Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Jean-Laurent Paparin"'
Autor:
David Dukhan, Thierry Convard, Rachid Rahali, Agnès Amador, Anna Giulia Loi, Valeria Mascia, Massimiliano LaColla, Julien Milhau, Eric Badaroux, Maria Seifer, Loredana Onidi, Ludovic Griffe, Claire Pierra Rouviere, Joe McCarville, Dominique Louis Nestor Ghislain Surleraux, Efisio Sais, Daniel Da Costa, David Standring, Jean-François Griffon, Frédéric Leroy, Michel Liuzzi, Jean-Laurent Paparin, Cyril B. Dousson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:4536-4541
The hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells and, as a consequence, is an attractive target for selective inhibition. This Letter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0889ad7344d0de4eb0df64906929abdc
https://doi.org/10.1016/j.bmcl.2016.01.042
https://doi.org/10.1016/j.bmcl.2016.01.042
Autor:
François-René Alexandre, Eric Badaroux, John P. Bilello, Stéphanie Bot, Tony Bouisset, Guillaume Brandt, Sylvie Cappelle, Christopher Chapron, Dominique Chaves, Thierry Convard, Clément Counor, Daniel Da Costa, David Dukhan, Marion Gay, Gilles Gosselin, Jean-François Griffon, Kusum Gupta, Brenda Hernandez-Santiago, Massimiliano La Colla, Marie-Pierre Lioure, Julien Milhau, Jean-Laurent Paparin, Jérôme Peyronnet, Christophe Parsy, Claire Pierra Rouvière, Houcine Rahali, Rachid Rahali, Aurélien Salanson, Maria Seifer, Ilaria Serra, David Standring, Dominique Surleraux, Cyril B. Dousson
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(18)
Herein we describe the discovery of IDX21437 35b, a novel RPd-aminoacid-based phosphoramidate prodrug of 2'-α-chloro-2'-β-C-methyluridine monophosphate. Its corresponding triphosphate 6 is a potent inhibitor of the HCV NS5B RNA-dependent RNA polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8795b8e1e924d640806c19eaa1d19ab
https://pubmed.ncbi.nlm.nih.gov/28835346
https://pubmed.ncbi.nlm.nih.gov/28835346
Autor:
Jean-Laurent Paparin, Thierry Convard, Catherine Caillet, Stéphanie Bot, Dominique Louis Nestor Ghislain Surleraux, Claire Pierra, Valeria Mascia, Maria Seifer, Jean-François Griffon, Efisio Sais, Agnès Amador, David Dukhan, Cyril B. Dousson, Elodie Rosinosky, Loredana Onidi, Anna Giulia Loi, Rachid Rahali, Eric Badaroux, Massimiliano LaColla, Frédéric Leroy, David Standring, Michel Liuzzi, Joe McCarville, Julien Milhau, Ludovic Griffe, Daniel Da Costa
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(11)
Hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase (RdRp) plays a central role in virus replication. NS5B has no functional equivalent in mammalian cells, and as a consequence is an attractive target for selective inhibition. This paper descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cabbb65889368ef3bd04a5068480e29
https://pubmed.ncbi.nlm.nih.gov/28416131
https://pubmed.ncbi.nlm.nih.gov/28416131
Publikováno v:
European Journal of Organic Chemistry. 2000:3909-3918
The [4+3] cycloaddition reaction between alkyloxycarbonyl-substituted pyrroles and α,α′-dibromo ketones in the presence of diethylzinc has been extended to a wide range of substrates. The functionalization of the resulting tropanes has been studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe5b87760b57b6b0a69b077f28f20302
https://doi.org/10.1002/1099-0690(200012)2000:23<3909::aid-ejoc3909>3.0.co
https://doi.org/10.1002/1099-0690(200012)2000:23<3909::aid-ejoc3909>3.0.co
Publikováno v:
Tetrahedron Letters. 41:2343-2346
The first synthesis of N-Boc-protected tropanes by a [4+3] cycloaddition reaction is described. The Boc group has been cleanly removed demonstrating that this group would be very useful for the synthesis of ‘tropane-like’ scaffolds for combinator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::926ba9c00ab85b3b81b1af275916887c
https://doi.org/10.1016/s0040-4039(00)00198-2
https://doi.org/10.1016/s0040-4039(00)00198-2
Publikováno v:
Journal of Heterocyclic Chemistry. 37:411-418
Tetrahydropyridines 4a, 4b, 4c and pyridines 7a, 7b, 7c, 9a, 9b, 9c were synthesized by a [4 + 2] cycloaddition between 1,4-bis aryl-2-aza-1,3-butadienes and electron-poor dienophiles. Dimeric cycloadducts 6a, 6b, 6c, were also isolated indicating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc700a0604af2b76ed637acb74d2852a
https://doi.org/10.1002/jhet.5570370230
https://doi.org/10.1002/jhet.5570370230
Publikováno v:
ChemInform. 31
The first synthesis of N-Boc-protected tropanes by a [4+3] cycloaddition reaction is described. The Boc group has been cleanly removed demonstrating that this group would be very useful for the synthesis of ‘tropane-like’ scaffolds for combinator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbfdbddb2dead0a290b0e00c8a730223
https://doi.org/10.1002/chin.200027155
https://doi.org/10.1002/chin.200027155
Publikováno v:
ChemInform. 31
Tetrahydropyridines 4a, 4b, 4c and pyridines 7a, 7b, 7c, 9a, 9b, 9c were synthesized by a [4 + 2] cycloaddition between 1,4-bis aryl-2-aza-1,3-butadienes and electron-poor dienophiles. Dimeric cycloadducts 6a, 6b, 6c, were also isolated indicating a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b37fc77a1ed1c702760a29051bd474dc
https://doi.org/10.1002/chin.200038145
https://doi.org/10.1002/chin.200038145