Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jean-Loic Le Net"'
Publikováno v:
Toxicologic Pathology. 39:410-413
Amylase-resistant, periodic acid-Schiff (PAS)–positive inclusions were identified in the skeletal muscle of four of twenty-four purpose-bred beagle dogs from a routine toxicology study. Affected myofibers contained amorphous material filling up to
Autor:
Nicolas Daguès, Stephan Chevalier, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Cécile Sobry, Pierre Comby
Publikováno v:
Toxicology Letters. 179:15-22
Phosphodiesterase 4 (PDE4) inhibitors are potential therapeutic agents but vascular injury and perivascular inflammation occurs frequently during preclinical toxicology testing of these drugs. The lesions induced by PDE4 inhibitors have been describe
Autor:
Jean-Loic Le Net, Pierre Bonnet, Daniel Antier, Véronique Eder, Mathieu Gautier, Gilles Hanton
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 293:H1046-H1052
We aimed to investigate the toxicity of carbon monoxide (CO) in rats with right ventricle (RV) remodeling induced by hypoxic pulmonary hypertension (PHT). A group of Wistar rats was exposed to 3-wk hypobaric hypoxia (H). A second group was exposed to
Autor:
Gilles Hanton, Jeremy R. Everett, Jean-Pierre Provost, Jeremy K. Nicholson, T. Andrew Clayton, Huiru Tang, Claude Charuel, John C. Lindon, Ivan K. S. Yap, Jean-Loic Le Net
Publikováno v:
Journal of Proteome Research. 5:2675-2684
The time-related metabolic events in rat liver, plasma, and urine following hepatotoxic insult with allyl formate (75 mg/kg) were studied using a combination of high-resolution liquid state and magic angle spinning (MAS) nuclear magnetic resonance (N
Autor:
Henrik Antti, Jeremy K. Nicholson, Gilles Hanton, T. Andrew Clayton, Jean-Pierre Provost, Rosalind Walley, Jeremy R. Everett, Jean-Loic Le Net, Olivier Cloarec, David Baker, John C. Lindon, Claude Charuel
Publikováno v:
Nature. 440:1073-1077
There is a clear case for drug treatments to be selected according to the characteristics of an individual patient, in order to improve efficacy and reduce the number and severity of adverse drug reactions1,2. However, such personalization of drug tr
Autor:
Jean-Loic Le Net, Jeremy D. Gale, K H Banner, Aleksandar Popovic, Christophe Cattaneo, David M. Collins
Publikováno v:
British Journal of Pharmacology. 143:590-598
1 A novel animal model of spontaneous colonic inflammation, the multiple drug-resistant (mdr1) a(-/-) mouse, was identified by Panwala and colleagues in 1998. The aim of our study was to further characterise this model, specifically by measuring cyto
Autor:
Eric Dumas de la Roque, Jean-Loic Le Net, Pierre Bonnet, Sébastien Bonnet, Julien Boissiere, Mathieu Gautier, Véronique Eder
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H1023-H1028
The purpose of this study was to evaluate the reversibility of right ventricular (RV) remodelling after pulmonary artery hypertension (PAHT) secondary to 3 wk of hypobaric hypoxia. A group of 10 adult male Wistar rats were studied and were the follow
Autor:
Claude Charuel, Gilles Hanton, Jean-Loic Le Net, Jean-Pierre Provost, Jeremy K. Nicholson, Jeremy R. Everett, T. Andrew Clayton, John C. Lindon
Publikováno v:
Archives of Toxicology. 77:208-217
As part of a wider metabonomic investigation into the early detection and discrimination of site-specific hepatotoxicity, male Sprague-Dawley rats were dosed with the model hepatotoxins allyl formate, ethionine and alpha-naphthylisothiocyanate (ANIT)
Autor:
Gavin A. Whitlock, Stephen C. Phillips, Anthony Harrison, Florian Wakenhut, Nicola Regan, Nick Clarke, M. Jonathan Fray, Jean-Loic Le Net, Rachel Eccles, Dominique Westbrook, Paul V. Fish, Alan Stobie, Gillian A. Allan, Simon Lempriere Westbrook, Gerwyn Bish, Cécile Sobry
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(12)
New N-(1,2-diphenylethyl)piperazines 6 are disclosed as dual serotonin and noradrenaline reuptake inhibitors (SNRI) which may have potential in treating stress urinary incontinence (SUI). In this Letter, we present new data for SNRI PF-526014 (4) inc
Autor:
Gilles Hanton, John C. Lindon, Jean-Pierre Provost, Jeremy R. Everett, Jean-Loic Le Net, Claude Charuel, Jeremy K. Nicholson, T. Andrew Clayton
Publikováno v:
Archives of toxicology. 81(3)
A (1)H Nuclear Magnetic Resonance (NMR) spectroscopic investigation of the effects of single doses of four model hepatotoxins on male Sprague-Dawley rats showed that hypertyrosinemia was induced by three of the treatments (ethionine 300 mg/kg, galact