conrad, J, Carrara, F, Yawata, Y, Stocker, R, Brun, Y, Whitfield, G, Lee, C, de Anda, J, Schmidt, W C, Golestanian, R, O'Toole, G A, Floyd, K, Yildiz, F, Yang, S, Jin, F, Toyofuku, M, Eberl, L, Nobuhiko, N, Zacharoff, L, El-Naggar, M Y, Yalcin, S E, Malvankar, N, Rojas-Andrade, M D, Hochbaum, A, Yan, J, Stone, H A, Wingreen, N S, Bassler, B, Wu, Y, Xu, H, Drescher, K & Dunkel, J 2021, ' Roadmap on emerging concepts in the physical biology of bacterial biofilms : from surface sensing to community formation ', Physical Biology, vol. 18, no. 5 . https://doi.org/10.1088/1478-3975/abdc0e
Physical Biology, 18 (5)

Bacterial biofilms are communities of bacteria that exist as aggregates that can adhere to surfaces or be free-standing. This complex, social mode of cellular organization is fundamental to the physiology of microbes and often exhibits surprising beh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7fd0cf989701aca36eb0ec3785ae132
https://curis.ku.dk/ws/files/273580050/Wong_2021_Phys._Biol._18_051501.pdf

PQS Produced by the Pseudomonas aeruginosa Stress Response Repels Swarms Away from Bacteriophage and Antibiotics

Autor: Brandon Rawson, Jean-Louis Bru, Albert Siryaporn, Katrine Whiteson, Nina Molin Høyland-Kroghsbo, Calvin Trinh

Publikováno v: J Bacteriol
Journal of bacteriology, vol 201, iss 23

We investigate the effect of bacteriophage infection and antibiotic treatment on the coordination of swarming, a collective form of flagellum- and pilus-mediated motility in bacteria. We show that phage infection of the opportunistic bacterial pathog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc4c2f4ab782e885875f1754d218bcf7
https://doi.org/10.1128/jb.00383-19

New findings on SNP variants of human protein L-isoaspartyl methyltransferase that affect catalytic activity, thermal stability, and aggregation

Autor: Jean-Louis Bru, Baihe Chen, Eric Huynh, Dana W. Aswad, Jeungjin Kim, Mahsa Momen

Publikováno v: PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198266 (2018)

Protein L-isoaspartyl methyltransferase (PIMT/PCMT1), a product of the pcmt1 gene, catalyzes repair of abnormal L-isoaspartyl linkages in age-damaged proteins. Pcmt1 knockout mice exhibit a profound neuropathology and die 30-60 days postnatal from an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddf453e479254fbdcf306a5f69da35b
https://pubmed.ncbi.nlm.nih.gov/29856810

Polymorphic Variants of Human Protein L-Isoaspartyl Methyltransferase Affect Catalytic Activity, Aggregation, and Thermal Stability.

Autor: Charity Juang¹, Baihe Chen¹, Jean-Louis Bru¹, Nguyen, Katherine¹, Huynh, Eric¹, Momen, Mahsa¹, Jeungjin Kim¹, Aswad, Dana W.¹ dwaswad@uci.edu

Publikováno v: Journal of Biological Chemistry. 3/3/2017, Vol. 292 Issue 9, p3656-3665. 10p.