Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Jean-Louis Bessereau"'
Autor:
Teresa M.L. Cramer, Berangere Pinan-Lucarre, Anna Cavaccini, Angeliki Damilou, Yuan-Chen Tsai, Musadiq A. Bhat, Patrizia Panzanelli, Nicolas Rama, Patrick Mehlen, Dietmar Benke, Theofanis Karayannis, Jean-Louis Bessereau, Shiva K. Tyagarajan
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112947- (2023)
Summary: The molecular code that controls synapse formation and maintenance in vivo has remained quite sparse. Here, we identify that the secreted protein Adamtsl3 functions as critical hippocampal synapse organizer acting through the transmembrane r
Externí odkaz:
https://doaj.org/article/5d6008f4088e4776b7758e3496236210
Publikováno v:
Cells, Vol 12, Iss 17, p 2201 (2023)
Pharmacological adaptation is a common phenomenon observed during prolonged drug exposure and often leads to drug resistance. Understanding the cellular events involved in adaptation could provide new strategies to circumvent this resistance issue. W
Externí odkaz:
https://doaj.org/article/b6272240080e4216b2bcd2df02d366cd
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
The appearance of synapses was a crucial step in the creation of the variety of nervous systems that are found in the animal kingdom. With increased complexity of the organisms came a greater number of synaptic proteins. In this review we describe sy
Externí odkaz:
https://doaj.org/article/99f0ee9b78e24b179e78374dd21bd21c
Autor:
Xin Zhou, Marine Gueydan, Maelle Jospin, Tingting Ji, Aurore Valfort, Bérangère Pinan-Lucarré, Jean-Louis Bessereau
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The netrin receptor UNC-40/DCC is required to recruit GABAAR at neuromuscular junctions in C. elegans. Here, the authors show that UNC-40/DCC assembles an intracellular synaptic scaffold, regulating the content of GABAAR and inhibitory neurotransmiss
Externí odkaz:
https://doaj.org/article/7d1978beeef44807a09ef637fddb90d3
Autor:
Inés González-Calvo, Keerthana Iyer, Mélanie Carquin, Anouar Khayachi, Fernando A Giuliani, Séverine M Sigoillot, Jean Vincent, Martial Séveno, Maxime Veleanu, Sylvana Tahraoui, Mélanie Albert, Oana Vigy, Célia Bosso-Lefèvre, Yann Nadjar, Andréa Dumoulin, Antoine Triller, Jean-Louis Bessereau, Laure Rondi-Reig, Philippe Isope, Fekrije Selimi
Publikováno v:
eLife, Vol 10 (2021)
Fine control of protein stoichiometry at synapses underlies brain function and plasticity. How proteostasis is controlled independently for each type of synaptic protein in a synapse-specific and activity-dependent manner remains unclear. Here, we sh
Externí odkaz:
https://doaj.org/article/01bd3175794d47878ad8b245d0150a1d
Autor:
Xin Zhou, Jean-Louis Bessereau
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Inhibitory synapses represent a minority of the total chemical synapses in the mammalian brain, yet proper tuning of inhibition is fundamental to shape neuronal network properties. The neurotransmitter γ-aminobutyric acid (GABA) mediates rapid synap
Externí odkaz:
https://doaj.org/article/6bca273eae7a4991a31574e056fb013a
Autor:
Manuela D'Alessandro, Magali Richard, Christian Stigloher, Vincent Gache, Thomas Boulin, Janet E Richmond, Jean-Louis Bessereau
Publikováno v:
eLife, Vol 7 (2018)
The assembly of neurotransmitter receptors in the endoplasmic reticulum limits the number of receptors delivered to the plasma membrane, ultimately controlling neurotransmitter sensitivity and synaptic transfer function. In a forward genetic screen c
Externí odkaz:
https://doaj.org/article/c3a5106665694437baa8b4ca7e6306d4
Autor:
Maelle Jospin, Yingchuan B Qi, Tamara M Stawicki, Thomas Boulin, Kim R Schuske, H Robert Horvitz, Jean-Louis Bessereau, Erik M Jorgensen, Yishi Jin
Publikováno v:
PLoS Biology, Vol 7, Iss 12, p e1000265 (2009)
In the nematode Caenorhabditis elegans, cholinergic motor neurons stimulate muscle contraction as well as activate GABAergic motor neurons that inhibit contraction of the contralateral muscles. Here, we describe the composition of an ionotropic acety
Externí odkaz:
https://doaj.org/article/26dc32d117ba4ba4a0a111376661c2af
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
Biophysical properties of ligand-gated receptors can be profoundly modified by auxiliary subunits or by the lipid microenvironment of the membrane. Hence, it is sometimes challenging to relate the properties of receptors reconstituted in heterologous
Publikováno v:
Genetics. 223
The nematode Caenorhabditis elegans is a research model organism particularly suited to the mechanistic understanding of synapse genesis in the nervous system. Armed with powerful genetics, knowledge of complete connectomics, and modern genomics, stu